[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multimorbidity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multimorbidity":572},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,47,78,105,137,165,199,231,267,294,318,352,384,415,439,466,492,521,547],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100549278",false,"NCT06431932","Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity","Pharmacokinetics, Safety, and Efficacy of Fisetin - A Phase I and Pilot Phase IIa Study","Fisetin HIGH","Healthy volunteers:\n\nInclusion Criteria:\n\n* Aged 20-35 years\n* suPAR levels \\\u003C3.5 ng\u002FmL (± 15% corresponding to assay variation)\n* Able to cooperate cognitively\n* Able to read and understand Danish\n* Women of childbearing potential must use effective contraception\n\nExclusion Criteria:\n\n* Body weight \\>100 kg\n* Inability to swallow pills\n* Pregnant and\u002For lactating\n* Known hypersensitivity or allergy to fisetin or excipients in the placebo capsules\n* Presence of any condition that the investigator believes would put the subject at risk or would preclude the participant from successfully completing all aspects of the trial\n* Presence of known chronic diagnosis\n* Active acute illness\n* Prescribed medication, except contraceptives\n* Previous cancer diagnosis or treatment\n* Use of senolytic and other \"anti-aging\" supplements\n\nOlder patients with multimorbidity:\n\nInclusion Criteria:\n\nAt screening #1 during hospital admission:\n\n* Acutely hospitalized medical patient\n* Age ≥65 years\n* suPAR \\>5 ng\u002FmL (± 15% corresponding to assay variation)\n* Multimorbidity (≥2 chronic diagnoses)\n* Able to cooperate cognitively\n* Able to read and understand Danish\n\nAt screening #2 28 days after hospital discharge:\n\n* suPAR \\>5 ng\u002FmL (± 15% corresponding to assay variation)\n\nExclusion Criteria:\n\nAt screening #1 during hospital admission:\n\n* Body weight \\>100 kg\n* Inability to swallow pills\n* Known human immunodeficiency virus infection, active hepatitis B or C infection, invasive fungal infection\n* Uncontrolled (as per clinical judgment) pleural\u002Fpericardial effusions or ascites\n* New\u002Factive invasive cancer except non-melanoma skin cancers\n* Active cancer treatment or disseminated cancer\n* Known condition associated with major immunodeficiency\n* Known hypersensitivity or allergy to fisetin or excipients in the placebo capsules\n* Use of senolytic and other \"anti-aging\" supplements\n\nAt screening #2 28 days after hospital discharge:\n\n* Body weight \\>100 kg\n* CRP \\>30 mg\u002FL (± 15% corresponding to assay variation)\n* Inability to swallow pills\n* Presence of any condition, or abnormal routine biochemistry test, that the investigator believes would put the subject at risk or would preclude the patient from successfully completing all aspects of the trial\n* Unstable (as per clinical judgment) major disorders, e.g., cardiovascular, renal, endocrine, immunological, hepatic disorder, or cancer\n* Estimated glomerular filtration rate (eGFR) \\\u003C15 ml\u002Fmin\u002F1.73 m2 or as per clinical judgment (e.g., risk of acute kidney injury)\n* Human immunodeficiency virus infection, known active hepatitis B or C infection, invasive fungal infection\n* Uncontrolled (as per clinical judgment) pleural\u002Fpericardial effusions or ascites\n* New\u002Factive invasive cancer except non-melanoma skin cancers\n* Active cancer treatment or disseminated cancer\n* Known condition associated with major immunodeficiency\n* Known hypersensitivity or allergy to fisetin or excipients in the placebo capsules\n* Subjects taking strong inhibitors or inducers of CYP3A4 or as per clinical judgment\n* Subjects taking specified substrates with a narrow therapeutic range for CYP3A4 or as per clinical judgment\n* Subjects taking specified inhibitors, inducers, or substrates of CYP2D6, CYP2C9, or CYP2C8, or as per clinical judgment\n* Subjects regularly using drug classes or specific medications or as per clinical judgment\n* Use of senolytic and other \"anti-aging\" supplements",true,"ALL","20 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","The accumulation of senescent cells with age is a central mechanism that contributes to the development of chronic diseases, primarily by driving systemic chronic inflammation. Senolytic compounds such as fisetin can selectively target senescent cells for elimination and reduce multiple age-related pathologies in animal models.\n\nWe will conduct a clinical trial in healthy volunteers and older patients with multiple chronic diseases. The participants will receive fisetin or placebo for two days, after which they will be examined at regular intervals for up to three months. We will investigate how fisetin is absorbed and metabolized by the body, and whether fisetin is safe. We will also identify methods to best measure the effect of fisetin on chronic inflammation, senescent cells, and general health.",[28,29],"Multimorbidity","Healthy",[31,32,33],"Senolytic","Pharmacokinetics","Chronic inflammation","RECRUITING","2026-05-16",{"date":37,"type":38},"2026-05-19","ACTUAL",{"date":40,"type":38},"2026-03-24",{"date":42,"type":21},"2028-12-31",{"name":44,"class":45},"Ove Andersen","OTHER",1,{"id":48,"slug":4,"hasResults":10,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":10,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100605144","NCT07158697","Health Chat for Empowerment-based Lifestyle Planning for Cardiometabolic Multimorbidity","Health Chat for Empowerment-based Lifestyle Planning for Cardiometabolic Multimorbidity (HcELP_CMM) Program: a Randomized Controlled Trial Study","HcELP_CMM","Inclusion Criteria:\n\n1. Adults aged 18 years or above；\n2. Diagnosed with cardiometabolic multimorbidity (CMM), which was defined as co-existing with two or more cardiometabolic diseases, including primary hypertension, type 2 diabetes, stroke, heart diseases (eg. coronary heart disease, arrhythmia, heart failure, myocardial infarction, and cardiac valve diseases), dyslipidemia, and obesity;\n3. Possessed a digital device installed with WeChat, as well as with an internet connection.\n\nExclusion Criteria:\n\n1. Contraindications to exercise according to American College of Sports Medicine (ACSM), such as severe musculoskeletal disorders, severe cardiovascular diseases, or spinal nerve injury;\n2. Diagnosis of psychiatric disease;\n3. Has impaired cognitive function as indicated by an Abbreviated Mental Test Score (AMTS) ≤6;\n4. Has impaired sensory or communication function which hider them participation in this program, such as hearing loss, vision loss, and unable to speak Mandarin.","18 Years",{"count":56,"type":21},232,[58],"NA","The goal of this study is to:\n\n1. assess the feasibility, acceptability, and the preliminary effects of the health chat for empowerment-based lifestyle planning for CMM (HcELP\\_CMM);\n2. examine the short-term effects of the HcELP\\_CMM program on lifestyle behaviors, cardiometabolic indicators, symptom burden, health related quality of life (HRQoL), psychological well-being, and physical function in patients with CMM;\n3. examine the long-term effects of the HcELP\\_CMM program on lifestyle behaviors, cardiometabolic indicators, symptom burden, HRQoL, psychological well-being, and physical function in patients with CMM.\n\nThe main questions it aims to answer are:\n\n1. If the HcELP\\_CMM program is feasible and acceptable?\n2. If the HcELP\\_CMM program has the potential to improve the lifestyle behaviors, cardiometabolic indicators, symptom burden, HRQoL, psychological well-being, and physical function in patients with CMM compared to the usual care group in the short-term？