[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immunologic-paralysis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immunologic-paralysis":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100396964",false,"NCT04448951","Immune Homeostasis in Sepsis and Septic Shock","Immune Homeostasis in Patients With Sepsis and Septic Shock: a Single Center Observational Study","IMHOTEP","Inclusion Criteria:\n\n* sepsis\u002Fseptic shock (SEPSIS-3)\n* age ≥18\n* informed consent\n* inclusion within first 24hrs after development\u002Fdiagnosis of septic shock\n\nExclusion Criteria:\n\n* disagreement of the patient or legal representative with the entry into the study\n* patients with primary or secondary immunodeficiency\n* presence of active haematological malignancy or an active non-haematological malignancy",true,"ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","90 Days","OBSERVATIONAL","Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.",[26,27,28,29],"Sepsis","Immunologic Paralysis","Immunologic Suppression","Immune Deficiency",[31,32,33,34,35,36,37],"sepsis","septic shock","immune response","immunoparalysis","transcriptomics","flow-cytometry","immunomodulation","RECRUITING","2024-08-20",{"date":41,"type":42},"2024-08-21","ACTUAL",{"date":44,"type":42},"2020-09-01",{"date":46,"type":21},"2027-12-31",{"name":48,"class":49},"Charles University, Czech Republic","OTHER",""]