[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-traumatic-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-traumatic-brain-injury":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100581338",false,"NCT06849011","Inflammatory and Metabolic Prognostic Assessment in Critically Ill Neurological Patients","Development and Validation of a Prognostic Prediction Model for Adverse Outcomes in Neurocritical Patients Receiving Enteral Nutrition Based on Key Inflammatory and Metabolic Markers","IMPACT-NEURO","Inclusion Criteria:\n\n1. Age between 18 and 80 years, no gender restrictions.\n2. Within 7 days of disease onset and expected NICU stay of at least 7 days.\n3. Eligible for enrollment within 24 hours of NICU admission, with enteral nutrition (EN) initiated and continued for at least 7 days.\n4. Non-traumatic severe brain injury patients (including cerebrovascular disease and encephalitis) with a Glasgow Coma Scale (GCS) score ≤12.\n5. NRS 2002 score ≥3.\n6. Kuwata drinking test ≥ grade 3.\n7. Acute Gastrointestinal Injury (AGI) grade 1 or 2.\n8. Signed informed consent obtained from the patient or their legal representative.\n\nExclusion Criteria:\n\n1. Severe malnutrition prior to admission, defined as BMI \\\u003C 16 kg\u002Fm².\n2. Pregnant or lactating women.\n3. Receiving hypothermia treatment or core body temperature \\\u003C 36°C.\n4. End-stage disease with an expected survival time of \\\u003C 48 hours, or severe dysfunction of the heart, lungs, or other vital organs, leading to hemodynamic instability.\n5. Malignant tumors.","ALL","18 Years","80 Years",{"count":20,"type":21},1185,"ESTIMATED","OBSERVATIONAL","The study aims to develop and validate a prognostic prediction model for adverse outcomes in neurocritical patients receiving enteral nutrition based on key inflammatory and metabolic markers. This model will serve as a clinical tool to help physicians identify high-risk patients and guide individualized nutritional support strategies.",[25,26,27],"Stroke Acute","Encephalitis","Non-traumatic Brain Injury",[29,30,31,32],"enteral nutrition","adverse prognosis","prediction model","non-traumatic severe brain injury","NOT_YET_RECRUITING","2025-02-23",{"date":36,"type":37},"2025-02-27","ACTUAL",{"date":39,"type":21},"2025-03-01",{"date":41,"type":21},"2027-03-31",{"name":43,"class":44},"Yan Zhang","OTHER",19,""]