[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multidetector-computed-tomography\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multidetector-computed-tomography":117},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,58],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":36,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100562453",false,"NCT06603363","Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CT","INTENSE","Inclusion Criteria:\n\n* patients referred for coronary computed tomography angiography (CTA)\n* females aged 45-75 years and males aged 40-75 years\n* presence of at least mild coronary atherosclerosis (luminal stenosis \\>25%, with at least one partially calcified or non-calcified plaque)\n* statin-naive patients\n* ability to understand and provide written informed consent\n* FFR-CT value ≥0.75, indicating the absence of hemodynamically significant stenosis\n\nExclusion Criteria:\n\n* contraindications to coronary CTA\n* current or prior treatment with statins or other lipid-lowering agents (e.g., ezetimibe)\n* age below 45 years in females or below 40 years in males\n* age above 75 years in both sexes\n* pregnancy or breastfeeding\n* type 1 or type 2 diabetes mellitus\n* history of coronary stent implantation or coronary artery bypass grafting\n* history of myocardial infarction\n* ≥70% luminal stenosis in the proximal left anterior descending artery (LAD), or ≥50% stenosis in the left main (LM) coronary artery\n* FFR-CT value \\\u003C0.75 in any coronary artery\n* elevated serum alanine aminotransferase (ALT) levels (\\>3× the upper limit of normal)\n* elevated serum creatine kinase (CK) levels (\\>3× the upper limit of normal)\n* LDL cholesterol level \\>5 mmol\u002FL\n* renal failure or significantly impaired renal function (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²)\n* ongoing oncological treatment\n* active liver disease\n* known hypersensitivity to any excipients of the investigational product\n* concomitant treatment with the combination of sofosbuvir\u002Fvelpatasvir\u002Fvoxilaprevir\n* concomitant treatment with cyclosporine\n* women of childbearing potential not using adequate contraception\n* presence of myopathy","ALL","45 Years","75 Years",{"count":19,"type":20},140,"ESTIMATED","INTERVENTIONAL",[23],"NA","INTENSE Trial is a prospective, double-blind, randomized, placebo-controlled, single-center study with two arms (40 mg intensified statin therapy vs matching placebo for rosuvastatin) among statin-naive patients referred to coronary CT angiography due to stable chest pain, followed for 24 months by using a photon-counting detector CT (PCD-CT).\n\nINTENSE Trial aims 1) to assess the effect of short-term intensified statin therapy on coronary anatomy and physiology using PCD-CT and 2) to determine the impact of short-term, intensified statin therapy on coronary plaque morphology and hemodynamics to identify statin responder and non-responder patients in addition to testing the hypothesis of \"plaque memory\" after the 24-month follow-up period.",[26,27,28,29,30,31,32,33,34,35],"Coronary Artery Disease","Atherosclerotic Plaque","Coronary Computed Tomography Angiography","Statin Therapy","Multidetector Computed Tomography","Heart Diseases","Cardiovascular Diseases","Arteriosclerosis","Vascular Diseases","Hyperlipidemia",[37,38,39,40,41,42,43,44],"coronary artery disease","stable chest pain","intermediate pretest probability","explanatory randomised controlled trial","coronary computed tomography angiography","photon-counting detector CT","atherosclerotic plaque","statin therapy","RECRUITING","2026-05-08",{"date":48,"type":49},"2026-05-13","ACTUAL",{"date":51,"type":49},"2025-05-28",{"date":53,"type":20},"2028-12-15",{"name":55,"class":56},"Prof. Maurovich-Horvat Pál","OTHER",1,{"id":59,"slug":4,"hasResults":10,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":10,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":21,"phases":67,"briefSummary":68,"conditions":69,"keywords":80,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":116},"100523911","NCT06101862","Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome","Team-based Interventional Triage in Acute Coronary Syndrome Based on Non-Invasive Computed Tomography Coronary Angiography - a Randomized Trial","TRACTION","Inclusion criteria:\n\n* Admitted with non-ST-segment elevation myocardial infarction or unstable angina pectoris and an indication for subacute ICA\n* Elevated troponin or ischemic electrocardiographic changes\n* Written informed consent\n\nExclusion criteria:\n\n* Instability requiring acute or emergent ICA\n* History of percutaneous coronary intervention or coronary artery bypass grafting\n* Estimated glomerular filtration rate \\< 30 mL\u002Fmin\u002F1.73m2\n* Probable type 2 acute myocardial infarction\n* Severe valvular heart disease as primary diagnosis or potential need for valve intervention\n* History of spontaneous coronary artery dissection\n* Expected poor quality of the CCTA\n* Prior CCTA or ICA during index admission or within 1 week\n* Known allergy to beta-blockers or contrast agent\n* Pregnant or nursing\n* Previously randomized in this trial",{"count":66,"type":20},2300,[23],"Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS).\n\nIf CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.",[70,71,72,73,74,75,76,77,78,26,30,79],"Ischemic Heart Disease","Non STEMI","Angina Pectoris, Unstable","Coronary Disease","Heart Attack","Acute Myocardial Infarction (AMI)","Randomized Controlled Trial","Diagnostic Imaging","Coronary Stenoses","Percutaneous Coronary Intervention",[81,82,83,84,85,86,87,88,63,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106],"Angiography","Computed Tomography","Coronary","Non-STEACS","CCTA","ICA","Randomized","Interventional Triage","Diagnostic imaging","Interventional cardiology","VERDICT","CT","Coronary Angiography","Complications","Coronary CT-team","Ischemic heart disease","Acute myocardial infarction","Non-ST-elevation myocardial infarction (NSTEMI)","Unstable angina pectoris","Percutaneous coronary intervention","Coronary artery bypass grafting","PCI","CABG","Diagnostic procedure","Interhospital transfers","Myocardial Ischemia","2025-02-14",{"date":109,"type":49},"2025-02-19",{"date":111,"type":49},"2023-10-01",{"date":113,"type":20},"2036-10-01",{"name":115,"class":56},"Rigshospitalet, Denmark",6,""]