\n3. If the HcELP\\_CMM program has the potential to improve the lifestyle behaviors, cardiometabolic indicators, symptom burden, HRQoL, psychological well-being, and physical function in patients with CMM compared to the usual care group in the long-term？",[61,28],"Cardiometabolic Diseases",[63,64,65,66,67],"Cardiometabolic multimorbidity","Empowerment","Patient-centered","Self-management","Intervention","2026-05-06",{"date":70,"type":38},"2026-05-11",{"date":72,"type":38},"2025-09-08",{"date":74,"type":21},"2027-02-05",{"name":76,"class":45},"The University of Hong Kong",3,{"id":79,"slug":4,"hasResults":10,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":10,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100634924","NCT07546006","Navigation for Elderly People With Multiple Morbidity After Hospital Discharge.","NAVIM","Inclusion Criteria:\n\n* Elderly individuals aged 60 or older;\n* With confirmed multimorbidity documented in their medical records;\n* Hospitalized in the SUS (Unified Health System) clinical units (5th North, 6th North, and 7th North), regardless of specialty;\n* Who will be discharged home;\n* Have telephone access and have a primary caregiver responsible for assisting with communication, in cases where the elderly person is unable to respond for themselves.\n\nExclusion Criteria:\n\n* Elderly people hospitalized in restricted access clinical units (6th south), and those with private insurance or paying out-of-pocket (4th south);\n* Those transferred to another hospital service or to other institutions;\n* Patients who are already receiving or will receive navigation care or other safe discharge follow-up care;\n* Patients in palliative care.","60 Years",{"count":86,"type":21},148,[58],"This research aims to create and test a tracking (navigation) model to assist in providing care guidance to elderly people (60 years or older) who have two or more chronic diseases at the same time (multimorbidity) immediately after being discharged from the hospital.",[28],[91,92,28,93,94],"Aged","Patient Navigation.","Comprehensive Health Care","Geriatric Nursing","NOT_YET_RECRUITING","2026-04-15",{"date":98,"type":38},"2026-04-22",{"date":100,"type":21},"2026-06-01",{"date":102,"type":21},"2028-03-30",{"name":104,"class":45},"Hospital de Clinicas de Porto Alegre",{"id":106,"slug":4,"hasResults":10,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":10,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":120,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":46},"100562641","NCT06605807","Optimizing Prescribing Decisions for Hospitalized Older Adults With Chronic Conditions","Optimizing Prescribing Decisions for Hospitalized Older Adults With Chronic Conditions: Aim 3","Clinician Participants:\n\nInclusion Criteria:\n\n1. Attending clinicians who practice on the general medicine or hospital medicine service at UPMC Presbyterian, UPMC Montefiore, UPMC Shadyside, UPMC Mercy, or UPMC Magee-Women's Hospital campuses.\n2. Practicing on the general medicine or hospital medicine service. This population may include physicians with training in general internal medicine, hospital medicine, family practice, internal medicine subspecialities, as well as advance practice clinicians.\n\nExclusion Criteria:\n\n1. Anticipating leaving current clinical position within next 3 months\n2. Less than 4 weeks of inpatient attending service scheduled within 3 months of recruitment\n\nPatient Participants:\n\nInclusion Criteria:\n\n1. Adult aged 65 years or older who are hospitalized under the care of a participating clinician and discharged home.\n2. Eligible patients must recieve at least one cardiometabolic medication change at hospital discharge (can include new medication starts, stops, or dose changes). Cardiometabolic medications include any class of antihypertensive, lipid lowering, anti-platelet, or glucose lowering medications regardless of indication for use.\n\nExclusion Criteria:\n\n1. Incapacity for informed consent \u002F unable to answer survey questions due to cognitive impairment\n2. Enrolled in hospice care",{"count":112,"type":21},150,[58],"The goal of this pilot clinical trial is to learn if providing a clinical decision framework for managing older adults chronic conditions during hospitalization to inpatient clinicians improves clinicians' ability to individualize chronic condition prescribing decisions for hospitalized older adults (65 and older). The main questions it aims to answer are:\n\n* Will the clinical decision framework lead to clinicians having greater confidence to individualize discharge prescribing?\n* Will clinicians using the framework discharge make fewer changes to hospitalized older adults with home diabetes and hypertension medications than they did prior to receiving the framework?\n* Will older adult patients of participating clinicians will report fewer gaps in understanding of medication changes after the clinician is exposed to the framework?\n\nResearchers will compare participating clinician survey responses and prescribing records from before and after an educational session presenting the clinical decision framework.\n\nParticipants will be asked to\n\n* Attend a one-time educational session on the clinical decision framework\n* Complete 2 electronic surveys, one before and one following the educational session.\n* Agree for researchers to contact their patients, in order for patients to complete a one-time phone survey about changes made to home medications during hospitalization and quality of communication from the hospital team.",[116,117,28,118,119],"Prescribing Decisions","Diabetes","Hypertension","Geriatrics",[121,122,123,124,125,126,127],"prescribing","hypertension","diabetes","geriatrics","polypharmacy","multimorbidity","hospital medicine","2026-04-08",{"date":130,"type":38},"2026-04-14",{"date":132,"type":38},"2025-11-13",{"date":134,"type":21},"2027-01-30",{"name":136,"class":45},"University of Pittsburgh",{"id":138,"slug":4,"hasResults":10,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":10,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":46},"100538254","NCT06288438","Multicomponent Telerehabilitation to Engage Veterans in Effective Self-Management of Complex Health Conditions","Multicomponent Telerehabilitation to Engage Veterans in Effective Self-Management of ComplexHealth Conditions","Inclusion Criteria:\n\n* 60 years of age and older\n* Multiple chronic conditions (Functional Comorbidity Index \\> or = 3)\n* Impaired physical function (\\\u003C or = 8 repetitions on 30 second sit to stand test)\n\nExclusion Criteria:\n\n* Life expectancy \\\u003C 12 months\n* Acute or progressive neurological disorder (e.g. amyotrophic lateral sclerosis, recent stroke)\n* Moderate to severe dementia (\\\u003C11 on telephone Montreal Cognitive Assessment(T-MoCA))\n* Medical conditions precluding safe participation in high-intensity rehabilitation (e.g. unstable angina)",{"count":144,"type":21},126,[58],"Medically complex older Veterans are at greater risk for progressive declines in physical function, lower quality of life, and increasing care needs. Additionally, older Veterans experience social isolation and loneliness, and have low levels of physical activity. While the Veterans Health Administration has established programs to address rehabilitation needs, these programs tend to be diagnosis-focused, lack self-management approaches, include low-intensity rehabilitation, and typically require in-person attendance. A MultiComponent TeleRehabilitation (MCTR) program that includes high-intensity rehabilitation and self-management interventions, social support, and telehealth and technology supports may be more effective in improving and sustaining physical function for older Veterans with complex health conditions. Therefore, this project is designed to determine whether the MCTR program improves strength and physical function more effectively than traditional interventions.",[28,148],"Physical