[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthodontic-aligners\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthodontic-aligners":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100639840",false,"NCT07617571","Bone Metabolism in Patients Treated With 3d Printed Aligners Versus Thermoformed Aligners","Bone Metabolism in Patients Treated With 3d Printed Aligners Versus Thermoformed Aligners (Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* Minor malocclusion (2 to 4 mm of crowding) .\n* Patients in need for Antero-posterior expansion and labial tipping of incisors without interproximal reduction\n* No use of anti-inflammatory drugs or antibiotics in the past 6 months.\n* Periodontal parameters of gingival index \\\u003C1 and no pocketing with a generalized pocketing depth of \\\u003C3mm.\n* Radiographic parameters of no crestal bone loss.\n* No history of smoking.\n\nExclusion Criteria:\n\n* Signs of inflammation of the gingiva, and periodontitis.\n* Systemic conditions (kidney disease, HIV, and liver disease).\n* Teeth missing or poor oral hygiene.\n* Bone disease e.g.; osteoporosis.","ALL","18 Years","25 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","Background: Orthodontic forces induce tissue reactions by triggering perturbations from orthodontic appliances, which lead to the modelling and remodelling of alveolar bone. Despite the growing popularity of 3D-printed aligners, no studies have compared their effects on bone metabolism in comparison with thermoformed aligners. Aim: This study aims to assess bone metabolism in patients undergoing treatment with 3D-printed aligners versus thermoformed aligners.",[26,27],"Bone Metabolism","Orthodontic Aligners","NOT_YET_RECRUITING","2026-05-24",{"date":31,"type":32},"2026-06-01","ACTUAL",{"date":31,"type":20},{"date":35,"type":20},"2026-07-01",{"name":37,"class":38},"Alexandria University","OTHER",""]