[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-functioning-adrenal-adenomas\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-functioning-adrenal-adenomas":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100466724",false,"NCT05357456","Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study","A Single Center, Prospective, Observational Study to Explore and Evaluate the Differences of Cognitive Function and Brain Function Between Non-functioning Adrenal Adenomas and Autonomous Cortisol Secretion Patients, and the Different Treatments Methods on Cognitive Function and Brain Function in Patients With Autonomous Cortisol Secretion","Inclusion Criteria:\n\n* age 20-65 years;\n* ≥ 6 years of education；\n* right-handed;\n* complete entire cognitive function tests;\n* adrenal lesions ≥ 1 cm in diameter;\n* patients with non-functioning adrenal adenomas;\n* patients with autonomous cortisol secretion.\n\nExclusion Criteria:\n\n* \\\u003C 6 years of education;\n* age \\\u003C 20 years or \\> 65 years;\n* maximum diameter of AI \\\u003C1cm;\n* active malignancies;\n* with a history of thyroid disease;\n* with a history of acute infection in the last month;\n* central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc;\n* contraindications of MRI examination: such as implantation of metal prosthesis in vivo, claustrophobia, etc;\n* adrenal tuberculosis;\n* suspected or diagnosed adrenocortical carcinoma;\n* unable to complete entire cognitive function tests;\n* current use of steroids or any drugs known to alter steroid synthesis or metabolism in the previous 3 months;\n* clinical Cushing syndrome;\n* Cushing disease;\n* primary hyperaldosteronism;\n* pheochromocytoma;\n* severe impairment of heart, liver, kidney and other organs;\n* pregnant and lactating women",true,"ALL","20 Years","65 Years",{"count":20,"type":21},62,"ESTIMATED","OBSERVATIONAL","This is a single center, prospective, observational study to explore and evaluate the differences on cognitive function and brain function by functional-MRI in autonomous cortisol secretion patients, and the different treatments methods on the cognitive function and brain function in patients with autonomous cortisol secretion",[25,26,27],"Autonomous Cortisol Secretion","Adrenal Incidentaloma","Non-functioning Adrenal Adenomas",[29,30,31],"cognitive function","functional MRI","treatment","RECRUITING","2022-04-27",{"date":35,"type":36},"2022-05-02","ACTUAL",{"date":38,"type":36},"2021-10-01",{"date":40,"type":21},"2026-10-01",{"name":42,"class":43},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",""]