[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"operable-breast-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:operable-breast-cancer":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100639113",false,"NCT07593651","EXpander-based Versus Direct to Implant PRE-pectoral Breast Reconstruction: a Comparative Analysis of Surgical Outcomes","EXpander-based Versus Direct to Implant PRE-pectoral Breast Reconstruction: a Comparative Analysis of Surgical Outcomes : the EXPRESsO Study","EXPRESSO","Inclusion Criteria:\n\n* Female patients ≥18 years\n* Patients undergoing unilateral or bilateral therapeutic mastectomy for breast cancer\n* Patients undergoing pre-pectoral implant-based breast reconstruction, either:\n\n  * One-stage DTI, or\n  * Two-stage TE-I\n* Use of implant with or without biological or synthetic mesh\n* Contralateral prophylactic mastectomy allowed if a therapeutic mastectomy was performed on one side\n\nExclusion Criteria:\n\n* Male patients\n* Subpectoral implant-based reconstruction\n* Autologous breast reconstruction\n* Delayed reconstructions not performed at the time of mastectomy\n* Incomplete clinical or follow-up data for primary endpoint analysis","FEMALE","18 Years",{"count":19,"type":20},276,"ESTIMATED","OBSERVATIONAL","Recent advances in breast surgery, together with the increasing adoption of conservative surgical approaches, have renewed interest in pre-pectoral implant-based breast reconstruction. Within this reconstructive paradigm, surgeons may employ two distinct strategies:\n\n(i) immediate reconstruction using a direct-to-implant approach (DTI), or (ii) a two-stage reconstruction consisting of tissue expander placement followed by definitive implant insertion (TE-I).\n\nEach approach is associated with specific indications, advantages, and inherent limitations.\n\nThe EXPRESSO study aims to retrospectively compare surgical outcomes between pre-pectoral DTI and TE-I breast reconstruction. By providing real-world evidence on these reconstructive strategies, this study seeks to inform surgical decision-making and to optimize reconstructive outcomes in contemporary breast cancer care.",[24,25],"Breast Cancer","Operable Breast Cancer",[27,28,29],"breast cancer","Mastectomy","Pre-pectoral reconstruction","NOT_YET_RECRUITING","2026-05-11",{"date":33,"type":34},"2026-05-18","ACTUAL",{"date":36,"type":20},"2026-06",{"date":38,"type":20},"2027-12",{"name":40,"class":41},"IRCCS San Raffaele","OTHER",""]