[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"life-style\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:life-style":433},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,57,91,120,158,181,209,236,264,288,310,364,398],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100409599",false,"NCT04613583","Scottish Advanced Fetal Research Study","Normal Development of the Human Fetus and the Influences and Mechanisms by Which That Development Occurs and is Perturbed","SAFeR","Inclusion Criteria:\n\n* Women at 7-20 weeks of gestation (critical stage of fetal development).\n* Women aged 16 years and older, deemed capable of making a rational decision.\n* Absence of fetal anomaly at ultrasound scan (only normal fetuses are required).\n* Women who are fluent English speakers. This is in order to ensure the woman understands that fetal tissues will be collected.\n\nExclusion Criteria:\n\n* Women exhibiting considerable emotional distress.\n* Fetal anomalies identified at ultrasound scan.",true,"ALL","16 Years",{"count":20,"type":21},1200,"ESTIMATED","OBSERVATIONAL","In-utero exposure to drugs and chemicals through maternal smoking, alcohol use, drug abuse, prescription medicines and occupational\u002Flifestyle exposures is widespread. Such exposures can alter fetal development and programming, leading to the effects becoming \"locked in\" from birth and causing long-term adverse consequences for the individual. These include costly and widespread conditions such as obesity, hypertension, metabolic syndrome and infertility. The weight of evidence linking these conditions to fetal recreational drug or environmental chemical exposures, including cigarettes, alcohol, air pollution, food contact materials, is overwhelming. What is lacking is an understanding of how fetal drug exposure translates to adult ill-health and this is due, largely, to an inability to study the problem directly in affected human fetuses. The investigators, and others, have shown that human fetal development, which lays the foundations of adult health and function (fetal programming), is quite different from the rodent and frequently exhibits surprising aspects. It has become evident that the close interconnectivity of the developing fetal organs and also the placenta, means that a much more holistic approach to research aiming to understand human fetal development and the challenges posed to programming for a health adulthood is critical. To that end the investigators have established a carefully considered gestational age range (7-20 weeks of gestation) of fetuses we can study together with multiple fetal organs and body fluids collected and maternal information recorded.\n\nThe overarching objective of the study is to intensively and systematically study the human fetus during a normal pregnancy and pregnancies where aspects of maternal lifestyle and environment will challenge the fetus. The investigators aim to provide fundamental information to better understand the mechanisms involved and to detect and treat or ameliorate adverse effects during pregnancy (such as maternal smoking\u002Fdrinking, deprivation, exposure to pollution). In the long term findings from this research will be important for future studies aimed at enabling better health in later life.",[25,26,27,28],"Fetal Developmental Abnormality","Fetal Development","Human","Life Style",[30,31,32,33,34,35,36,37,38,39,40,41,42,43],"fetal","human","gestation","development","congenital","exposures","maternal","life style","exogenous chemicals","obesity","deprivation","alcohol","cigarette","endocrine disruption","RECRUITING","2026-05-04",{"date":47,"type":48},"2026-05-05","ACTUAL",{"date":50,"type":48},"2016-05-01",{"date":52,"type":21},"2028-10-01",{"name":54,"class":55},"University of Aberdeen","OTHER",1,{"id":58,"slug":4,"hasResults":10,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":77,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":56},"100540001","NCT06311162","Early Life Intervention in Pediatrics Supported by E-health - SMOKE","Early Life Intervention in Pediatrics Supported by E-health (ELIPSE II): Coaching Parents to Lower Second-hand Smoke Exposure in Children A Single-blind Randomized Controlled Parallel-group Clinical Trial","ELIPSE-II","Inclusion Criteria:\n\n* Age: younger than 6 years\n* Exposed to second-hand smoke at home (at least one parent smoking)\n* German speaking parent\n* All sex and ethnic backgrounds\n* Signed informed consent form from parent\n* Children live\u002Fgrow-up in the same household as the parental participant\n* Referred by a health care professional (e.g. physician, midwife, nurse, other