[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nonsuicidal-self-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nonsuicidal-self-injury":232},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,41,75,100,119,169,191,204,217],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100610175",false,"NCT07224165","Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury","Inclusion Criteria:\n\n* Current NSSI (NSSI on 2 or more days in the last month\n* English language skills sufficient to engage in the consent and intervention procedures\n* Age 14-18\n* Access to smartphone\n\nExclusion Criteria:\n\n* Severe mental health diagnoses for which this intervention would be inappropriate (psychotic disorders, active manic episodes)\n* Severe suicide risk, including suicidal ideation with a plan and intent to act\n* Current engagement in psychotherapy","ALL","14 Years","18 Years",{"count":18,"type":19},80,"ESTIMATED","INTERVENTIONAL",[22],"NA","This is a feasibility trial of a digital mental health intervention aimed at adolescents (ages 14-18) with nonsuicidal self-injury and who are not currently engaged in mental health treatment. The study has two arms: a self-guided DMHI and an active control which will involve the delivery of non-interactive psychoeducational content via the same app interface. The primary goals of this project are to evaluate the feasibility of the intervention and trial procedures in preparation for a fully-powered randomized-controlled trial.",[25,26,27],"Nonsuicidal Self-injury","Depression","Anxiety","RECRUITING","2026-07-01",{"date":31,"type":32},"2026-07-02","ACTUAL",{"date":34,"type":32},"2026-06-04",{"date":36,"type":19},"2027-07-31",{"name":38,"class":39},"Northwestern University","OTHER",1,{"id":42,"slug":4,"hasResults":10,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":10,"sex":14,"minAge":47,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":20,"phases":50,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100643420","NCT07641283","Naltrexone for Nonsuicidal Self-Injury","A Randomized, Double-Blinded Clinical Trial to Evaluate the Effectiveness of Naltrexone in Improving Nonsuicidal Self-Injurious Behavior","Inclusion Criteria:\n\n* Participants must meet all of the following criteria:\n\n  1. Individuals aged 16 years or older.\n  2. Individuals with clinically significant nonsuicidal self-injurious behavior.\n  3. Individuals who are able to understand the study procedures and provide written informed consent. For minors, consent from a legal guardian and assent from the participant will be obtained according to applicable regulations.\n  4. Individuals who are able to comply with study procedures, including clinical visits, medication administration, and study assessments.\n  5. Women of childbearing potential must have a negative urine pregnancy test at screening and agree to use appropriate contraception during the study period.\n\nExclusion Criteria:\n\n* Participants meeting any of the following criteria will be excluded:\n\n  1. Current serious suicidal ideation or high suicide risk, as determined by the investigator.\n  2. Current opioid use, opioid dependence, or use of opioid-containing medications.\n  3. Current use of opioid antagonists or medications that may interact with naltrexone, including methadone or buprenorphine.\n  4. Use of naltrexone within 1 week before screening.\n  5. Positive naloxone challenge test or positive urine opioid test, if applicable.\n  6. Known hypersensitivity to naltrexone or any component of the investigational product.\n  7. Active liver disease, active hepatitis, or clinically significant hepatic impairment.\n  8. Clinically significant renal impairment.\n  9. Pregnancy or breastfeeding.\n  10. Intellectual disability, organic brain disorder, or other condition that may interfere with the participant's ability to understand study procedures or complete assessments.\n  11. Inability to read or write Korean sufficiently to complete study assessments.\n  12. Documented prior non-response to naltrexone for nonsuicidal self-injury, as judged by the investigator.\n  13. Any other clinically significant medical or psychiatric condition that, in the opinion of the investigator, would make participation inappropriate or unsafe.","16 Years",{"count":49,"type":19},150,[22],"This randomized, double-blinded, placebo-controlled clinical trial aims to evaluate the efficacy and safety of naltrexone in reducing nonsuicidal self-injurious behavior among individuals with nonsuicidal self-injury. Participants will be randomly assigned to receive either naltrexone plus treatment as usual or placebo plus treatment as usual for 6 weeks.