Lumbar Spondylosis

9

Review clinical trials related to Lumbar Spondylosis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

Participants needed: 80
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Yale UniversityUpdated: Jun 10, 2026
Eligibility criteria

Diagnosis of chronic pain (generally pain duration of at least 3-6 months) local... [+3]

Cryoneurolysis performed as part of a separate investigational trial in which da... [+3]

Status: Recruiting

RFA Using Multi-Tined Electrodes vs.Traditional Electrodes for Lumbar Spondylosis

Spondylosis is an anatomical defect of the small facet joints between the spinal vertebrae often due to load bearing and mechanical wear. It is a major contributor to lower back pain. The current standard of care in patients diagnosed with spondylosis in the lower back is to perform a radiofrequency ablation (RFA) of the lumbar medial branch nerves which carry the pain signals from that region to the brain. RFA accomplishes this by using radio waves transmitted through inserted electrodes. This leads to a temporary lesion or "burn"; stopping the pain signals from being transmitted as as well as changing the pain signals themselves. The electrodes themselves do not heat up but instead cause ions in the surrounding tissue to vibrate and heat up. When performing the procedure at the UAMS pain clinic, one can use the Stryker system with a single electrode end which protrudes out of the cannula or the Stratus Nimbus electrode with two prongs which expand in a "V"; formation along the sides of the cannula. While testing in chicken tissue shows that the latter electrode type produces a larger lesion size, anecdotal evidence suggests that it may lead to longer term pain relief. As such, the choice is currently left up to physician preference as both are FDA approved for use in this condition. This study is trying to assess if the larger lesion size results in a reduction in impairment of activities of daily living due to pain measured by the patient-reported PROMIS (Patient Reported Measurement Information System)-29 questionnaire. The PROMIS-29 is given to all patients who are seen in the UAMS Pain Clinic at initial and follow-up visits. In this study we would like to randomize what electrode and cannula set is used in RFA for patient's who are already going to be receiving the procedure for treatment for their spondylosis. The study team would then compare the PROMIS outcomes between cases that used the Stryker and Stratus Nimbus electrodes at 1,3,6,9 and 12 months. It is hypothesized that the Nimbus electrode will result in a greater reduction and improvement in PROMIS scores for a longer duration than the Stryker electrode.

Participants needed: 25
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of ArkansasUpdated: Jun 8, 2026Locations: 1
Eligibility criteria

Greater than 18 years of age [+3]

History of known coagulopathy [+7]

Status: Recruiting

Catgut Embedding for Lumbar Spondylosis With Blood Stasis Syndrome

The goal of this clinical trial is to learn if catgut embedding works to treat chronic low back pain in adults with lumbar spondylosis and "Blood Stasis" syndrome. The main questions it aims to answer are: Does catgut embedding lower back pain more effectively than electro-acupuncture? Does catgut embedding improve the daily physical activities of participants? Researchers will compare catgut embedding to electro-acupuncture to see which method works better to reduce pain and improve quality of life. All participants will also receive counseling on lifestyle changes and back exercises. Participants will: Be randomly assigned to receive either catgut embedding (2 sessions over 4 weeks) or electro-acupuncture (20 sessions over 4 weeks). Visit the clinic for treatments and checkups. Complete surveys about their pain levels and ability to perform daily tasks at the start, at 2 weeks, and at 4 weeks.

Participants needed: 66
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: University of Medicine and Pharmacy at Ho Chi Minh CityUpdated: May 15, 2026Locations: 1
Eligibility criteria

Age and Gender: Patients aged 18 to 65 years, regardless of gender. [+8]

Neurological Deficits: Patients with clinical neurological abnormalities in the... [+3]

Status: Not yet recruiting

Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves

The purpose of this voluntary research study is to determine whether the parasagittal approach to lumbar medial branch (LMB) nerve radio frequency ablation (RFA) will have greater efficacy than the traditional approach to lumbar medial branch nerve radio frequency ablation.

