[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"mucus-retention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:mucus-retention":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100553817",false,"NCT06491017","Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Wet Mucus Volume During Invasive Ventilation","Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Suctioned Wet Mucus Volume During Invasive Ventilation","Inclusion Criteria:\n\n* Adults (\\> 18yo).\n* Endotracheal intubation and invasive mechanical ventilation for \\> 48h and active humidification for \\> 24h.\n* Richmond Agitation-Sedation Scale -3 to -5.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Patients with hemodynamic instability (MAP \\\u003C 60 or \\> 110, Heart Rate \\\u003C 50 or \\> 130, new onset arrhythmias), respiratory instability (PEEP \\> 12cmH2O, SpO2 \\\u003C 90% or fraction of inspired oxygen (FiO2) \\> 60%).\n* Undrained pneumothorax\u002Fpneumomediastinum.\n* Unstable intracranial pressure (ICP \\> 20mmHg or MAP \\\u003C 60).\n* Severe bronchospasm.\n* Post cardiothoracic surgical patients.\n* Active pulmonary tuberculosis.\n* Bronchoesophageal or bronchopleural fistulas.\n* Prone position.\n* Pregnancy.",true,"ALL","18 Years",{"count":19,"type":20},26,"ESTIMATED","INTERVENTIONAL",[23],"NA","Retention of airway secretions is a frequent complication in critically ill patients requiring invasive mechanical ventilation (MV).This complication is often due to excessive secretion production and ineffective secretion clearance.\n\nMechanical insufflator-exsufflator (MI-E) is a respiratory physiotherapy technique that aims to assist or simulate a normal cough by using an electro-mechanical dedicated device. A positive airway pressure is delivered to the airways, in order to hyperinflate the lungs, followed by a rapid change to negative pressure that promotes a rapid exhalation and enhances peak expiratory flows.\n\nHowever, there is no consensus on the best MI-E settings to facilitate secretion clearance in these patients. Inspiratory and expiratory pressures of ±40 cmH2O and inspiratory-expiratory time of 3 and 2 seconds, respectively, are often used as a standard for MI-E programming in the daily routine practice, but recent laboratory studies have shown significant benefits when MI-E setting is optimized to promote an expiratory flow bias.\n\nThe investigators designed this study to compare the effects of MI-E with an optimized setting versus a standard setting on the wet volume of suctioned sputum in intubated critically ill patients on invasive MV for more than 48 hours.",[26,27],"Mucus Retention","Mechanical Ventilation Complication",[29,30,31,32],"Mechanical insufflation-exsufflation","Physiotherapy","Mucus retention","mechanical ventilation","RECRUITING","2026-05-07",{"date":36,"type":37},"2026-05-08","ACTUAL",{"date":36,"type":37},{"date":40,"type":20},"2028-12",{"name":42,"class":43},"Hospital Clinic of Barcelona","OTHER",""]