[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"methadone-overdose\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:methadone-overdose":60},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100580459",false,"NCT06837571","Methadone Dose Monitoring With a Remote Medication Monitor","Assessment of Methadone Dose Taken","Inclusion Criteria:\n\n* Age 18-70\n* A prescription for methadone at a dose of 10mg or more for at least one week.\n* Taking methadone as prescribed during the last 4 days before consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>70\n* A condition preventing or complicating ISF collection\n* dermatological (skin) condition\n* immunodeficiency\n* recent blood donation\n* anemia\n* end stage renal disease\n* liver cirrhosis\n* cancer\n* congestive heart failure\n* bleeding diathesis\n* tuberculosis (TB)\n* Any active severe depression\n* suicidal ideation\n* mania symptoms\n* Pregnancy\n* Intending to become pregnant during the course of the study\n* Enrolled in a substance use disorder treatment program\n* Under a conservatorship.","ALL","18 Years","70 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","Proof of concept: Pilot Study\n\nA Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone levels in interstitial fluid (ISF). An RMM could be used as a medication adherence monitor and would allow for the physician, counselor, patient, or family member to remotely verify that a physician-prescribed dose has been taken.",[24,25,26,27,28],"Methadone Toxicity","Methadone Overdose","Pain, Chronic","Drug Metabolism, Poor, CYP2D6-Related","Metabolism Medication Toxicity",[30],"Pharmacokinetics","NOT_YET_RECRUITING","2025-02-15",{"date":34,"type":35},"2025-02-20","ACTUAL",{"date":37,"type":20},"2025-04-26",{"date":39,"type":20},"2025-06",{"name":41,"class":42},"Cari Health Inc.","OTHER",1,{"id":45,"slug":4,"hasResults":10,"nctId":46,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":49,"keywords":50,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":43},"100514674","NCT05981573","Inclusion Criteria:\n\n* Age 18-70\n* A prescription for methadone for chronic pain at a dose of 10mg or more for at least one week.\n* Taking methadone as prescribed during the last 4 days before consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>70\n* A condition preventing or complicating ISF collection\n* dermatological (skin) condition\n* immunodeficiency\n* recent blood donation\n* anemia\n* end stage renal disease\n* liver cirrhosis\n* cancer\n* congestive heart failure\n* bleeding diathesis\n* tuberculosis (TB)\n* Any active severe depression\n* suicidal ideation\n* mania symptoms\n* Pregnancy\n* Intending to become pregnant during the course of the study\n* Enrolled in a substance use disorder treatment program\n* Under a conservatorship.",{"count":19,"type":20},[24,25,26,27,28],[30],"RECRUITING","2025-02-11",{"date":54,"type":35},"2025-02-13",{"date":56,"type":35},"2024-08-26",{"date":58,"type":20},"2026-04",{"name":41,"class":42},""]