Deconditioning",[150,151,152,153,154],"telerehabilitation","high intensity","biobehavioral","social support","physical activity","2026-02-20",{"date":157,"type":38},"2026-02-24",{"date":159,"type":38},"2024-04-18",{"date":161,"type":21},"2028-03-31",{"name":163,"class":164},"VA Office of Research and Development","FED",{"id":166,"slug":4,"hasResults":10,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":10,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":22,"phases":174,"briefSummary":175,"conditions":176,"keywords":184,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":4},"100625231","NCT07419945","Older Kidney Patient Optimisation Pretransplant","Optimising Access to and Outcomes From Transplantation in Older Potential Kidney Transplant Recipients: Pilot Feasibility Study on Kidney Transplant-specific Comprehensive Geriatric Assessment (KT-CGA)","OK-POP","Inclusion Criteria:\n\n* Adults aged 60 years or older\n* Attending Guy's and St Thomas' (GSTT) Nephrology services\n* Diagnosed with Chronic Kidney Disease (CKD) Stage 5\n\nEither:\n\n* Pre-dialysis, or\n* Receiving dialysis (in-centre haemodialysis, peritoneal dialysis, or home haemodialysis)\n* Referred to the kidney transplant surgical clinic for assessment of suitability for kidney transplantation (pre-transplant evaluation)\n\nExclusion Criteria:\n\n* Adults aged under 60 years\n* Patients currently attending the Nephrology Supportive Care service at GSTT",{"count":173,"type":21},50,[58],"The goal of this clinical trial is to learn if a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve the way older adults are assessed for kidney transplantation. The main questions it aims to answer are:\n\nIs it feasible and acceptable to deliver a KT-CGA alongside routine transplant assessment in older adults with advanced kidney disease?\n\nWhat is the effect of KT-CGA on decision-making about transplant listing and on patient-reported outcomes such as quality of life and frailty?\n\nResearchers will compare participants who receive the KT-CGA plus usual care to those who receive usual care alone.\n\nParticipants will:\n\nContinue with their usual transplant assessment process\n\nIf randomised to the intervention group, also complete the KT-CGA (a structured set of questionnaires, short memory and function tests, and discussions about wellbeing and support needs, taking about 45-60 minutes)",[177,178,179,180,28,181,182,183],"Kidney Disease","Kidney Failure","Frailty","Cognitive Impairment","End Stage Kidney Disease (ESRD)","Kidney Transplant","Health Inequity",[185,186,126,187,188,189],"kidney transplant","frailty","cognitive impairment","end stage kidney disease","health inequality","2026-02-12",{"date":192,"type":38},"2026-02-19",{"date":194,"type":21},"2026-02-02",{"date":196,"type":21},"2028-02-02",{"name":198,"class":45},"Guy's and St Thomas' NHS Foundation Trust",{"id":200,"slug":4,"hasResults":10,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":10,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":206,"targetDuration":4,"studyType":22,"phases":208,"briefSummary":209,"conditions":210,"keywords":214,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":230},"100605772","NCT07166861","Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2","Supporting Practices In Respecting Elders Phase 2","SPIRE2","Patient Inclusion Criteria:\n\n* Age 65 years or older\n* Eligible for an AWV (Medicare\u002FMedicare Advantage) during the study period\n* Residential mailing address within a radius of the practice that can be achievably reached via a home visit\n* English or Spanish speaking\n* Be able to provide consent and \u002F or have a proxy able to consent to study participation.\n* Meet criteria for complex health care needs, by virtue of having a Probability of Repeated Admissions (PRA) score of 0.35 or greater AND\u002FOR Kim Syndrome on Aging (efrailty indicator) score of 0.35 or greater\n\nCaregiver Inclusion Criteria:\n\n* Age 18 years or older\n* English or Spanish speaking\n* Be able to provide consent to study participation\n* Be identified by an eligible patient for participation in the study\n\nClinician Inclusion Criteria:\n\n* Age 18 years or older\n* English or Spanish speaking\n* Be able to provide consent to study participation\n* Adult health professionals who work at participating ACOs and primary care practice sites (e.g. physicians, advanced practice clinicians, nurses, social workers, clinic staff.)",{"count":207,"type":21},6080,[58],"This study consists of three aims focused on examining the feasibility of adding the Geriatric Resources and Assessment for the Care of Elders (GRACE) model to structured Annual Wellness Visits (AWVs) to improve patient and caregiver outcomes and reduce hospitalizations in older adults with complex health needs. The objectives are to:\n\n1. Co-design a community-centric implementation strategy for the AWVs vs AWVs + GRACE -augmented care (AWV GRACE) study arms\n2. Develop a referral pathway and algorithm to optimize enrollment of eligible participants\n3. Conduct a pilot clinical trial to assess the feasibility of the AWV GRACE intervention.",[211,212,28,213],"Aging","Preventive Care","Palliative Care",[215,216,217,218,219,220],"annual wellness visit","geriatric collaborative care","complex care needs","geriatric assessment","implementation","comparative effectiveness","2026-01-20",{"date":223,"type":38},"2026-01-22",{"date":225,"type":38},"2026-01-06",{"date":227,"type":21},"2030-01",{"name":229,"class":45},"Massachusetts General Hospital",4,{"id":232,"slug":4,"hasResults":10,"nctId":233,"briefTitle":234,"officialTitle":234,"acronym":235,"eligibilityCriteria":236,"healthyVolunteers":10,"sex":17,"minAge":237,"maxAge":4,"enrollmentInfo":238,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":241,"conditions":242,"keywords":248,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":46},"100609222","NCT07211750","Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT","I-CONNECT","Inclusion Criteria:\n\n* Age 65 years or older\n* Clinical diagnosis of a mood disorder (depression or bipolar disorder)\n* Currently receiving care from a psychiatrist\n* At least two chronic physical health conditions\n* Living independently at home in the Leuven region\n* Ongoing care from both a general practitioner and a psychiatrist\n\nExclusion Criteria:\n\n* Severe cognitive impairment (e.g., advanced dementia) that prevents participation in assessments or shared decision-making\n* Inability to provide informed consent","65 Years",{"count":239,"type":21},82,[58],"The goal of this clinical trial is to learn if I-CONNECT (Integrated Care for Older Adults with Major Depression and Physical Multimorbidity) can improve the health and well-being of older adults with depression or bipolar disorder and at least two chronic physical conditions, such as diabetes or high blood pressure. It will also study if the care model improves how people experience their care, lowers treatment burden, and how well the program is delivered.\n\nResearchers will compare two groups:\n\nI-CONNECT group: participants receive care coordination, a personalized care plan, medication review, shared decision-making support, and regular follow-up from a care coordinator working with their GP, psychiatrist, pharmacist, and specialists.\n\nUsual care group: participants continue with their normal healthcare from their GP and psychiatrist.