[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"multiple-primary-lung-cancers\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:multiple-primary-lung-cancers":38},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":5},"100569879",false,"NCT06699979","Multi-omics Study of Early-stage Lung Cancer With Distinct Phenotypes","Comprehensive Multi-Omics Analysis of Early-Stage Lung Cancer Exhibiting Distinct Phenotypes","Cohort 1: Multi-omics study in early-stage synchronous multiple primary lung cancer\n\nInclusion criteria:\n\n1. Male or female patients:18-75 years old;\n2. ECOG score:0-1;\n3. Histopathologically confirmed TNM stage I-II NSCLC;\n4. Considered multiple or solitary primary lung cancer by clinical criteria (Martini-Melamed criteria and ACCP criteria);\n5. Good compliance, family members agree to cooperate to receive survival follow-up;\n6. Understand and voluntarily sign the informed consent.\n\nExclusion criteria:\n\n1. A history of previous or co-existing malignant tumors;\n2. Systemic anti-tumor therapies, including chemotherapy, radiotherapy, or targeted therapies (such as monoclonal antibodies, small-molecule tyrosine kinase inhibitors, among others), were administered prior to enrollment;\n3. Refusal to participate in the study.\n\nCohort 2: Multi-omics study of lung cancer associated with cystic airspaces\n\nInclusion criteria:\n\n1. Male or female patients:18-75 years old;\n2. ECOG score:0-1;\n3. Histopathologically confirmed TNM stage I-II NSCLC;\n4. CT findings show solitary or multiple nodules with cystic airspaces.\n\nExclusion criteria:\n\n1. A history of previous or co-existing malignant tumors;\n2. Systemic anti-tumor therapies, including chemotherapy, radiotherapy, or targeted therapies (such as monoclonal antibodies, small-molecule tyrosine kinase inhibitors, among others), were administered prior to enrollment;\n3. Refusal to participate in the study.","ALL","18 Years",{"count":18,"type":19},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to investigate the multi-omics characterization early-stage lung cancer exhibiting distinct phenotypes including lung cancer associated with cystic airspaces, multiple primary lung cancers, and so on. The main questions it aims to answer are:\n\n* What are the differences in pathogenesis of non-small cell lung cancer with different phenotypes explored by multi-omics?\n* Whether differential genes lead to potential prognostic models and therapeutic targets? Participants will be followed up after surgery to answer prognosis: whether they have recurred, and the time to recurrence.",[23,24,25],"Lung Cancer Associated With Cystic Airspaces","Multiple Primary Lung Cancers","Non-Small Cell Lung Cancer","RECRUITING","2026-03-16",{"date":29,"type":30},"2026-03-18","ACTUAL",{"date":32,"type":30},"2024-08-29",{"date":34,"type":19},"2027-12-31",{"name":36,"class":37},"Central South University","OTHER",""]