[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intranasal-dexmedetomidine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intranasal-dexmedetomidine":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100634330",false,"NCT07538284","MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)","Minimizing Delirium With Nasal Dexmedetomidine-Induced Sleep in Older Patients Undergoing Major Abdominal Surgery: : a Randomized, Double-blind, Placebo-controlled Trial","MIDDIES","Inclusion Criteria:\n\n* Aged 65-90 years\n* Scheduled for a major abdominal surgery with estimated surgery time ≥ 2 hours\n\nExclusion Criteria:\n\n* Blind, deafness or the inability to speak mandarin\n* Allergy to dexmedetomidine.\n* Renal and liver failure requiring dialysis or Child-Pugh score \\> 5\n* Follow-up difficulties (i.e. active substance abuse, psychotic disorder, homelessness)\n* Previous major abdominal or cardiac surgery within 1 year of surgical procedure\n* Chronic therapy with benzodiazepines and\u002For antipsychotics. Severe deficit due to structural or anoxic brain damage\n* Body weight \\\u003C 35 kg","ALL","65 Years","90 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","This study aims to determine whether, compared with placebo, the nighttime self-administration of a nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients.",[28,29,30,31],"Major Abdominal Surgery","Postoperative Delirium (POD)","Sleep Disturbances","Intranasal Dexmedetomidine",[33,34],"dexmedetomidine","intranasal administration","NOT_YET_RECRUITING","2026-04-12",{"date":38,"type":39},"2026-04-20","ACTUAL",{"date":41,"type":21},"2026-05-01",{"date":43,"type":21},"2027-06-30",{"name":45,"class":46},"Sixth Affiliated Hospital, Sun Yat-sen University","OTHER",""]