[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypertensive-urgency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypertensive-urgency":101},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,74],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100632259",false,"NCT07511361","Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension","A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Two-Part Study to Evaluate the Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension","KARDINAL-ASH","Key Inclusion Criteria:\n\n* Age 18 or older, body weight ≥ 50 kg with BMI ≤45.0 kg\u002Fm2\n* Ready for discharge or recently discharged from the hospital to home (within the past 7 days) during which evaluation and\u002For treatment of acute severe hypertension (documented SBP ≥ 180 mmHg and\u002For DBP ≥ 110 mmHg) occurred, as measured by a healthcare provider (HCP) within the 24 hours preceding hospitalization or during the initial 24 hours of hospitalization\n* At Screening and Randomization visit, average resting office systolic blood pressure ≥ 145 mmHg\n* Presence of established cardiovascular or renal disease\n\nKey Exclusion Criteria:\n\n* Has known history of secondary hypertension\n* Any malignancy requiring treatment within 5 years (except for basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix that has been successfully treated)\n* Has abnormal thyroid function with clinical significance\n* Recent hospitalization for stroke, myocardial infarction or coronary revascularization within 30 days prior to screening\n* History of and\u002For obvious clinical signs or symptoms of cirrhosis or other significant liver disease\n* Alanine aminotransferase or aspartate aminotransferase \\>2 x upper limit of normal\n* Most recent hospitalization was for non-cardiovascular or non-renal conditions","ALL","18 Years",{"count":19,"type":20},140,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.",[26,27,28,29],"Hypertension","Acute Severe Hypertension","Hypertensive Emergency","Hypertensive Urgency","RECRUITING","2026-06-29",{"date":33,"type":34},"2026-07-01","ACTUAL",{"date":36,"type":34},"2026-06-23",{"date":38,"type":20},"2027-02",{"name":40,"class":41},"Kardigan, Inc.","INDUSTRY",8,{"id":44,"slug":4,"hasResults":10,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":73},"100325992","NCT03524222","Home Hospital for Suddenly Ill Adults","Home Hospital for Suddenly Ill Adults: A Clinical Trial","Inclusion Criteria:\n\n* Resides within either a 5-mile or 20 minute driving radius of emergency department\n* Has capacity to consent to study OR can assent to study and has proxy who can consent\n* \\>= 18 years-old\n* Can identify a potential caregiver who agrees to stay with patient for first 24 hours of admission. Caregiver must be competent to call care team if a problem is evident to her\u002Fhim. After 24 hours, this caregiver should be available for as-needed spot checks on the patient. This criterion may be waived for highly competent patients at the patient and clinician's discretion.\n* Primary or possible diagnosis of cellulitis, heart failure, complicated urinary tract infection, pneumonia, COPD\u002Fasthma, other infection, chronic kidney disease, malignant pain, diabetes and its complications, gout flare, hypertensive urgency, previously diagnosed atrial fibrillation with rapid ventricular response, anticoagulation needs, or a patient who desires only medical management that requires inpatient admission, as determined by the emergency room team.\n\nExclusion Criteria:\n\n* Undomiciled\n* No working heat (October-April), no working air conditioning if forecast \\> 80°F (June-September), or no running water\n* On methadone requiring daily pickup of medication\n* In police custody\n* Resides in facility that provides on-site medical care (e.g., skilled nursing facility)\n* Domestic violence screen positive\n* Acute delirium, as determined by the Confusion Assessment Method\n* Cannot establish peripheral access in emergency department (or access requires ultrasound guidance)\n* Secondary condition: end-stage renal disease, acute myocardial infarction, acute cerebral vascular accident, acute hemorrhage\n* Primary diagnosis requires multiple or routine administrations of intravenous narcotics for pain control\n* Cannot independently ambulate to bedside commode\n* As deemed by on-call medical doctor, patient likely to require any of the following procedures: computed tomography, magnetic resonance imaging, endoscopic procedure, blood transfusion, cardiac stress test, or surgery\n* High risk for clinical deterioration\n* Home hospital census is full (maximum 5 patients at any time)",{"count":50,"type":20},3000,[52],"NA","The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be delivered in the home with equal quality and safety, reduced cost, and improved patient experience.",[55,56,57,58,59,60,29,61,62],"Infection","Heart Failure","COPD","Asthma","Gout Flare","Chronic Kidney Diseases","Atrial Fibrillation Rapid","Anticoagulants; Increased","2026-03-16",{"date":65,"type":34},"2026-03-17",{"date":67,"type":34},"2018-01-18",{"date":69,"type":20},"2031-09",{"name":71,"class":72},"Brigham and Women's Hospital","OTHER",2,{"id":75,"slug":4,"hasResults":10,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":82,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100564932","NCT06635603","HYPERTENSIVE CRISIS AND ATMOSPHERIC PRESSURE RELATIONSHIP","HYPERTENSIVE CRISIS AND ATMOSPHERIC PRESSURE RELATIONSHIP: A PROSPECTIVE STUDY","Inclusion Criteria:\n\n1. Age 18 and above\n2. Hypertensive crisis (systolic ≥180 and\u002For diastolic ≥110 mmHg)\n\nExclusion Criteria:\n\n1. Patients presenting with hypertensive emergency (those with end-organ damage)\n2. Patients who have traveled to another city or district within the last 4 days\n3. Pregnant patients",{"count":81,"type":20},350,"7 Days","OBSERVATIONAL","relationship between the onset times of symptoms and the regions of patients presenting to the emergency department with hypertensive crisis (systolic ≥180 and\u002For diastolic ≥110 mmHg) and the fluctuations in atmospheric pressure",[29,86],"Weather",[88,89,90],"atmospheric pressure","hypertension","hypertensive urgency","2024-10-08",{"date":93,"type":34},"2024-10-10",{"date":95,"type":34},"2024-09-15",{"date":97,"type":20},"2025-09-15",{"name":99,"class":72},"Saglik Bilimleri Universitesi",1,""]