professions)\n\nExclusion Criteria:\n\n* Participation in another study\u002Ftrial targeting similar outcomes\n* Participation in an active smoking cessation programme","5 Years",{"count":66,"type":21},160,"INTERVENTIONAL",[69],"NA","Unrestricted parental smoking habits are lifestyle risk behaviors associated with chronic, systemic inflammation, which promotes the pathogenesis of non-communicable diseases (NCDs). Exposure to secondhand tobacco smoke in early life contributes to the development of specific NCDs in children, i.e. asthma. Early preventive measures to improve lifestyle behavior in parents are therefore of utmost importance. The aim of ELIPSE-II is to assess whether an eHealth application intervention for parents is feasible and efficacious in lowering levels of urinary cotinine as a measure of second-hand smoke exposure in their children .",[72,73,74,75,28,76],"Smoking Reduction","Asthma in Children","Wheezing","Non-Communicable Disease","Behavior, Smoking",[78,79,80,81],"Secondhand smoke","Children","Prevention","eHealth","2026-04-30",{"date":84,"type":48},"2026-05-06",{"date":86,"type":48},"2024-05-07",{"date":88,"type":21},"2028-12-31",{"name":90,"class":55},"Insel Gruppe AG, University Hospital Bern",{"id":92,"slug":4,"hasResults":10,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":10,"sex":17,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":67,"phases":102,"briefSummary":103,"conditions":104,"keywords":111,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":119,"locationsCount":56},"100532095","NCT06208345","Early Life Intervention in Pediatrics Supported by E-health","Early Life Intervention in Pediatrics Supported by E-health (ELIPSE I): Coaching Parents to Lower Obesity in Children. A Single-blind Randomized Controlled Parallel-group Clinical Trial.","ELIPSE-I","Inclusion Criteria:\n\n* German speaking parents\n* Any ethnic background\u002Frace\n* Children should live\u002Fgrow-up in the same household as the parental participant\n* Children with an age- and sex-matched BMI \\>97 centile according to Swiss national growth charts\n* Children who attend the outpatient weight management clinic at the Division of Pediatric Endocrinology at the University Children's Hospital Bern\n* Signed informed consent form from parent(s)\n\nExclusion Criteria:\n\n* Syndromic obesity\n* Known congenital disease affecting musculo-skeletal, cardiac or pulmonary function\n* Participation in another clinical trial targeting similar objectives","6 Years","12 Years",{"count":101,"type":21},148,[69],"Childhood obesity in early life contributes to the development of specific NCDs, i.e. adult obesity. Unhealthy diet and low level of physical activity are lifestyle risk behaviors associated with chronic, systemic inflammation, which promotes the pathogenesis of NCDs. Early preventive measures to improve lifestyle behavior are of utmost importance. The aim of ELIPSE-I is to assess whether an eHealth application intervention for parents is feasible and efficacious in lowering total energy intake\u002Ftotal energy expenditure (TEI\u002FTEE) ratio in their children with BMI \\>97 centile (ELIPSE-I).",[105,106,107,108,28,109,110],"Adiposity","Childhood Obesity","Adolescent Obesity","Non-communicable Disease","Behavior, Eating","Behavior, Health",[105,79,112,80,81],"Adolescents","2026-02-12",{"date":115,"type":48},"2026-02-18",{"date":117,"type":48},"2024-02-16",{"date":88,"type":21},{"name":90,"class":55},{"id":121,"slug":4,"hasResults":10,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":16,"sex":17,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":67,"phases":131,"briefSummary":132,"conditions":133,"keywords":137,"overallStatus":148,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":56},"100591501","NCT06981247","Cardiovascular Disease Prevention Strategies for High-risk Urban Sedentary Employees in Karachi, Pakistan","m-Lifestyle Intervention for Employees (m-LIfE): Protocol for a Pilot Cluster Randomized Controlled Trial on Cardiovascular Disease Prevention Strategies","m-LIfE","Inclusion Criteria:\n\n• At least 6 months of job experience in any bank\n\nExclusion Criteria:\n\n* Diagnosed case of myocardial infarction, stroke, coronary heart disease, cerebrovascular disease, or peripheral arterial diseases\n* Pregnant women\n* Individuals with acute illnesses that limit physical activity","20 Years","65 Years",{"count":130,"type":21},84,[69],"Heart diseases and other non-communicable diseases are serious health issues in countries like Pakistan. Many people who work in offices, like bank employees, sit for more than 8 hours a day. This is called a sedentary lifestyle, and it increases the risk of heart diseases.