[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"metabolic-inflexibility\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:metabolic-inflexibility":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":24,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100387094",false,"NCT04320264","Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis","Inclusion Criteria:\n\n* 18-50 years old\n* BMI of 25 - 30 kg\u002Fm2\n* BMI \\> 40kg\u002Fm2\n* Lactate levels in top and lower 25%\n\nExclusion Criteria:\n\n* Pregnant women\n* Mentally disabled\n* Prisoners\n* Smokers\n* Subjects with heart disease\n* Type 1 and 2 diabetes\n* Endocrine disease\n* Hypertension\n* Musculoskeletal disease\n* Peripheral occlusion\n* Hepatic disease\n* Have had weight fluctuations exceeding + 3% in the previous 12 months\n* On medications which alter carbohydrate metabolism will not be studied","ALL","18 Years","50 Years",{"count":18,"type":19},100,"ESTIMATED","OBSERVATIONAL","The focus of this proposal is on overweight (25\\>BMI\\\u003C30 kg\u002Fm2) subjects, as these individuals exhibit a high risk of becoming obese and\u002For developing metabolic diseases. We hypothesize that in some overweight individuals there is a \"metabolic program\" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.",[23],"Metabolic Inflexibility",[23,25,26],"Obesity","Anaerobic glycolysis","RECRUITING","2025-08-04",{"date":30,"type":31},"2025-08-07","ACTUAL",{"date":33,"type":31},"2020-03-03",{"date":35,"type":19},"2025-12",{"name":37,"class":38},"East Carolina University","OTHER",""]