\n\nParticipants will:\n\nReceive either I-CONNECT or usual care, depending on their group\n\nComplete questionnaires about their mood, quality of life, and care experience\n\nHave their healthcare use (emergency visits and hospitalizations) tracked during the study",[28,243,244,245,246,247],"Older Adults (65 Years and Older)","Mood Disorders","Depression - Major Depressive Disorder","Bipolar","Integrated Care",[249,250,251,252,253,28,254,255,256,257],"Integrated care","Care coordination","Person-centered care","Shared decision-making","Self-management support","Depression","Bipolar disorder","Older adults","Quality of life","2025-12-11",{"date":260,"type":38},"2025-12-12",{"date":262,"type":38},"2025-10-01",{"date":264,"type":21},"2027-10-30",{"name":266,"class":45},"KU Leuven",{"id":268,"slug":4,"hasResults":10,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":16,"sex":17,"minAge":272,"maxAge":273,"enrollmentInfo":274,"targetDuration":4,"studyType":22,"phases":276,"briefSummary":277,"conditions":278,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":4},"100611216","NCT07237698","A Study on the Effectiveness of Comprehensive Intervention Based on Specialized Physical Education Courses in the Prevention of Comorbidity Among Junior Middle School Students","Inclusion Criteria:\n\n* Individuals who voluntarily participate in this study and whose parents or guardians voluntarily sign the informed consent form.\n* Individuals capable of cooperating to complete measurements of all indicators throughout the entire intervention cycle.\n\nExclusion Criteria:\n\n* Individuals with eye conditions such as glaucoma, strabismus, or anisometropia.\n* Wearers of orthokeratology lenses.\n* Individuals who have undergone refractive surgery.\n* Individuals who have taken weight-loss medications or undergone weight-loss surgery.\n* Individuals with obesity caused by endocrine disorders or medication side effects.\n* Individuals with mental health disorders.\n* Individuals currently taking medications for mental health disorders.","11 Years","14 Years",{"count":275,"type":21},200,[58],"Junior high school students are in a critical period of physical and mental development, currently facing two major health challenges: first, persistently high rates of myopia with a noticeable trend toward younger onset; second, the overlapping occurrence of common conditions such as overweight\u002Fobesity, spinal deformities, and psychological anxiety.Traditional physical education classes, characterized by limited content and insufficient targeting, struggle to address these issues. Multimorbidity of common diseases in children and adolescents refers to the coexistence of two or more common diseases or chronic health problems in the same individual.\n\nTherefore, this study innovatively designed a specialized physical education curriculum integrating \"exercise + health education,\" aiming to fill the gap in comprehensive prevention and control of common adolescent health conditions through traditional physical interventions.\n\nThis study systematically investigated the effects of a specialized physical education intervention program on myopia prevention and control, as well as the simultaneous prevention of multiple common health conditions (overweight\u002Fobesity, abnormal blood pressure, insufficient cardiorespiratory fitness, abnormal spinal curvature, anxiety symptoms, and depression symptoms) among junior high school students in China. The program was designed and implemented for students at a Chinese secondary school, ultimately aiming to provide a replicable school-based physical education intervention model for adolescent health promotion. The study strictly adhered to a randomized controlled design, employing multidimensional evaluation, long-term follow-up, and rigorous quality control to ensure scientific validity and reliability of the findings.",[28,279,280,281,282,283,284],"Comorbidity","Common Diseases in Children and Adolescents","Myopia","Anxiety Symptoms","Depressive Symptoms","Overweight , Obesity","2025-11-18",{"date":287,"type":38},"2025-11-20",{"date":289,"type":21},"2025-11-15",{"date":291,"type":21},"2026-09",{"name":293,"class":45},"Xiaoyan Wu",{"id":295,"slug":4,"hasResults":10,"nctId":296,"briefTitle":297,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":10,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":300,"targetDuration":4,"studyType":302,"phases":4,"briefSummary":303,"conditions":304,"keywords":306,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":46},"100608756","NCT07205692","Multimorbidity and Cardiovascular Risk Factors After Renal Transplant","MCaRT","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Capable of giving informed consent\n* In receipt of a single organ renal transplant and being followed up by UHDB as the referring team.\n\nExclusion Criteria:\n\n• Graft failure before return to follow up",{"count":301,"type":21},30,"OBSERVATIONAL","Who can participate? Any adults over the age of 18 who have received a kidney transplant at the research centre are eligible for recruitment within the first month after transplant What does the study involve? The study involves observing and gathering data to understand how the health of people who receive a kidney transplant changes over the first year.\n\nIn particular the investigators are interested in the risk factors for heart disease and stroke, and how these change over the first year of transplant. The investigators are also interested in multiple health conditions, and how these impact patients after transplant.\n\nThere are no interventions but there will be measurements of diagnoses, risk factors for heart disease and stroke, and assessments of physical fitness Blood pressure, BMI, routine blood tests as well as assessing muscle and fat changes, how fit patients are and what new health conditions they have.\n\nWhat are the possible benefits and risks of participating? There is no active treatment or intervention, so there are no risks of benefits compared to normal care.\n\nWhere is the study run from? University Hospitals of Derby and Burton NHS trust, at the Royal Derby hospital Renal Department.\n\nWhen is the study starting and how long is it expected to run for? The study is expected to start 1\u002F9\u002F2025 and run for 2 years. Who is funding the study? The only costs of the study are funding for the staff member running the study, who is funded by the NIHR as an academic research fellow Who is the main contact? Dr Samuel Strain, Samuel.strain@nottingham.ac.uk",[182,305,28],"Cardiovascular (CV) Risk",[126,185,307,308],"renal transplant","cardiovascular risk","2025-09-25",{"date":311,"type":38},"2025-10-03",{"date":313,"type":38},"2025-09-05",{"date":315,"type":21},"2027-08-01",{"name":317,"class":45},"University Hospitals of Derby and Burton NHS Foundation Trust",{"id":319,"slug":4,"hasResults":10,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":323,"eligibilityCriteria":324,"healthyVolunteers":10,"sex":17,"minAge":54,"maxAge":325,"enrollmentInfo":326,"targetDuration":4,"studyType":22,"phases":328,"briefSummary":329,"conditions":330,"keywords":336,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":46},"100483704","NCT05578495","Association of a Digital Signature of Physical Activity and Sedentary Lifestyle With the Development of Multimorbidities in Chronic Diseases (eMOB)","Association of a Digital Signature of Physical Activity and Sedentary Lifestyle With the Development of Multimorbidities Over 4 Years of Follow-up in Chronic Diseases (eMOB) : a Prospective Cohort","eMOB","Inclusion Criteria:\n\n* Patient follow-up at CHU Clermont-Ferrand for a chronic disease in one of the following observational cohorts:\n\n  * Inflammatory rheumatic disease(rheumatoid arthritis, spondyloarthritis) included in the RCVRIC cohort (CPP Sud-Est VI N° ID-RCB- A01847-40)\n  * Pre-surgical knee and hip osteoarthritis (Evalmob) (ID-RCB N° 2019- A01017-50)\n  * Major depressive disorder included in the FACE-DR cohort (CNIL agreement: DR- 2015-673) and Bipolar disorder included in the FACE-BD cohort (CPP Ile de France IX; January 18, 2010) of the Adult Psychiatry Department B\n  * Type 2 diabetes included in the cohort of the sport medicine service \"Rehabilitation T2\" (CNIL agreement 0164)\n  * Obesity included in the \"Obesity\" sports medicine service cohort (CNIL agreement 0164)\n  * COPD included in the \"COPD Rehabilitation\" sports medicine service cohort (CNIL agreement 0164)\n  * Chronic pain cohort (eDOL) (CPP West II N° ID-RCB 2020-A02027-32)\n* Affiliation to a social security system.