\n\nThis research project aims to find out if a newly developed context specific mobile phone application can help these sedentary employees to improve their lifestyle. The app, called m-LIfE (mHealth-based Lifestyle Intervention for Employees), will be designed to help employees to move more during the day and eat healthier food like fruits and vegetables.\n\nThe study will involve bank employees in urban Karachi, Pakistan. They will be divided into two arms:\n\nIntervention arm: Participants in this arm will use the m-LIfE app for 12 weeks. They will get reminders and tips to take breaks, exercise, and eat healthy.\n\nRoutine care arm: Participants in this arm will receive printed basic educational material about prevention of risk factors of heart diseases and improving lifestyle.\n\nAfter the 12 weeks of intervention, there will be a follow-up period at 4th week to check if participants are maintaining healthy habits.\n\nThis study could help find simple and affordable ways to improve the health of office workers and reduce pressure on the healthcare system.",[134,28,135,136],"Physical Activity","Dietary Habits","Cardiovascular Diseases",[138,139,140,141,142,143,144,145,146,147],"Primary care","Cardiology","Preventive medicine","risk perception","cardiovascular health","CVD","Sedentary lifestyle","mHealth","Digital health","Feasibility","NOT_YET_RECRUITING","2025-12-14",{"date":151,"type":48},"2025-12-17",{"date":153,"type":21},"2026-01",{"date":155,"type":21},"2026-08",{"name":157,"class":55},"Aga Khan University",{"id":159,"slug":4,"hasResults":10,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":10,"sex":17,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":148,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":56},"100574278","NCT06757205","Analysis of the Personality Characteristics and Lifestyle of Young People Who Access Psychiatric Outpatient Clinics","Analysis of the Personality Characteristics and Lifestyle of Young People Who Access Psychiatric Outpatient Clinics: a Qualitative Study","APGP","Inclusion criteria:\n\n\\- Participants will be selected based on their age between 13 and 21, their availability to sign the informed consent.\n\nExclusion criteria:\n\n* Patients who do not give their consent are excluded from the study.\n* Patients who do not speak fluent Italian or those who due to cognitive and\u002For thinking characteristics would not be able to understand or complete the questionnaire are also excluded.","13 Years","21 Years",{"count":168,"type":21},115,"Considering the growing importance of services psychiatric and psychological for adolescence and adulthood incidence of discomfort expressed in this age group, comes assessed the need to provide adequate and targeted services.\n\nReasons:\n\nThe study aims to evaluate the characteristics and trends of adolescents who access the service, in order to frame the type of discomfort expressed and the expectations with respect to access to the service and the resource base on which it can the therapeutic intervention must be thought out and organised. Furthermore, the study aims to identify the factors that influence the request for help and evaluate the quality of the assistance received, with the aim of improving it effectiveness.",[171,28],"Personality","2025-08-11",{"date":174,"type":48},"2025-08-12",{"date":176,"type":21},"2025-09-15",{"date":178,"type":21},"2027-01-15",{"name":180,"class":55},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":182,"slug":4,"hasResults":10,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":16,"sex":17,"minAge":187,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":67,"phases":191,"briefSummary":192,"conditions":193,"keywords":194,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":56},"100503688","NCT05838508","Effect of Physical Activity Pattern on Cardiometabolic Health","PACE","Inclusion Criteria:\n\n* 18-45 yr old\n* Body mass index (BMI) 18.5 - 34.9 kg\u002Fm2\n* No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)\n* Willing to adhere to the protocol requirements for the duration of the study\n\nExclusion Criteria:\n\n* Currently smoking\u002Fvaping or 5 or more years of smoking\u002Fvaping\n* Currently pregnant or breastfeeding\n* History of drug or alcohol dependency\n* History of psychiatric illness or disorder\n* Any hospitalization due to COVID-19\n* Inability to exercise for any reason\n* Any known contraindication to exercise testing based on current ACSM guidelines","18 Years","45 Years",{"count":190,"type":21},26,[69],"The goal of this study is to understand the interaction between the circadian system and physical activity.