[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurovascular-control\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurovascular-control":54},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":5},"100609063",false,"NCT07209683","The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults","Age-specific Neurovascular Effects of Transcranial Photobiomodulation","Inclusion Criteria:\n\n* Age: 21-85 years of age\n* Adequate hearing and visual acuity to participate in the examinations\n* Ability to read and write in English\n* Competence to provide informed consent\n\nExclusion Criteria:\n\n* Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer\n* Cerebrovascular accident other than TIA within 60 days prior to Visit 0\n* Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse\n* Participant currently uses commercial brain stimulation \u002F neuromodulation device or an experimental device as part of a research study, e.g. tDCS, tACS, TBS, DBS, TMS, TPBM, etc.\n* Participant currently takes dietary supplements with an expected cerebrovascular benefit, such as NAD- or NR-supplement, L-citrulline, urolithin\n* Unstable medical condition, including uncontrolled diabetes, chronic heart issues, heart failure, chronic obstructive pulmonary disease, Stage 2 hypertension uncontrolled by medication (\\>160\u002F100 mmHg)\n* Any other medical condition or medication which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol.\n* Pregnancy or trying to become pregnant in the next 1 months (self-reported), breastfeeding",true,"ALL","21 Years","85 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in older adults.\n\nThe main questions it aims to answer are:\n\n* Does tPBM enhance neurovascular coupling responses during memory and finger tapping tasks?\n* Are these improvements linked to better cognitive performance and lower levels of brain inflammation and oxidative stress?\n\nResearchers will compare an active tPBM treatment arm to a sham treatment arm to see if tPBM leads to measurable improvements in brain activity and cognitive function compared to no active stimulation.\n\nParticipants will:\n\n* Receive either active tPBM or sham stimulation sessions for 4 weeks, every other day using a portable intervention device.\n* Complete questionnaires and an iPAD-based cognitive testing protocol\n* Complete memory and motor tasks while their brain activity is measured using non-invasive techniques: simultaneous functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), transcranial doppler (TCD) flowmetry.\n* Retinal vessel reactivity will be measured during flickering light stimulus using a special camera (dynamic vessel analysis, DVA).\n* Provide blood samples to test for biomarkers of inflammation, oxidative stress and brain cell damage.",[27,28,29,30,31],"Cognition","Neurovascular Coupling Mechanism and Cognitive Function","Neurovascular Control","Brain Aging","Brain Activity",[33,34,35,36,37,38,39,40,41],"transcranial photobiomodulation","neurovascular coupling","aging","cognitive function","near-infrared spectroscopy","electroencephalography","dynamic vessel analysis","home-based intervention","randomized double-blinded clinical trial","RECRUITING","2026-02-04",{"date":45,"type":46},"2026-02-06","ACTUAL",{"date":48,"type":46},"2025-10-01",{"date":50,"type":21},"2026-12-31",{"name":52,"class":53},"University of Oklahoma","OTHER",""]