\n* Able to provide written informed consent to participate in the research.\n\nExclusion Criteria:\n\n* Inability to practice physical activity\n* Pregnant or breastfeeding\n* Refusal to participate\n* Minors or adults under the protection of the law or under the protection of justice.","90 Years",{"count":327,"type":21},700,[58],"Physical activity (PA) and sedentary lifestyle are determinants in the development of chronic diseases and associated quality of life alterations. PA levels are correlated with quality of life and morbidity in chronic lung disease (COPD), cardiovascular disease, diabetes, cancer, chronic inflammatory rheumatism, fibromyalgia and anxiety disorders. In these diseases, low-intensity PA often represents the main PA and the quantity of PA is correlated with health parameters.\n\nThis study aims to identify a typical profile (signature) in relation to the appearance of other chronic diseases, complications of your disease, from recording your physical activity and sedentary lifestyle by sensors evaluating very precisely the movements and taking into account the characteristics and disability related to your disease. The results of this study would therefore make it possible to identify this signature even before the appearance of complications or other diseases.",[331,332,333,334,279,28,335],"Exercise","Sedentary Behavior","Non Communicable Diseases","Comorbidities and Coexisting Conditions","Digital Technology",[337,338,339,340,28,341,342],"Physical Activity","Sedentary Lifestyle","Chronic Diseases","Comorbidities","Personal digital health","Personalized medecine","2025-09-19",{"date":345,"type":38},"2025-09-24",{"date":347,"type":38},"2023-12-07",{"date":349,"type":21},"2030-12",{"name":351,"class":45},"University Hospital, Clermont-Ferrand",{"id":353,"slug":4,"hasResults":10,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":357,"eligibilityCriteria":358,"healthyVolunteers":10,"sex":17,"minAge":237,"maxAge":4,"enrollmentInfo":359,"targetDuration":4,"studyType":22,"phases":361,"briefSummary":362,"conditions":363,"keywords":371,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":4},"100604585","NCT07151430","Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity","Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity: A Randomized Controlled Trial","COMPASS","Inclusion Criteria:\n\n1. Age ≥65 years\n2. Diagnosed with ≥2 chronic diseases or geriatric syndromes (e.g., hypertension, diabetes, frailty, depression)\n3. Willing to provide informed consent\n\nExclusion Criteria:\n\n1. Life expectancy \\\u003C1 year due to severe illness (e.g., cardiogenic shock)\n2. Currently participating in other clinical trials",{"count":360,"type":21},358,[58],"This study aims to test a new comprehensive management service package for older adults with two or more chronic conditions (multimorbidity). The package includes digital health tools, personalized guidance, and long-term management support. Researchers will compare the service package with usual care to see whether it reduces hospital readmissions, improves quality of life, and supports daily functioning. About 394 participants will be randomly assigned to either the service package group or the usual care group. Participants will be followed for 6 months to measure health outcomes, treatment adherence, and safety.",[28,118,364,365,366,367,368,180,245,369,370],"Diabetes Mellitus","Coronary Artery Disease","Dyslipidemia","Stroke","Arthritis","Chronic Kidney Disease","Chronic Liver Diseases",[372,126,373,374],"management service package","quality of life","intrinsic capacity","2025-08-28",{"date":377,"type":38},"2025-09-03",{"date":379,"type":21},"2025-12-01",{"date":381,"type":21},"2026-12-01",{"name":383,"class":45},"Xuanwu Hospital, Beijing",{"id":385,"slug":4,"hasResults":10,"nctId":386,"briefTitle":387,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":389,"targetDuration":4,"studyType":302,"phases":4,"briefSummary":391,"conditions":392,"keywords":396,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":46},"100574173","NCT06755840","Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study","Inclusion Criteria:\n\n* 1\\) Participants who were suspected of sleep disordered breathing must complete at least one overnight sleep monitoring at the Sleep Medicine Center at Xiangya Hospital.\n* 2\\) Participants can finish any assessment for each comorbid system by questionnaires, scales, physical examinations and tests, etc. independently or with the assistance.\n* 3\\) Participants agreed to participate in this study with signing an informed consent form.\n\nExclusion Criteria:\n\n* Participants who refused to participate in this study or whose clinical data was lost.",{"count":390,"type":21},15000,"Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent. Also, SDB shows high comorbidities with multisystem diseases. Furthermore, compared to patients with pure SDB, those comorbid with SDB and other disorders like cardiometabolic dysfunction and cognitive impairment experience poorer quality of life, higher rate of disease progression and mortality, and a greater economic burden. Currently, there are limited cohorts to study the associations between SDB and multisystem diseases. The aim of this study is to establish an ambispective clinical cohort for SDB in Xiangya hospital from central-south China (Xiangya Sleep Disordered Breathing Cohort, Xiangya SDB cohort) including retrospective part and prospective part, which covers multi-dimensional data of sleep monitoring, demographic, daily behaviors, clinical manifestations and comorbidities status, life quality, treatment information and evaluation, etc. by self-reported questionnaires and objective assessments and tests. Besides, whole peripheral blood is drawn for following biomarkers study and omics analysis. The main goal is to achieve precise management of SDB and related multimorbidity, containing to early identify risk individuals for multisystem impairment, significantly improve their prognosis and ultimately enhance overall health. In detail: first, to reveal how multisystem impairment related to SDB evolves; second, to identify which indicators closely involve system dysfunction due to SDB; third, to build an efficient model and a cost-effective platform to screen high-risk population and tract therapeutic effect.",[393,394,61,28,395],"Sleep Disordered Breathing (SDB)","Sleep Apnea","Neurodegenerative Diseases",[397,398,399,400,401,402,403,404,405,126],"sleep disordered breathing","obstructive sleep apnea","central sleep apnea","cardiovascular diseases","metabolic diseases","respiratory diseases","nervous system diseases","mental disorders","neoplasms","2025-04-01",{"date":408,"type":38},"2025-04-03",{"date":410,"type":38},"2025-01-15",{"date":412,"type":21},"2035-10-31",{"name":414,"class":45},"Xiangya Hospital of Central South University",{"id":416,"slug":4,"hasResults":10,"nctId":417,"briefTitle":418,"officialTitle":418,"acronym":419,"eligibilityCriteria":420,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":421,"targetDuration":4,"studyType":302,"phases":4,"briefSummary":423,"conditions":424,"keywords":427,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":46},"100583456","NCT06876558","Exploring the Multimorbidity Burden in Primary Care in Romania","MULTIMORB-PC-R","Inclusion Criteria:\n\n* Active AMBULATORY CARE medical practice in Romania.\n* Experience in managing patients with multimorbidity.\n* Willingness to participate in the study.