\n\nParticipants will:\n\n* complete 2 inpatient stays\n* perform moderate exercise\n* be provided with identical meals\n* have frequent blood draws\n* provide urine and saliva samples",[28],[195,196,197,198,199],"exercise","circadian system","physical activity","glucose tolerance","blood pressure","2025-06-11",{"date":202,"type":48},"2025-06-13",{"date":204,"type":48},"2024-10-11",{"date":206,"type":21},"2026-08-30",{"name":208,"class":55},"Brigham and Women's Hospital",{"id":210,"slug":4,"hasResults":10,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":16,"sex":17,"minAge":187,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":67,"phases":217,"briefSummary":218,"conditions":219,"keywords":224,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":56},"100569172","NCT06690788","PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes","PT2T","Inclusion Criteria:\n\n1. \"Target partner\" is eligible for the National DPP per CDC eligibility requirements:\n\n   * BMI ≥ 25 kg\u002Fm² (≥ 23 kg\u002Fm² if Asian American), and\n   * Do not have a diagnosis of type 1 or type 2 diabetes, and\n   * Not currently pregnant, and\n   * High risk for type 2 diabetes based on: (i) CDC Prediabetes Risk Test score ≥ 5, (ii) clinically diagnosed Gestational Diabetes during a previous pregnancy (for women), or (iii) a blood test result indicative of prediabetes in the past year (i.e., fasting blood glucose 100-125 mg\u002Fdl; plasma glucose 140-199 mg\u002Fdl measured 2 hours after a 75 g glucose load; or HbA1c 5.7%-6.4%).\n2. The couple has lived together for 1+ years.\n3. Both partners are willing to participate in the research.\n4. Both partners are at least 18 years old.\n5. Both partners are fluent in English.\n\nEXCLUSION CRITERIA:\n\n1. \"Supporting partner\" has a diagnosis of Type 2 Diabetes.\n2. Either partner:\n\n   * Has a diagnosis of another chronic disease (unless no major events\u002Fchanges for 3+ months), or\n   * Is currently on medication or engaged in lifestyle intervention for prediabetes or obesity, or\n   * Has previously participated in the National DPP, or\n   * Reports discomfort participating in a lifestyle program with their partner, or\n   * Reports a low level of relationship commitment (i.e., \"4\" or lower on a scale from 1 (do not agree at all) to 7 (agree completely) on the item \"I want this relationship to stay strong no matter what rough times we encounter.\"; Owen et al., 2011).",{"count":216,"type":21},324,[69],"Nearly half of adults in the United States have or are at risk of developing type 2 diabetes. The overall goal of this community-engaged research is to examine the efficacy of an innovative couple-based lifestyle intervention to prevent type 2 diabetes that is applicable to a broad range of partnered adults in the United States. By simultaneously targeting lifestyle and perceived support from romantic partners, there is a high likelihood of creating lasting changes in both",[220,28,221,222,134,223],"Prediabetic State","Intervention Study","Social Support","Obesity",[225,80,222,226],"Lifestyle Intervention","Couple Relationships","2025-05-28",{"date":229,"type":48},"2025-05-30",{"date":231,"type":48},"2025-03-06",{"date":233,"type":21},"2028-11",{"name":235,"class":55},"University of Utah",{"id":237,"slug":4,"hasResults":10,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":16,"sex":17,"minAge":187,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":67,"phases":245,"briefSummary":246,"conditions":247,"keywords":252,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":263},"100381090","NCT04242069","Healthy for my Baby- RCT of a Lifestyle Intervention for Overweight Women in Preconception","Healthy for my Baby- A Randomized Controlled Trial Assessing a Preconception Clinically Integrated Technological Intervention to Improve the Lifestyle of Overweight Women and Their Partners","Inclusion Criteria:\n\n* Women and their partner who wish to conceive within 12 months of trial inclusion\n* Woman's body mass index ≥ 25 kg\u002Fm2\n* Access to a smart phone\n\nExclusion Criteria:\n\n* Insufficient knowledge of French or English\n* Anticipated move to another region\n* Personal history of infertility\n* Type 1 or 2 diabetes mellitus\n* Prior bariatric surgery\n* Active eating disorder established by clinical diagnosis\n* Medical contraindication to pregnancy\n* Medical contraindication to physical activity\n* Participation in another intensive lifestyle intervention\n* Known or anticipated disease or surgery likely to cause an important weight loss\n* Multiple pregnancies will be excluded from the pregnancy follow-up to limit