[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"optimal-volume-of-liposomal-bupivacaine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:optimal-volume-of-liposomal-bupivacaine":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100588537",false,"NCT06942689","Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery","Determination of the Optimal Volume of Liposomal Bupivacaine in Single-Shot Adductor Canal Block for Knee Joint Surgery-A Phase I\u002FII Trial","Inclusion Criteria:\n\n* Patients undergoing elective general anesthesia for unilateral knee joint surgery.\n* Patients who provide informed consent.\n* Aged between 18 and 65 years old, regardless of gender.\n* American Society of Anesthesiologists (ASA) physical status classification of Ⅰ to Ⅲ\n* Body mass index (BMI) ≤ 35 kg\u002Fm².\n\nExclusion Criteria:\n\n* Femoral neuropathy.\n* Coagulation dysfunction.\n* Allergy to local anesthetics.\n* Infection at the puncture site.\n* History of chronic pain or opioid use.\n* Pregnancy.\n* Diabetes mellitus and peripheral neuropathy.","ALL","18 Years","85 Years",{"count":19,"type":20},63,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB. Utilizing advanced statistical models (BOIN\u002FBOP2 design), we aim to systematically evaluate the volume-effect relationship of liposomal bupivacaine, providing precise dosing recommendations to advance personalized and optimized analgesic protocols for knee surgery.",[26],"Optimal Volume of Liposomal Bupivacaine",[28,29,30,31,32],"Liposomal Bupivacaine","Adductor Canal Block","Knee Surgery","Maximum Tolerated Volume","Quadriceps Muscle Strength","RECRUITING","2025-08-31",{"date":36,"type":37},"2025-09-08","ACTUAL",{"date":39,"type":37},"2025-06-01",{"date":41,"type":20},"2027-12-31",{"name":43,"class":44},"Nanjing First Hospital, Nanjing Medical University","OTHER",""]