[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"knee-injury-simulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:knee-injury-simulation":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":14,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100592870",false,"NCT06999057","Quadriceps Motor Unit Adaptation to Simulated Knee Injury","Inclusion Criteria:\n\n1. Age 18-30 years\n2. Physically active (Tegner ≥ 5)\n3. No prior lower-limb surgery or major injury\n\nExclusion Criteria:\n\n1. Lower limb surgery or significant injury in past 2 years\n2. Cardiopulmonary, neurological, or psychiatric disorders\n3. Needle\u002Felectrical stimulation anxiety\n4. Medications affecting neuromuscular or psychological function\n5. Pregnancy\n6. Allergic to lidocaine\n7. Inability to elicit Hoffmann reflex",true,"ALL","18 Years","30 Years",{"count":19,"type":20},45,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.",[26,27],"Muscle Inhibition","Knee Injury Simulation",[29,30,31,32,33,34,35,36],"Quadriceps","Electromyography","Motor Unit","Knee Effusion","Lidocaine","Deafferentation","Neuromuscular Adaptation","Muscle Strength","RECRUITING","2026-04-27",{"date":40,"type":41},"2026-05-01","ACTUAL",{"date":43,"type":20},"2026-08-01",{"date":45,"type":20},"2027-08-01",{"name":47,"class":48},"University of Central Florida","OTHER",""]