aberrant data","40 Years",{"count":244,"type":21},68,[69],"The purpose of this study is to determine whether an intervention combining motivational interviewing and follow-up with a mobile phone application will help overweight women and their partners adopt healthy lifestyle habits in the preconception period. This study will also evaluate the impact of the intervention on the weight, waist circumference, and body fat of women and their partners. Women and their partners will be followed through pregnancy to explore the effects of the intervention on the adequacy of gestational weight gain, rates of pregnancy complications, delivery mode, and infant birth weight.",[248,249,250,28,251],"Overweight and Obesity","Pregnancy Complications","Health Behavior","Preconception Care",[253],"Metabolomics","2025-03-28",{"date":256,"type":48},"2025-04-02",{"date":258,"type":48},"2021-06-18",{"date":260,"type":21},"2026-07-30",{"name":262,"class":55},"Université de Sherbrooke",2,{"id":265,"slug":4,"hasResults":10,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":269,"eligibilityCriteria":270,"healthyVolunteers":10,"sex":271,"minAge":187,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":67,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":56},"100579201","NCT06821217","The Effect of an App-based Intervention on Quality of Life in Patients With Endometriosis.","A Mobile Application as Supportive Treatment of Endometriosis: the Effect on Quality of Life and Endometriosis-associated Pain. A Randomized Controlled Trial.","MASQUE","Inclusion Criteria:\n\n* Informed Consent as documented by signature\n* Age 18 or older\n* Premenopausal status (menopause is defined as amenorrhea lasting one year or longer)\n* Endometriosis, confirmed by surgery or clinically suspected\n* Possession of a smartphone\n\nExclusion Criteria:\n\n* Planned endometriosis surgery or planned hormonal therapy in the study period\n* Surgery and\u002For new hormonal therapy in the last three months\n* Malignant diseases\n* Pregnancy\n* Breastfeeding\n* Active desire for pregnancy in the study period\n* Fertility treatment\n* Simultaneous participation in other intervention studies","FEMALE",{"count":273,"type":21},308,[69],"The goal of this clinical trial is to learn if an App-based intervention affects the quality of life in patients with suspected or confirmed endometriosis. The main questions it aims to answer are:\n\n* Does the App-based intervention improve the quality of life?\n* Does it lead to pain relief? Researchers will compare participants using the App to a control group to see if the App works to improve quality of life and endometriosis-related symptoms.\n\nParticipants will:\n\n* Use an App-based intervention or be in the control group (no App-use) for 6 months\n* Visit or have a telephone consultation after 3 and 6 months\n* Complete a questionnaire to assess the quality of life at inclusion, after 1, 3 and 6 months",[277,278,279,28],"Endometriosis","Pain","Quality of Life","2025-02-11",{"date":282,"type":48},"2025-02-14",{"date":284,"type":48},"2024-03-01",{"date":286,"type":21},"2027-08-31",{"name":90,"class":55},{"id":289,"slug":4,"hasResults":10,"nctId":290,"briefTitle":291,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":10,"sex":17,"minAge":187,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":67,"phases":296,"briefSummary":297,"conditions":298,"keywords":299,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":309},"100349251","NCT03827382","Bicycle Exercise and Lifestyle Intervention in Newly Diagnosed Diabetes","BELIFE","Inclusion Criteria:\n\n* Informed consent as documented by signature\n* Type 2 diabetes diagnosed within the last two years according to the American Diabetes Association (ADA) criteria\n* Age ≥ 18 years\n* HbA1c ≥ 7.5 %\n\nExclusion Criteria:\n\n* Clinically instable patient as defined by the physicians on duty including signs of new cardiac ischemia in the ECG, systolic blood pressure ≥ 200 mmHg, fever ≥ 38.5 °C, symptoms of SIRS or reduced vigilance.