Participants needed: 25
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Milton S. Hershey Medical CenterUpdated: May 12, 2026Locations: 1
Eligibility criteria

Bilateral equally intense axial low back pain [+5]

Radicular pain below the knee [+11]

Status: Recruiting

The NOTICE Study: Neurosurgery and OrThopedIcs Communication Evaluation Study Following Lumbar Fusions

The purpose of this single-blind, randomized, controlled study is to assess the efficacy of "informative text messages" vs "traditional handouts" provided to lumbar spine surgery patients post-operatively.

Participants needed: 224
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Duke UniversityUpdated: May 8, 2026Locations: 1
Eligibility criteria

Primary lumbar fusion 1-4 levels [+6]

Prior lumbar fusions [+5]

Status: Not yet recruiting

Efficacy of Electroacupuncture Combined With Auricular Acupressure for Chronic Low Back Pain.

Chronic low back pain (CLBP) due to lumbar spondylosis is a leading cause of disability, significantly impacting the quality of life in middle-aged and elderly populations. While electroacupuncture (EA) and auricular acupressure (AA) are recognized as safe, non-pharmacological therapies, high-quality clinical evidence specifically evaluating their combined effects on CLBP patients with TCM "Kidney Yin deficiency" syndrome remains limited.This randomized controlled trial aims to evaluate the efficacy and safety of combining EA with AA (utilizing Vaccaria segetalis seeds) compared to EA combined with sham AA. The study will focus on 76 eligible patients at Le Van Thinh Hospital. Primary objectives are to measure changes in pain intensity (VAS) and functional improvement (ODI) at three intervals: baseline (T0), after 7 days (T1), and upon completion of the 14-day intervention (T2). The findings are expected to provide an evidence-based foundation for an integrated treatment approach to manage chronic lumbar pain effectively.

Participants needed: 76
Trial details
Age: 40-70Biological sex: AllType: InterventionalSponsor: University of Medicine and Pharmacy at Ho Chi Minh CityUpdated: Apr 15, 2026Locations: 1
Eligibility criteria

Age between 40 and 70 years. [+6]

Contraindications to auricular acupressure (e.g., ear skin infection) or electro... [+4]

Status: Recruiting

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.

Participants needed: 125
Trial details
Phase: Phase 4Age: 18-80Biological sex: AllType: InterventionalSponsor: John O'TooleUpdated: Feb 17, 2026Locations: 1
Eligibility criteria

Age 18-80 [+2]

Opioid tolerant at the time of the surgical procedure--defined as consuming grea... [+7]

Status: Not yet recruiting

Correlation Between Radiculopathy And Quality Of Life In Patients With Chronic Lumbar Spondylosis

This study will be conducted to answer the following question: Is there a Correlation Between Lumbar Radiculopathy and Quality of Life in Patients with chronic lumbar spondylosis?

Participants needed: 132
Trial details
Age: 30-50Biological sex: AllType: ObservationalSponsor: Cairo UniversityUpdated: Dec 6, 2024
Eligibility criteria

All patient diagnosed and referred from a physician [+4]

Pregnant and breast-feeding women [+3]

Status: Recruiting

To Brace or Not to Brace for Single Level Lumbar Fusion Pilot

The use of a lumbar brace following single-level lumbar fusion for degenerative spondylosis (non-traumatic) is variable between surgeons. Some surgeons prefer to prescribe a brace and others do not. There is a lack of guidelines and evidence to support either treatment option. The purpose of this study is to assess feasibility and collect preliminary data to conduct a larger, definitive trial to provide evidence as to whether prescribing a brace or not results in better or equal outcomes. Imaging by CT scan, one year after surgery, will be used to analyze bone fusion (healing), and functional and pain scores from patients during their recovery will be compared to identify differences between patients who wore a brace and those who did not.

Participants needed: 50
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Hamilton Health Sciences CorporationUpdated: Oct 23, 2024Locations: 1
Eligibility criteria

Single-level lumbar instrumented postero-lateral fusion from L2-L5 [+1]

Previous lumbar surgery [+3]