[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"opioid-use-after-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:opioid-use-after-surgery":95},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,83],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100053401",false,"NCT07296770","An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service","TPS-Select","Patients may take part in this study if they:\n\n* Are 18 years or older\n* Are having a planned (elective) surgery at UCSF\n* Are identified as higher risk for chronic pain after surgery by a computer model\n* Agree to join the study and sign consent\n\nPatients cannot take part if they:\n\n* Have too much missing information in their medical record (more than 75%)\n* Have a surgery scheduled less than 1 month away\n* Have serious memory or thinking problems that make participation difficult\n* Are in another clinical study that would interfere with this one\n* Do not live in California\n* Choose not to participate or sign consent\n* Have severe depression with suicidal thoughts that requires urgent care\n* Are pregnant or breastfeeding\n\nA patient who has already joined may be removed from the study if they:\n\n* Cannot complete most of the scheduled follow-up phone calls or pre-surgery recommendations (up to 6 months after discharge)\n* Pass away between the surgery booking date and 6 months after leaving the hospital\n* Become pregnant in the 6 months after discharge\n\nPatients may remain enrolled but their data may not be used in the main study results if they experience:\n\n* A long-lasting infection after surgery\n* Hardware problems related to their surgery (for example, issues with implanted devices)\n* A major injury or life event that affects their pain levels, such as a significant fall or an emergency surgery\n* Difficulty completing the planned follow-up phone calls up to 6 months after discharge","ALL","18 Years",{"count":18,"type":19},126,"ESTIMATED","INTERVENTIONAL",[22],"PHASE3","The goal of this clinical trial is to learn whether a pain-management program called a Transitional Pain Service can help prevent long-term pain and reduce opioid needs after surgery in adult surgical patients who may be at higher risk for developing persistent pain. The main questions this trial aims to answer are: 1) Does the Transitional Pain Service help high-risk surgical patients manage pain better after surgery? 2) Can a computer tool (an algorithm) improve screening of patients for long-lasting pain after surgery? The investigators will compare patients who continue with their usual care to patients who receive support from the Transitional Pain Service to see if the program leads to better pain control and lower opioid use. Participants will share information about their pain levels and the pain-relief treatments they are using before and after surgery so researchers can better understand how the program affects recovery. Patients assigned to the Transitional Pain Service will also be offered additional coordinated support before and after their surgery to help optimize their pain control and overall recovery.",[25,26,27],"Postsurgical Pain Management","Postsurgical Pain, Chronic","Opioid Use After Surgery",[29,30,31,32],"Pain","Transitional Pain Service","Postsurgical Pain","Postoperative Opioid Use","NOT_YET_RECRUITING","2026-07-09",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":19},"2026-10-01",{"date":41,"type":19},"2028-07-01",{"name":43,"class":44},"University of California, San Francisco","OTHER",1,{"id":47,"slug":4,"hasResults":10,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":20,"phases":55,"briefSummary":57,"conditions":58,"keywords":67,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":45},"100630348","NCT07486505","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance (MIRROR): Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","MIRROR","The inclusion criteria are:\n\n1. Adults 18 years of age or older; and\n2. Presenting to the hospital with an open or closed appendicular fracture requiring internal fixation. Patients with multiple fractures may be included.\n\nThe exclusion criteria are:\n\n1. Does not have the English-language skills required to participate in trial interventions (in the judgement of site research personnel);\n2. Cognitive impairment (including traumatic brain injury);\n3. Auditory or visual impairment that would inhibit ability to receive intervention;\n4. Current incarceration;\n5. Concomitant injury which, in the opinion of the attending surgeon, is likely to impair function for as long as or longer than the patient's extremity fracture;\n6. Previously completed a standardized mindfulness program (e.g., MBSR) or regularly (e.g., daily) practice mindfulness;\n7. Active psychosis;\n8. Active suicidality;\n9. Stress fracture;\n10. Fragility fracture;\n11. Currently enrolled in a study that does not permit co-enrolment in other trials;\n12. Not willing to participate in the intervention;\n13. No provision of informed consent; or\n14. Other reason as approved by the Data Coordinating Centre.",{"count":54,"type":19},50,[56],"NA","Breaking a bone is not only physically painful but also emotionally overwhelming. Patients often experience intense pain, anxiety, and uncertainty as they are rushed to hospital, undergo emergency treatment, and prepare for surgery. After surgery, many continue to struggle with pain and rely on opioid medications, which carry serious risks including addiction. In the context of our current opioid epidemic, it's critical that alternative treatment strategies are urgently evaluated.\n\nMindfulness is a practice that helps people focus on the present and has been shown to reduce stress and pain in other settings. In this trial, patients with broken arms or legs who need surgery at Hamilton General Hospital will be randomly assigned to one of two groups who will listen to a two-part, audio recording before and after surgery. Those in the interventional group will engage in a 7-minute audio-guided mindfulness exercise before surgery to help reduce anxiety, and another 7-minute audio-guided mindfulness exercise after surgery to help manage pain. Those in the control group will listen to a 7-minute educational audio recording before surgery and again after surgery.\n\nThe main goal is to see if this approach is practical-can enough patients be recruited, and will they complete the audio recordings? The study will also look at early signs of whether the intervention helps reduce pain, anxiety, and opioid use six weeks after surgery. If feasible, a larger study can be conducted to determine if these exercises can help patients manage pain and reduce their need for opioids after surgery.\n\nIf successful, this simple, low-cost approach could be widely used in hospitals to support recovery and reduce reliance on pain medications.",[59,60,61,62,63,64,65,66,27],"Orthopaedic Fractures","Orthopaedic Trauma Fractures and Non-unions","Orthopaedic Trauma","Orthopaedic Surgery","Orthopaedic Related Pain (Musculoskeletal Pain)","Anxiety Acute","Anxiety After Surgery","Opioid Use",[68,69,70,71,72,73],"fractures","mindfulness","pain management","fracture surgery","opioid use","anxiety","2026-04-06",{"date":76,"type":37},"2026-04-07",{"date":78,"type":19},"2026-05-01",{"date":80,"type":19},"2026-10-30",{"name":82,"class":44},"McMaster University",{"id":84,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":20,"phases":86,"briefSummary":23,"conditions":87,"keywords":88,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":93,"leadSponsor":94,"locationsCount":45},"100615758",{"count":18,"type":19},[22],[25,26,27],[29,30,31,32],"2025-12-18",{"date":91,"type":37},"2025-12-22",{"date":78,"type":19},{"date":41,"type":19},{"name":43,"class":44},""]