\n* Anti-diabetic medication for ≥ 24 hours\n* Inability to perform a bicycle exercise during 30 minutes\n* Previous lifestyle-intervention by an endocrinologist\n* Engagement in physical activity more than five times per week\n* Enrollment in other interventional study",{"count":295,"type":21},62,[69],"The aim of the study is to test the efficacy, feasibility, and safety of a bicycle exercise followed by an intensive lifestyle intervention for 3 months in patients with recent onset and medically untreated type 2 diabetes.",[28],[300,301],"Life Style Intervention","Type 2 Diabetes mellitus",{"date":282,"type":48},{"date":304,"type":48},"2019-02-01",{"date":306,"type":21},"2025-12-31",{"name":308,"class":55},"University Hospital, Basel, Switzerland",3,{"id":311,"slug":4,"hasResults":10,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":16,"sex":17,"minAge":187,"maxAge":4,"enrollmentInfo":317,"targetDuration":4,"studyType":67,"phases":319,"briefSummary":320,"conditions":321,"keywords":330,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":56},"100417487","NCT04716322","Health-Enhancing Adapted Physical Activity Program at \"Mon Stade\"","Study of the Determinants Associated With Sustained Changes in Physical Activity Behaviors, and Their Effects on the Prevention and Treatment of Chronic Diseases, in Individuals Enrolled in an Adapted Physical Activity Program","SESAME","Inclusion Criteria:\n\n* Male or female\n* 18 years of age or older\n* Speaking and understanding French\n* Affected by a chronic pathology according to a predefined list (LTI, obesity, HTA, COPD, COVID-19 with persistent symptoms)\n* Carrier of a writing APA prescription\n* Able to come to \"Mon Stade\" twice a week for their APA sessions following the 16-week health-adapted PA program;\n* Signature of the information and consent form.\n\nExclusion Criteria:\n\n\\- Women whose pregnancy is known",{"count":318,"type":21},2024,[69],"Introduction: Regular practice of exercise or physical activity (PA) is a recognized intervention as a determinant of good health acquisition, maintenance, or recovery for a large number of chronic pathologies. Nevertheless, few studies have evaluated adherence to an initial health-adapted PA (APA) program, and persistence of active behavior over the time in individuals with a chronic disease.\n\nThe aim of the study is to determine the brakes and levers associated with motivation and long-term compliance. In addition, the investigators aim to evaluate the cost-effectiveness of such program in term of care consumption. Finally, the investigators complete their interest for APA prescription from practitioners agreeing to enroll their patients in the present study.\n\nMethod: The investigators perform a prospective monocentric cohort, of 2024 patients affected of a chronic disease or long-term illness (LTI), enrolled from 2021 to 2024 (4 years, 506 per year), for a 16-week APA program, and followed 5 years with an annual fitness and habits of life and care consumption evaluation.",[322,323,324,325,28,326,327,328,134,329],"Exercise Therapy","Behavior and Behavior Mechanisms","Adherence, Patient","Lifestyle, Sedentary","Life Style, Healthy","Cost-Benefit Analysis","Prescriptions","Adapted Physical Activity",[329,331,332,333,334,335,336,337,338,339,340,341,342,343,344,345,346,347,348,134,349,350,80,351,352,353,354],"Active Live Habits","Adherence","Aerobic Capacity","Behavior","Body Composition","Budget Impact Analysis","Cardiorespiratory Fitness","Care Consumption","Chronic Disease","DEXA scan","Exercise","Health-Adapted Physical Activity","Health-Enhancing","Life-Style","Long-Term Illness","Medico-Economic","Motivation","Perceived Barriers","Physical Fitness","Prescription","Psycho-social","Quality Of Life","Questionnaire","VO 2 measurement","2022-04-06",{"date":357,"type":48},"2022-04-07",{"date":359,"type":48},"2021-01-28",{"date":361,"type":21},"2030-12-31",{"name":363,"class":55},"Mon Stade Sports Medicine Centre",{"id":365,"slug":4,"hasResults":10,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":369,"eligibilityCriteria":370,"healthyVolunteers":16,"sex":17,"minAge":371,"maxAge":372,"enrollmentInfo":373,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":375,"conditions":376,"keywords":378,"overallStatus":148,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":396,"locationsCount":4},"100436241","NCT04960670","LIMIT Early Adiposity Rebound in Children","LIMIT (LIfestyle and Microbiome InTeraction) Early Adiposity Rebound in Children","LIMIT","* Inclusion criteria: i) Infants of both sexes born to vaginal\u002Fcaesarean delivery; ii) Gestational age: 37-42 weeks; iii) Italian-speaking parent; iv) 7 Ability of the parent\u002Fguardian to give informed consent; v) Ability of the mother to answer questionnaires.