\n\nThe primary objective is to determine whether naltrexone reduces the frequency of nonsuicidal self-injurious behavior compared with placebo. Secondary objectives include evaluating changes in clinical severity, suicidal ideation, self-injury-related urges, ecological momentary assessment measures, and safety outcomes.",[53,54],"Nonsuicidal Self-Injury","Self-Injurious Behavior",[56,57,58,59,60,61,62,63],"Nonsuicidal self-injury","NSSI","Self-injurious behavior","Naltrexone","Opioid antagonist","Impulsivity","Suicidal ideation","Ecological momentary assessment","NOT_YET_RECRUITING","2026-06-08",{"date":67,"type":32},"2026-06-11",{"date":69,"type":19},"2026-06",{"date":71,"type":19},"2028-06",{"name":73,"class":39},"Seoul National University Hospital",3,{"id":76,"slug":4,"hasResults":10,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":10,"sex":14,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":20,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":40},"100637007","NCT07573085","Internet-delivered Emotion Regulation Individual Therapy or Adolescents (IERITA) With Self-injury Within Child and Adolescent Mental Health Services","Inclusion Criteria:\n\n* 13-17 years old\n* At least one self-injury episode in the past three months\n* A parent willing to engage in the parent program\n\nExclusion Criteria:\n\n* Immediate suicide risk\n* Global functioning corresponding to a rating ≤40 of the Children's Global Assessment Scale (CGAS)\n* Social problems needing immediate intervention (e.g., violence within the family)\n* Ongoing dialectical behavior therapy for adolescents","13 Years","17 Years",{"count":83,"type":19},341,[22],"The overall purpose of the study is to implement and evaluate IERITA (Internet-delivered Emotion Regulation Individual Therapy for Adolescents) within child and adolescent mental health services for adolescents engaging in nonsuicidal self-injury (NSSI) and optimize treatment outcomes for those adolescents at risk of non-remission (continued NSSI).",[53,87],"Self-Harm",[56,89,90,91],"Internet-delivered treatment","Self-harm","Adolescence","2026-06-05",{"date":65,"type":32},{"date":95,"type":32},"2026-05-22",{"date":97,"type":19},"2040-12",{"name":99,"class":39},"Karolinska Institutet",{"id":101,"slug":4,"hasResults":10,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":10,"sex":14,"minAge":47,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":20,"phases":108,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":40},"100563905","NCT06622239","Trial to Evaluate the Effects of Naltrexone in Nonsuicidal Self-injury","A Randomized, Double-Blinded Clinical Trial to Evaluate the Effects of Naltrexone in Improving Nonsuicidal Self-injurious Behavior","NiNsSIB","Inclusion Criteria:\n\n* Age: 16 years of age or older\n* Clinical interviews meet DSM-5\\'s nonsuicidal self-injury diagnostic criteria\n* Nonsuicidal self-injurious behavior has been observed more than once in the past two months\n* Obsessive Compulsive Drinking Scale general craving item 2 or more points (strong desire)\n* Self-injurious behavior continues even with 4 weeks of general psychiatric treatment for underlying disease\n* Anyone who can independently read and fill out the questionnaire and speak Korean\n* Who understand the written consent and voluntarily agree to participate in the study\n* Female participants of childbearing age must be negative on urine pregnancy test at screening\n\nExclusion Criteria:\n\n* currently in psychotic or manic conditions\n* currently experiencing serious suicidal thoughts\n* history of substance-related disorders including opioid\n* do not agree to use very effective contraception from the time of signing the test subject\\'s consent form to the end of study period (non-fertility women and postmenopausal women excluded from the contraception requirements)\n* Severe medical conditions (angina pectoris, myocardial infarction, arrhythmia, any cancer that is not in remission, hypothyroidism, hyperthyroidism, diabetes, hepatitis B, hepatitis C, epilepsy, dementia, HIV infection)\n* intellectual disability or organic brain damage\n* difficulty reading and writing Korean\n* taking opioid antagonists (methadone, buprenorphine, etc.)\n* on an opiate painkiller\n* currently opiate dependence\n* acute opiate withdrawal symptoms\n* naloxone-induced test is positive or the urine test is positive for opiates\n* have been sensitized to this drug\n* acute hepatitis, liver failure, severe liver failure\n* renal disease\n* hypersensitivity reaction to the main ingredient or other ingredients of this drug\n* a pregnant woman, a woman who may be pregnant, or a lactating woman\n* Since this drug contains lactose, genetic problems such as galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption, etc\n* active liver disease",{"count":49,"type":19},[109],"PHASE2","The goal of this clinical trial is to learn if naltrexone works to treat nonsuicidal self-injurious behavior in adolescents and adults.",[53],"2026-05-20",{"date":95,"type":32},{"date":115,"type":19},"2026-06-01",{"date":117,"type":19},"2027-05-31",{"name":73,"class":39},{"id":120,"slug":4,"hasResults":10,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":10,"sex":14,"minAge":125,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":129,"conditions":130,"keywords":153,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":40},"100577917","NCT06804525","LHC-CIDI-5 in Hong Kong","Use of Life History Calendars to Enhance Measurement of Lifetime Experience With Mental Disorders in Hong Kong.","Inclusion Criteria:\n\n* All household members aged 25 years old and over are randomly sampled from the Census and Statistics Department List of Quarters\n* Live in the address sampled from the Census and Statistics Department List of Quarters\n* Reside in Hong Kong for at least six months in the past year\n* Able to read and communicate in Chinese or English\n* Without linguistic or cognitive difficulties\n\nExclusion Criteria:\n\n* Domestic workers","25 Years",{"count":127,"type":19},2500,"OBSERVATIONAL","The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12 months, and lifetime) based on the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and International Classification of Diseases 10th edition (ICD-10). However, retrospective measurements like the CIDI-5 are susceptible to recall bias, especially for the lifetime experience, which can hinder the reporting accuracy with mental disorders.