[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"masked-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:masked-hypertension":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100270750",false,"NCT02804074","MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement","MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement (MASTER Study)","MASTER","Inclusion Criteria:\n\n* Male and female subjects\n* Age 35-80 years\n* Masked uncontrolled (in treatment) hypertension: office BP \\\u003C140\u002F90 mmHg, and one or more of the following situations:\n\n  * Ambulatory daytime BP \\>135\u002F85 mmHg\n  * Ambulatory night-time ABP \\> 120\u002F70 mmHg\n  * Ambulatory 24h ABP \\>130\u002F80 mmHg\n* eGFR ≥45 mL\u002Fmin\u002F1.73 m2 (CKD-EPI creatinine equation 2009)\n\nExclusion Criteria:\n\n* eGFR \\\u003C45 mL\u002Fmin\u002F1.73 m2 (CKD-EPI creatinine equation 2009), and in particular severe chronic renal failure defined as serum creatinine \\> 250 umol\u002Fl;\n* Patients in unstable clinical conditions;\n* Known secondary hypertension;\n* Orthostatic hypotension (SBP fall \\> 20 mmHg on standing);\n* Dementia (clinical diagnosis);\n* Hepatic disease as determined by either AST or ALT values \\> 2 times the upper limit of normal\n* History of gastrointestinal surgery or disorders which could interfere with drug absorption\n* Known allergy or contraindications to one of the drugs to be administered in the study\n* History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years\n* History of clinically significant autoimmune disorders such as systemic lupus erythematosus.\n* History of drug or alcohol abuse within the last 5 years\n* History of non-compliance to medical regimens and\u002For patients who are considered potentially unreliable\n* Inability or unwillingness to give free informed consent\n* Pregnancy or planned pregnancy during study period.","ALL","35 Years","80 Years",{"count":20,"type":21},1240,"ESTIMATED","INTERVENTIONAL",[24],"NA","MASTER study is a 4-year prospective, randomized, open-label, blinded-endpoint study (PROBE) comparing 2 management strategies 1) office BP as a guide to treatment, or 2) 24-hour ABP as a guide to treatment. Study objectives are to investigate whether a management strategy based on out-of-office BP (Ambulatory BP monitoring) versus a management strategy based on office BP measurements is associated with differences in outcome, including cardiovascular and renal intermediate end points at one year; cardiovascular events at 4 years and changes in a number of blood pressure-related variables throughout the study. Patients will be followed-up during the first year focusing on changes in left ventricular mass index (LVMI, co-primary endpoint) and Urinary albumin excretion (UAE, albumin\u002Fcreatinine ratio, co-primary end-point), and during the whole 48 month period for both changes in LVMI and UAE and events including all-cause mortality, CV morbidity and mortality, cerebral morbidity and mortality.A total of 1240 subjects will be recruited by 30 centers, taking into account a dropout rate of 15% (620 subjects per randomization arm).",[27],"Masked Hypertension","RECRUITING","2026-03-25",{"date":31,"type":32},"2026-03-30","ACTUAL",{"date":34,"type":32},"2018-10-01",{"date":36,"type":21},"2026-12",{"name":38,"class":39},"Istituto Auxologico Italiano","OTHER",2,""]