[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"implant-breast-reconstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:implant-breast-reconstruction":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100515543",false,"NCT05992870","Neoadjuvant Radiotherapy and Immediate Implant-Based Breast Reconstruction","Inclusion Criteria:\n\nWomen \\>18 years with histopathologically-confirmed breast cancer, who:\n\n* require mastectomy for any reason\n* a known indication for (adjuvant) radiotherapy\n* require implant-based breast reconstruction\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* MDT unable to make recommendation for radiotherapy based on pre-operative histopathological and imaging findings\n* Previous history of breast cancer or another malignancy for which radiotherapy of the breast or axilla\n* Pregnant or lactating\n* inflammatory breast cancer","FEMALE","18 Years","75 Years",{"count":18,"type":19},40,"ESTIMATED","INTERVENTIONAL",[22],"NA","Neoadjuvant radiotherapy(NART) followed by mastectomy and immediate DIEP flap reconstruction is feasible and technically safe. However, reports of NACT followed immediate implant-based breast reconstruction are rare. Some studies have shown that NART followed immediate implant-based breast reconstruction seems feasible and can be safely attempted. It's well known that radiotherapy after implant-based breast reconstruction have negative effects on implant and cosmetic results. So, investigators conducted a polit study to learn about acute post-surgical complications following skin-sparing mastectomy and immediate implant-based breast reconstruction after NART.",[25,26,27],"Breast Cancer","Implant Breast Reconstruction","Neoadjuvant Radiotherapy",[29],"neoadjuvant radiotherapy, implant, breast reconstruction","RECRUITING","2025-03-14",{"date":33,"type":34},"2025-03-17","ACTUAL",{"date":36,"type":34},"2023-07-08",{"date":38,"type":19},"2025-10-31",{"name":40,"class":41},"Hubei Cancer Hospital","OTHER",""]