\n* Exclusion Criteria: i) Infants with genetic\u002Fcongenital diseases; ii) Infants selected for another clinical study; iii) Infants hospitalized immediately after birth; iv) Presence of gestational diabetes; v) Presence of hyperthyroidism during pregnancy; vi) Parents refusing to sign the informed consent.","1 Day","48 Months",{"count":374,"type":21},150,"Childhood obesity is a strong predictor of adult obesity with health and economic consequences for the individual and society. Adiposity rebound (AR) is a rise in the Body Mass Index occurring between 3-7 years. Early adiposity rebound (EAR) occurs at a median age of 2 years and is a risk factor for later obesity. Events happening in \"the first 1,000 days\" play a role in obesity development. One of the key elements in this crucial time window is the gut microbiome, a highly dynamic organ that is sensitive to environmental exposure being linked to obesity development. Prenatal (dietary\u002Flifestyle maternal factors and environmental exposure) and postnatal determinants (the type of feeding, sleep patterns, speed of growth) and environmental obesogenic pollutants may influence the infant microbial colonization, thus increasing the risk of EAR onset.\n\nLIMIT will holistically identify the longitudinal interplay between the intestinal microbiome and infant\u002Fmaternal nutritional and lifestyle habits, environmental factors exposure and anthropometric measurements, in children with AR vs EAR, driving new mechanistic insights to create an EAR predictive model.\n\nThe study will evaluate a group of 150 mother-infant pairs, during the first four years of life at different follow-up.",[106,28,377],"Intestinal Microbiome",[379,380,381,382,383,384,385,386,387,388],"childhood obesity","maternal lifestyle","gut microbiome","adiposity rebound","fetal programming","first thousand days","pregnancy","breastfeeding","children nutrition","endocrine disruptors chemicals","2021-07-01",{"date":391,"type":48},"2021-07-14",{"date":393,"type":21},"2021-12-01",{"date":395,"type":21},"2026-12-31",{"name":397,"class":55},"University of Pavia",{"id":399,"slug":4,"hasResults":10,"nctId":400,"briefTitle":401,"officialTitle":401,"acronym":402,"eligibilityCriteria":403,"healthyVolunteers":16,"sex":17,"minAge":187,"maxAge":404,"enrollmentInfo":405,"targetDuration":4,"studyType":67,"phases":407,"briefSummary":408,"conditions":409,"keywords":413,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":56},"100297781","NCT03156478","STOP DIABETES - Knowledge-based Solutions","StopDia","Inclusion Criteria:\n\n* age of 18-70 years\n* 12 points or more in the Finnish diabetes risk score or previous gestational diabetes or repeated impaired fasting glucose (IFG) (fasting plasma glucose level 6,1 - 6,9 mmol\u002Fl) or impaired glucose tolerance (2-hour glucose level 7,8 - 11,0 mmol\u002Fl in oral glucose tolerance test)\n* living in the hospital district of Northern Savo, Päijät-Häme or South Karelia\n* possibility to use computer, smartphone or tablet with internet connection\n* having own self-phone number\n* adequate Finnish language skill\n\nExclusion Criteria:\n\n* type 1 or 2 diabetes\n* pregnancy or breastfeeding\n* current cancer or less than 6 months from the end of cancer treatment","70 Years",{"count":406,"type":21},10000,[69],"The aim of the Stop Diabetes - Knowledge based solutions (StopDia) consortium project (University of Eastern Finland, National Institute for Health and Welfare, and Technical Research Centre of Finland) is to develop and test approaches to identify individuals at increased risk of type 2 diabetes and to empower them in adopting and maintaining a healthy lifestyle by combining individual and environment level strategies into a dual-process approach targeting deliberative and automatic processes of behavior. We also aim to identify barriers and facilitators of adopting a healthy lifestyle in the society, create a model for the prevention of type 2 diabetes by joint actions of health care, third sector, and other societal actors, and develop methods to monitor the cost-effectiveness of these actions. We will carry out a 1-year randomized controlled trial on the effects of among 10 000 individuals aged 18-70 years at increased risk of type 2 diabetes living in Finland. The participants will be randomized into the control group, the digital lifestyle intervention group, or the combined digital and face-to-face lifestyle intervention group. The aim of the interventions is to enhance diet quality, increase physical activity, decrease body weight, and improve glucose tolerance in individuals at increased risk of type 2 diabetes.",[410,28,411,134,412],"Type2 Diabetes","Diet Habit","Empowerment",[80,414,415,416,417,418,419,420,421,422,423],"Digital solutions","Type 2 diabetes","Life style modification","Physical activity","Healthy diet","Health economics","Environmental choice architecture","Socio-economic facilitators","Socio-economic barriers","Wellbeing","2017-05-15",{"date":426,"type":48},"2017-05-17",{"date":428,"type":48},"2017-04-10",{"date":430,"type":21},"2037-12",{"name":432,"class":55},"University of Eastern Finland",""]