\n\nTo mitigate this issue, the life history calendar (LHC) was introduced as an aid to assist respondents in recalling the timing of life events, enhancing the ability of the CIDI-5 to measure the lifetime prevalence of mental disorders. The LHC is a grid structure with columns representing time units and rows representing life domains under study.\n\nIn a study conducted in Nepal, combining the CIDI-5 with the LHC resulted in a significant increase in the detection of mental disorders compared to using the CIDI-5 alone. This approach did not lead to an increase in false positives after clinical validation.\n\nThis experiment aims to adapt a Hong Kong version of the LHC based on the Nepalese model and evaluate the effectiveness of the LHC-assisted CIDI-5 (LHC-CIDI-5) compared to the CIDI-5 alone in assessing mental disorders.",[131,132,133,134,135,136,137,53,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152],"Major Depressive Episode (MDE)","Major Depressive Disorder (MDD)","Persistent Depressive Disorder (PDD)","Suicidal Ideation","Suicidal Plan","Suicidal Attempt","Suicidal Gesture","Manic Episode","Hypomanic","Bipolar I Disorder","Bipolar Sub Disorder","Bipolar II Disorder","Generalized Anxiety Disorder (GAD)","Intermittent Explosive Disorder (IED)","Panic Attack","Panic Disorder","Obsessive-Compulsive Disorder (OCD)","Posttraumatic Stress Disorder (PTSD)","PCL-SC PTSD","PCL-5 PTSD","Alcohol Use Disorder (AUD)","Substance Use Disorder (SUD)",[154,155,156,157,158,159],"Life History Calendar","CIDI","Recall bias","Retrospective reporting","Lifetime prevalence","Mental disorders","2026-03-09",{"date":162,"type":32},"2026-03-10",{"date":164,"type":32},"2025-01-18",{"date":166,"type":19},"2027-04",{"name":168,"class":39},"The University of Hong Kong",{"id":170,"slug":4,"hasResults":10,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":175,"sex":14,"minAge":176,"maxAge":16,"enrollmentInfo":177,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":40},"100514682","NCT05981677","Social Feedback and Dysfunctional Risk Taking in NSSI Adolescents","Risk and Social Feedback in Adolescents With Nonsuicidal Self-Injury","Inclusion Criteria:\n\n* 15-18 years\n* right-handed\n* normal or corrected normal visual acuity\n* meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)\n\nExclusion Criteria:\n\n* diagnosis of borderline personality disorder, major depressive disorder, other\n* psychiatric disorders, etc.\n* high suicidal risk\n* recent use of medications that can affect neural activity\n* have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months\n* have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)",true,"15 Years",{"count":18,"type":19},"Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Problematic interpersonal relationships and decision-making have been demonstrated to play crucial roles in this maladaptive behavior, especially for adolescents. Accumulating evidence suggests that decision processes and risk-taking are strongly influenced by the affective state of the individual. However, whether these interactions are disrupted in NSSI adolescents has not been systematically examined. In the current study, the investigators modified one of the most widely used paradigms for measuring an individual's risk decision-making, the Balloon Analogue Risk Task (BART). The investigators combine social reward (green balloon), punishment (red balloon), and control feedback (yellow balloon), to investigate whether the NSSI adolescents have dysfunctional risk-taking behavior while facing different social outcomes. The investigators recruit one group of NSSI adolescents (n = 40) and one health control (HC) group (n = 40), to compare their risk-related decisions during the emotional BART. The investigators hypothesize that compared to HC, NSSI adolescents will show altered effects of social reward and punishment on risk-related decision-making, in particular higher risk avoidance in the context of social punishment.",[180,181],"Nonsuicidal Self Injury","Risk-Taking","2024-04-09",{"date":184,"type":32},"2024-04-11",{"date":186,"type":32},"2023-12-06",{"date":188,"type":19},"2027-07",{"name":190,"class":39},"University of Electronic Science and Technology of