\n\nExclusion Criteria:\n\n* None",{"count":422,"type":21},500,"Multimorbidity, the coexistence of two or more chronic conditions, is a growing challenge in primary care, significantly impacting healthcare systems worldwide. Its prevalence is rising, particularly among socioeconomically disadvantaged populations, leading to increased healthcare utilization, polypharmacy, and fragmented care. Current clinical guidelines primarily address single-disease management, failing to provide comprehensive strategies for multimorbid patients.\n\nAlthough multimorbidity has been extensively studied in Western Europe and North America, data on its burden in Romania and other Eastern European countries remain scarce. There is limited knowledge on how primary care physicians (PCPs) in Romania perceive and manage multimorbidity, particularly regarding clinical decision-making, interdisciplinary collaboration, and adherence to treatment guidelines.\n\nThis cross-sectional study aims to explore the impact of multimorbidity on Romanian PCPs, assessing their challenges in managing complex patients, their clinical and therapeutic approaches, and their level of comfort with deprescription and guideline adaptation. We will conduct a nationwide survey among primary care physicians and ambulatory specialists to evaluate the prevalence of multimorbidity in their practice, the difficulties they encounter, and potential strategies to improve care delivery.\n\nKey outcomes include the identification of multimorbidity prevalence in ambulatory settings, challenges related to consultation time and treatment complexity, barriers to interdisciplinary collaboration, and the balance between defensive and proactive medicine. Findings will provide valuable insights to guide policy changes, enhance clinical training, and promote patient-centered approaches in primary care",[28,425,426],"General Practice (GP), Primary Care Settings","Specialist Referral",[126,428,429],"priamary care","specialized care","2025-03-10",{"date":432,"type":38},"2025-03-14",{"date":434,"type":21},"2025-03-20",{"date":436,"type":21},"2025-06-01",{"name":438,"class":45},"Internist.Ro",{"id":440,"slug":4,"hasResults":10,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":444,"eligibilityCriteria":445,"healthyVolunteers":10,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":446,"targetDuration":4,"studyType":302,"phases":4,"briefSummary":447,"conditions":448,"keywords":451,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":46},"100578151","NCT06807567","Acceptability and Feasibility of Interventions for Integrated Care of Chronic Kidney Disease With Other Long-term Health Conditions in Malawi: a Qualitative Study","Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi to Inform Interventions for Earlier Detection ad Prevention (Impso Study)","Impso","Inclusion Criteria:\n\n* Eligibility criteria for each of the participant groups described above are as follows:\n\nPatients:\n\n1. Adults aged ≥ 18 years\n2. Diagnosed with CKD, or at risk of CKD, AND at least one other long-term health condition out of:\n\n   * Hypertension\n   * Diabetes mellitus\n   * HIV infection\n   * Heart failure\n   * Stroke (See Table 1 for diagnostic inclusion criteria for each of the above conditions)\n3. Receiving outpatient care at one of the selected study sites, for at least 6 months\n\nCaregivers:\n\n1. Adults aged ≥ 18 years\n2. Identified by a patient meeting the above inclusion criteria to be their primary caregiver\n\nHealthcare workers:\n\n* Adults aged ≥ 18 years\n* Currently employed as a healthcare worker at either QECH, Chiradzulu District Hospital, Ndunde Health Centre or Namadzi Health Centre.\n* Working in an outpatient clinic environments where care is delivered for patients with any of the above conditions, which may include (but is not limited to) the following:\n\n  * CKD clinic (QECH)\n  * Hypertension clinic (QECH)\n  * Diabetes clinic (QECH)\n  * HIV clinic (all study locations, including the Lighthouse clinic at QECH)\n  * Cardiology \u002Fchest clinic (QECH)\n  * General non-communicable disease (Chiradzulu District Hospital and its referring primary health centres)\n\nPolicy makers\n\n* Adults aged ≥ 18 years\n* Identified through stakeholder mapping and\u002For snowball sampling to have a leading role relevant to planning, managing and implementing services and\u002For policies for NCDs and\u002For other LTCs.\n\nExclusion Criteria:\n\n* • Under 18 years of age\n\n  * Acute physical or mental illness, which requires urgent treatment and might impact on ability to participate in and complete interview\n  * Current hospital inpatient\n  * Unable to participate in interview due to severe communication difficulties (e.g. aphasia), confusion or behavioural disturbance\n  * Declines consent",{"count":20,"type":21},"The burden of chronic kidney disease (CKD) is rising globally, but disproportionately impacting on low- and middle-income countries (LMIC) including Malawi, which have the fewest resources to manage it. Furthermore, CKD is the leading cause of catastrophic health expenditure worldwide, largely due to the extremely high costs of kidney replacement therapy (KRT) for people with kidney failure. Access to KRT remains limited in many settings, including Malawi, where there is only one nephrologist for a population of over 21 million. It is therefore essential to diagnose and treat CKD in its early stages, to facilitate earlier and more cost-effective treatment to prevent its progression to advanced disease which is associated with increased risks of kidney failure and of cardiovascular morbidity and mortality. CKD is usually asymptomatic in its early stages, so early diagnosis and treatments requires access to key diagnostic tests, in addition to strategies for channelling resources to those at the highest risk.\n\nThe causes of CKD are diverse, particularly in LMIC settings where the increasing prevalence of non-communicable diseases intersects with ongoing high burdens of infectious diseases, malnutrition, and many other social and environmental determinants of kidney health. The World Health Organization recommends integrated approaches to improve equity of quality care for people living with long-term conditions, and CKD would be amenable to integrated approaches, however CKD has been neglected from global NCD agendas and there is little data to guide the most effective methods for integrating its care with other long-term conditions (such as hypertension, diabetes and HIV infection), particularly in low-income settings such as Malawi.\n\nThe aim of this study is to explore current experiences of care for CKD and related long-term conditions, and to qualitatively evaluate the acceptability and feasibility of different potential approaches to integrating their care, amongst different stakeholders groups in Malawi.",[449,28,450],"Chronic Kidney Disease(CKD)","Long-term Health Conditions",[452,453,454,455,456],"integrated care","chronic kidney disease","long-term conditions","qualitative research","Malawi","2025-01-29",{"date":459,"type":38},"2025-02-04",{"date":461,"type":21},"2025-02-17",{"date":463,"type":21},"2026-03-05",{"name":465,"class":45},"Liverpool School of Tropical Medicine",{"id":467,"slug":4,"hasResults":10,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":471,"eligibilityCriteria":472,"healthyVolunteers":10,"sex":17,"minAge":473,"maxAge":4,"enrollmentInfo":474,"targetDuration":4,"studyType":22,"phases":476,"briefSummary":477,"conditions":478,"keywords":480,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":46},"100479744","NCT05526963","Reduction of Polypharmacy in Elderly People With Multiple Diseases","Reduction of Polypharmacy in Elderly People With Multiple Diseases - a Stepped Wedge Cluster-randomized Controlled Trial","RED","Inclusion Criteria:\n\n* ≥ 5 longterm medications (\\> 6 months) (polypharmacy)\n* ≥ 3 chronic diseases (multimorbidity)\n* ≥ 1 family doctor consultation within the last 6 months\n\nExclusion Criteria:\n\n* Patients with a critically reduced life expectancy\n* Patients who cannot autonomously visit the family practice\n* Patients who cannot participate in the informed consent process\n* Patients who are residing in a nursing home\n* Patients with dementia or a mental of behavioral disorder ICD-10 F00-F99\n* Patients who are participating in another medical study with a focus on polypharmacy or multimorbidity","70 Years",{"count":475,"type":21},1146,[58],"Elderly GP patients are often treated with five or more medications and therefore prone to adverse drug reactions (ADR). Potentially inappropriate prescriptions (PIPs) lead to increased adverse events like falls, hospitalizations and mortality. The primary aim of this study to reduce the frequency of ADRs in multimorbid patients aged 70 years and older by reducing polypharmacy.",[479,28],"Polypharmacy",[481,479,28,482],"Primary Care","Drug-Related Side Effects and Adverse Reactions","2025-01-07",{"date":485,"type":38},"2025-01-09",{"date":487,"type":38},"2024-05-30",{"date":489,"type":21},"2025-12-31",{"name":491,"class":45},"Martin-Luther-Universität Halle-Wittenberg",{"id":493,"slug":4,"hasResults":10,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":10,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":498,"targetDuration":4,"studyType":22,"phases":500,"briefSummary":501,"conditions":502,"keywords":503,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":515,"completionDateStruct":517,"leadSponsor":519,"locationsCount":46},"100572597","NCT06735339","A New Organisation of Clinic for Multimorbidity and Polypharmacy","A New Organisation of Healthcare for Multimorbidity","Inclusion Criteria:\n\n* Aged18 years or older\n* Multimorbidity: = 2 chronic conditions (minimum 6 months' duration per condition)\n* Polypharmacy (= 5 medications)\n* Complexity: Complex multimorbidity refers to the patient suffering from multiple concurrent, chronic diseases\u002Fconditions creating additional challenges. Complexity can be of physical, mental, social character and due to medication, high treatment burden, frailty, frequent healthcare visits or a special need for joint healthcare collaboration.\n\nExclusion criteria:\n\nDiagnostically unresolved conditions and patients whose primary issues require focused management of chronic pain, psychiatric disorders, alcohol misuse, and other addiction-related challenges.",{"count":499,"type":21},300,[58],"The purpose of this study is to investigate:\n\n1\\) the implementation and 2) the effects of an outpatient program for patients with complex multimorbidity. The investigators intend to integrate care from various health professionals across medical specialties and sectors, promote person-centered care, and ensure a holistic approach. Specifically, the investigators have redesigned the existing clinic, the Clinic for Multimorbidity, which has been operational since 2012 without any protocol-based evaluation. The new version introduces differentiated care options based on general practitioners needs for support.\n\nMultimorbidity, defined as the presence of two or more chronic diseases in an individual, poses a significant challenge for healthcare systems globally. There is an urgent need for targeted interventions for those with high complexity, such as due to interacting diseases and polypharmacy, particularly in light of an aging population, where on-fourth has multimorbid. Although the care for individuals with multimorbidity often may be perceived as fragmented, there is limited evidence on how to best organize the care. Effective, evidence-based strategies to ensure integration are lacking.\n\nThe population will consist of adults with complex multimorbidity from the Central Denmark Region, referred to the Clinic for Multimorbidity from general practice. Using a stepped wedge randomized controlled design, the project will encompass two studies.\n\n1. The implementation study will be based on implementation outcomes by Proctor et al: acceptability, adoption, appropriateness, feasibility, fidelity, and penetration. Data will be collected through interviews with patients and general practitioners, as well as measurements related to referral practices, costs, and feasibility.\n2. The effectiveness study will include outcome measures such as questionnaire-based patient experiences regarding health-related quality of life, treatment burden, depression, and anxiety. Additionally, the investigators will assess effects on inappropriate medication, symptoms, mortality, treatment continuity, healthcare utilization, and the initiation of health-promoting initiatives.\n\nThe investigators anticipate demonstrating that multimorbid patients will benefit from an interdisciplinary, cross-sector collaborative model. Furthermore, the investigators expect that this new organization will support general practitioners, municipalities, and hospitals in their management of these patients, addressing differentiated treatment needs in accordance with the recommendations of the Danish Health Structure Commission.",[28],[126,504,505,506,507,508,509,510,511],"continuity of care","patient pathway","Denmark","outpatient care","multidisciplinary","MDT","appropriate medicine","comorbidity","2024-12-11",{"date":514,"type":38},"2024-12-16",{"date":516,"type":21},"2025-01-05",{"date":518,"type":21},"2026-12",{"name":520,"class":45},"Central Jutland Regional Hospital",{"id":522,"slug":4,"hasResults":10,"nctId":523,"briefTitle":524,"officialTitle":524,"acronym":525,"eligibilityCriteria":526,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":527,"targetDuration":4,"studyType":302,"phases":4,"briefSummary":529,"conditions":530,"keywords":531,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":541,"completionDateStruct":543,"leadSponsor":545,"locationsCount":46},"100471612","NCT05421143","Co-design of a Seamless Person-centered Intervention to Optimize Medication Use Across Healthcare Levels","CIRCLE","Inclusion Criteria:\n\nPatients:\n\n* Adult ≥ 18 years\n* Gives written, informed consent to participate in the study. If the patient is not competent to consent, consent can be obtained from the patient's next of kin.\n* Residential address in Oslo\n* Lives at home and normally manage their medications themselves (might have help from home-care nurses or next of kin)\n* Scheduled to be discharged from the wards to their home or to short-term stay in nursing homes\n* Uses at least four regular medications from at least two therapy classes (Anatomical Therapeutic Chemical (ATC) at first level\n\nHealth care personnel (HCP) and next of kin:\n\n* Expected to be involved in the included patient's medication regime or management after hospital discharge\n* Able and willing to give written, informed consent to participate in the study\n* HCP should be general practitioners (GPs) or home-care nurses.\n\nExclusion Criteria:\n\nPatients:\n\n* Terminal and\u002For isolated due to infections\n* Has previously been included in the study\n* Has advanced cognitive failure, in accordance with assessment from treating physician\n* Will not be discharged from the included wards to their homes (for example planned transfer to another ward or long-term stay at nursing home)\n* Unable to communicate in Norwegian or English\n\nHCP and next of kin:\n\n* Unable to communicate in Norwegian or English\n* HCP or next of kin that has previously been included in the study",{"count":528,"type":21},240,"Multiple long term conditions entails various needs for complex medication treatment, which is a huge clinical challenge considering medication interactions and disease-medication interactions. It might affect quality of life, increase medical costs and needs, and cause patients to live several years with disabilities and reduced functional level. Multiple long term conditions is an important public health problem, since it is increasingly more common as the population is getting older.