China",{"id":192,"slug":4,"hasResults":10,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":10,"sex":14,"minAge":176,"maxAge":16,"enrollmentInfo":196,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":200,"startDateStruct":201,"completionDateStruct":202,"leadSponsor":203,"locationsCount":40},"100514677","NCT05981612","Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents","Effects of Emotional Reactivity on Decision-Making in Adolescents With Nonsuicidal Self-Injury",{"count":18,"type":19},"Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.",[180,199],"Prediction Errors",{"date":184,"type":32},{"date":186,"type":32},{"date":188,"type":19},{"name":190,"class":39},{"id":205,"slug":4,"hasResults":10,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":175,"sex":14,"minAge":176,"maxAge":16,"enrollmentInfo":209,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":213,"startDateStruct":214,"completionDateStruct":215,"leadSponsor":216,"locationsCount":40},"100513656","NCT05968313","Altered Neural Pain Empathic Reactivity in NSSI Adolescents","Abnormal Neural Pain Empathic Processing in Adolescents With Non-suicidal Self-Injury",{"count":18,"type":19},"Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. In recent years, growing evidence suggests that NSSI has become a worldwide public health issue. People with NSSI behaviors, especially adolescents, commonly exhibit emotion-related and interpersonal problems. Pain empathy represents an essential basal domain of socio-emotional processing and refers to the ability to empathize, connect and share with others' pain. However, altered empathic processing has not been systematically examined in adolescents with NSSI. To this end, the current functional magnetic resonance imaging (fMRI) study will recruit one group of NSSI adolescents (n=40) and one healthy control (HC) group (n=40), to compare their neural activity regarding pain empathy processing, which is measured by blood oxygenation level-dependent (BOLD) fMRI. The investigators included conditions of physical pain empathy (stimuli depicting noxious stimulation to the limbs) and affective pain empathy (stimuli depicting faces expressing pain) as well as corresponding control stimuli. The investigators hypothesize that compared to HC, NSSI adolescents show increased empathic reactivity to physical pain stimuli in salience and arousal related brain regions but decreased empathic reactivity to affective pain empathic stimuli.",[180,212],"Pain Empathy",{"date":184,"type":32},{"date":186,"type":32},{"date":188,"type":19},{"name":190,"class":39},{"id":218,"slug":4,"hasResults":10,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":175,"sex":14,"minAge":176,"maxAge":16,"enrollmentInfo":223,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":224,"conditions":225,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":227,"startDateStruct":228,"completionDateStruct":229,"leadSponsor":231,"locationsCount":40},"100508976","NCT05907421","Emotion Regulation Dysfunctions in NSSI Adolescents in Naturalistic Contexts","Altered Neural Activation Patterns During Emotion Regulation in Adolescents With Nonsuicidal Self-Injury Under Naturalistic Immersive Emotional Engagement","Inclusion Criteria:\n\n* 15-18 years\n* right-handed\n* normal or corrected normal visual acuity\n* meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year)\n\nExclusion Criteria:\n\n* diagnosis of borderline personality disorder, major depressive disorder, other psychiatric disorders, etc.\n* high suicidal risk\n* recent use of medications that can affect neural activity\n* have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months\n* have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)",{"count":18,"type":19},"Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. Recent studies indicate that prevalence rates are increasing worldwide, in particular under adolescents, indicating a growing public health issue. An impaired ability to regulate negative emotion has been suggested to play a potential role in NSSI behavior. Some recent interventions aim at improving dysfunctional emotion regulation via 'acceptance'. Acceptance represents an objective, nonreactive, nonjudgmental, and calming emotion regulation strategy, partly based on the philosophy of dialectical behavior therapy (DBT) that has been widely used in the clinical treatment of NSSI behaviors. The aim of the present functional magnetic resonance imaging (fMRI) study is to examine whether adolescents with NSSI can implement the acceptance strategy in naturalistic emotional contexts (immersive video clips) and whether they differ from healthy controls in terms of behavioral and neural effects. To this end, the investigators recruit one group of NSSI adolescents (n=40) and one healthy control group (n=40), to compare the subjective emotional experience as well as underlying neural activity as measured by blood oxygenation level-dependent (BOLD) fMRI. The investigators hypothesize that compared to HC, NSSI adolescents will experience stronger negative emotions and show dysregulated neural recruitment of brain systems engaged in emotional reactivity and regulations (e.g. limbic regions, default mode network, and frontal regions).",[180,226],"Emotion Regulation",{"date":184,"type":32},{"date":186,"type":32},{"date":230,"type":19},"2027-06",{"name":190,"class":39},""]