\n\nIt is well documented that communication problems exist between sectors in the healthcare system and that it creates an area of risk. There are many transfers that could be associated with risk for errors, as when patients are discharged from the hospital and is being transferred to the next level of care. When patients are discharged from the hospital, there is a need for transfer of correct information regarding medications. Transition of care leads to risk for medication discrepancies for the patients. Medication discrepancies are common within primary care and studies show that up to 90% of patients have at least one medication discrepancy in their lists. Different interventions have been tested to reduce medication discrepancies, but the interventions do not eliminate the need for medication reconciliations.\n\nHigher patient satisfaction have been associated with improved patient safety, clinical effectiveness, health outcomes, adherence and lower resource utilization. According to Norwegian legislation, patients or users have a right to participate in the implementation of healthcare services, e.g. the choice between available and justifiable forms of service, examination methods and treatment methods. Person-centered care (PCC) is a concept that shifts the focus away from the traditional biomedical model to personal choice by applying shared decision-making. PCC reduce symptom burden, enhance patient activation, reduce readmission rates and improve quality of life.\n\nObtaining knowledge about medication discrepancies and perceptions from patients, next of kin and healthcare personnel (HCP) after the patient's hospital discharge could contribute to a better success rate for future interventions and services. It is therefore of interest to investigate which factors that are of importance for a successful seamless person-centered intervention to optimize medication use across healthcare levels. To obtain knowledge about medication discrepancies and perceptions, the study will include both quantitative and qualitative methods, and be using a design thinking framework. The persons included will represent a wide selection with respect to, among other things, age, gender, socio-economic background, profession and diagnoses. The patients, next of kin and HCP will be included after written, informed consent.\n\nThe aim of the project is to obtain knowledge about how the investigators can strengthen patient's self-efficacy and improve the information flow when it comes to medications, in the transition between the healthcare levels. To do so, the investigators need to identify facilitators and barriers to achieve a seamless medication treatment based on the user's needs. The results will form a basis for a new, improved intervention, which follow patients during the hospital stay and further out in the primary healthcare. The aim of this project is divided into the following parts:\n\n* Investigate the frequency and type of medication discrepancies between the medication list in the discharge summary and medication use after hospital stay, to identify risk factors for which and why medication discrepancies occur in patients with multiple long term conditions.\n* Map the perceptions of patients with multiple long term conditions and next of kin regarding medication use, shared decision-making and their opinions about previously published interventions to improve medication use.\n* Evaluate HCP's perceptions regarding elements in patients with multiple long term conditions care that works well, what HCP believe do not work, with particular emphasis on the treatment with medications and transfer of care. In addition, how this care could be improved especially with the new intervention in mind.\n* Using design thinking framework to create prototypes for a new intervention\n\nOverall hypothesis for the project: Knowledge about medication discrepancies and perceptions from patients, next of kin and HCP regarding barriers and facilitators for a seamless medication treatment can contribute to an improved efficacy and implementation of the new, improved intervention.",[28],[532,533,534,535,536,537],"Person-Centered Care","Ethnography","Medications","Multiple long-term conditions","Self-efficacy","Patient preferences","2024-05-15",{"date":540,"type":38},"2024-05-16",{"date":542,"type":38},"2022-09-29",{"date":544,"type":21},"2027-04",{"name":546,"class":45},"Malin Olsen Syversen",{"id":548,"slug":4,"hasResults":10,"nctId":549,"briefTitle":550,"officialTitle":551,"acronym":552,"eligibilityCriteria":553,"healthyVolunteers":10,"sex":17,"minAge":237,"maxAge":4,"enrollmentInfo":554,"targetDuration":4,"studyType":22,"phases":556,"briefSummary":557,"conditions":558,"keywords":561,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":563,"lastUpdatePostDateStruct":564,"startDateStruct":566,"completionDateStruct":568,"leadSponsor":570,"locationsCount":46},"100530707","NCT06190288","AdvantAGE: Implementation and Evaluation of an Interprofessional Tranistional Care Model for Frail Older Adults","AdvantAGE: Implementation and Evaluation of an Interprofessional Transitional Care Model for Frail Older Adults at the University Department of Geriatric Medicine FELIX PLATTER","AdvantAGE","Inclusion Criteria:\n\n* Currently admitted to the acute or rehabilitation ward of University Department of Geriatric Medicine\n* Reside in Basel-Stadt\n* Possess the ability to speak and comprehend the German language\n* Scheduled to be discharged to their home\n* 65 years or older\n* Identified by a clinician as having a high risk of deterioration due to frailty\n\nAdditionally, participants must meet at least one of the following criteria:\n\n* diagnosed with a complex chronic disease requiring support in self-management and disease management, or\n* facing socially challenging situations such as living alone without a supportive network or lacking a GP, or\n* admitted for an acute illness with a brief hospital stay (e.g., infection, cardiac decompensation) and need support in self- and disease management, and continuity of the therapy plan, including close monitoring.\n\nExclusion Criteria:\n\n* residing in a nursing home or being newly admitted to one\n* lacking informal caregivers and exhibiting severe cognitive impairment (MMS ≤23)\n* scoring \\\u003C50 on the motoric domain of the Functional Independence Measure (FIM)\n* having a psychiatric disorder that significantly impacts their ability to manage daily life at time of the discharge",{"count":555,"type":21},250,[58],"This clinical trial at the University Department of Geriatric Medicine FELIX Platter in Basel, Switzerland, is designed to evaluate a new transitional care model aimed at helping frail older adults after they get discharged from the hospital. The AdvantAGE study aims to explore the following questions:\n\n* Does the new care model help reduce the number of patients who need to return to the hospital within 90 days?\n* How effective is the implementation of this care model?\n\nParticipants in the trial will be followed by advanced practice nurses for up to 90 days after hospital discharge. The patients and their caregivers will receive support in coordinating care, managing medications, and learning to manage the patient's health conditions on their own. Additionally, they will have the opportunity to engage in discussions about advanced care planning.",[559,28,560],"Transitional Care","Geriatric Care",[562],"Transitional Care, Frailty, Rehospitalisation, Geratric Care","2024-02-01",{"date":565,"type":38},"2024-02-02",{"date":567,"type":38},"2024-01-08",{"date":569,"type":21},"2026-06-30",{"name":571,"class":45},"Thekla Brunkert",""]