[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"orthopedic-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:orthopedic-disorder":525},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,45,70,99,131,158,191,214,235,255,277,306,332,357,386,407,432,458,479],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100474701",false,"NCT05461326","Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT","All Soft Tissue Quadriceps Tendon Autograft Versus Patellar Tendon Autograft in Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Skeletally mature patients younger 65\n* ACL insufficiency\n* Scheduled to undergo autograft ACL reconstruction\n* Appropriate candidate for autograft harvest\n\nExclusion Criteria:\n\n* \\\u003C14 or 65\\>\n* Poor autograft candidate (poor tissue quality)\n* Multi ligamentous reconstruction (PCL, MCL, or PLC)\n* Pregnant or nursing\n* High likelihood of remaining non-compliant with physical therapy regimen\n* Desire to return to sport prior to 6 months\n* Inability to read and write English","ALL","14 Years","65 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","The choice of autograft for ACL reconstruction continues to be debated. To date, there has only be one completed randomized controlled trial with quad tendon to BTB and the tendon included a bone plug. There has been no study to date comparing an all soft tissue quad tendon to patellar tendon in a randomized controlled trial for ACL reconstruction.",[26,27],"Orthopedic Disorder","Anterior Cruciate Ligament Injuries",[29,30,31],"quadriceps tendon","bone tendon bone","autograft","RECRUITING","2026-06-07",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":36},"2023-09-26",{"date":40,"type":20},"2030-06-30",{"name":42,"class":43},"University of Alabama at Birmingham","OTHER",1,{"id":46,"slug":4,"hasResults":10,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":10,"sex":15,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":44},"100582901","NCT06869343","Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture","A Randomized Controlled Trial of Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture","Inclusion Criteria:\n\n* aged 50-85 undergo reverse Total Shoulder Arthroplasty by a single surgeon for proximal humerus fractures\n\nExclusion Criteria:\n\n* previous rTSA to ipsilateral shoulder\n* undergoing elective rTSA\n* Prisoners\n* unwilling to be randomized\n* unwilling or unable to attend follow up visits","50 Years","85 Years",{"count":54,"type":20},10,[23],"Proximal humerus fractures can be a debilitating injury in the elderly, impacting the ability to function independently or complete activities of daily living due to pain and restricted shoulder motion. Evidence has shown that reverse total shoulder arthroplasty (rTSA) is an effective option to improve pain and function for patients with acute displaced proximal humerus fractures. Given that patients undergoing rTSA for proximal humerus fractures typically experience worse functional outcomes, worse patient-reported outcomes, and higher rates of complication compared to those with elective indications for surgical intervention, it is critical to determine a secure path to recovery for these patients after surgery. Early rehabilitation has been proposed to be safe and effective for patients who undergo rTSA for elective indications; however, there is a paucity of research evaluating safety and effectiveness of timing of rehabilitation for rTSA patients in the trauma setting. Currently, there exists a great variability in postoperative rehabilitation protocols across orthopaedic practices. This study's objective is to determine the safety and effectiveness of early postoperative rehabilitation on the outcomes and postoperative complications of patients undergoing rTSA for proximal humerus fractures in order to provide more specific recommendations for this patient population.",[26,58,59,60],"Humerus Fracture","Shoulder Arthroplasty","Reverse Shoulder Replacement","2026-06-05",{"date":63,"type":36},"2026-06-09",{"date":65,"type":36},"2025-05-19",{"date":67,"type":20},"2026-12-31",{"name":69,"class":43},"University of Virginia",{"id":71,"slug":4,"hasResults":10,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":44},"100468594","NCT05381818","Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery","Preoperative Inspiratory Muscle Strength Training and Pulmonary Complications After Surgery","Inclusion Criteria:\n\n* 18 or older\n* History of current or previous tobacco use (including vaping containing nicotine products)\n* One or more risk factors for post operative pulmonary complications including history of current or previous tobacco use, a clinically diagnosed lung disease, shortness of breath with minimal exertion, FEV1 or FVC less than 80% than predicted or respiratory muscles strength below lower limit of normal for age and sex.\n* History of smoking related lung disease\n* Projected surgical time \\> 30 minutes\n* Ability to follow instructions to complete IMT exercises\n* Ability to communicate adverse effects such as pain or fatigue or the need for assistance\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists physical status classification of 4 or greater .\n* Recent history of acute pneumonia or lower respiratory infection in the previous two weeks requiring acute corticosteroid or antibiotic medication,\n* Preoperative dependence on continuous supplemental oxygen dependence.\n* Preoperative dependence on positive pressure breathing support while awake and upright (night time CPAP permitted),\n* Diagnosis of a neurologic condition (i.e. MS, ALS, Parkinson's, stroke),\n* Participating in a pulmonary rehabilitation program\n* Severe obstructive pulmonary disease (Classification of Global Initiative for Chronic Obstructive Lung Disease (GOLD) 3 or higher, indicating FEV1\\\u003C50% predicted.\n* Patients with an infectious disease requiring isolation (i.e. COVID-19).","18 Years","100 Years",{"count":79,"type":20},36,[23],"The purpose of this research study is to evaluate effects of respiratory strengthening exercises on breathing function, in people who have orthopedic surgery. It is known that breathing function decreases for a few days after surgery. in In this study, we want to see if exercising before surgery strengthens the breathing muscles and improves recovery after surgery.",[83,84,85,26],"Arthropathy of Knee","Arthropathy of Hip","Lower Extremity Fracture",[87,88,89],"Inspiratory muscle training","Pulmonary complications","Total joint replacement","2026-05-13",{"date":92,"type":36},"2026-05-15",{"date":94,"type":36},"2022-07-01",{"date":96,"type":20},"2026-12",{"name":98,"class":43},"University of Florida",{"id":100,"slug":4,"hasResults":10,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":108,"conditions":109,"keywords":113,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":44},"100592267","NCT06991205","Web-based Mind-body Program to Improve Resilience Among Risky Substance Users With Persistent Upper Extremity Pain","Feasibility RCT of Web-based Mind-body Treatment to Enhance Resilience Among Patients With Painful Nontraumatic Upper-extremity Conditions and Commorbid Risky Substance Use","Inclusion Criteria:\n\n1. Outpatient adults seeking care in the Hand and Arm Center\n2. Diagnosed with a non-traumatic painful upper-extremity condition (NPUC)\n3. Pain score \\> 4 on the Numerical Rating Scale (NRS)\n4. Risky substance use (scores \\>10 and \\\u003C27 for alcohol, and \\>3 and \\\u003C27 for cannabis, cocaine, amphetamine-type stimulants, inhalants, sedatives, hallucinogens, opioids, tobacco products, and e-cigarette on The World Health Organization's - Alcohol, Smoking and Substance Involvement Screening Test \\[WHO-ASSIST\\])\n5. Owns a smartphone, laptop, or computer with internet access\n6. Age ≥18yr\n7. English fluency\n8. Ability and willingness to participate in a live video focus group and the following asynchronous Web-based intervention\n\nExclusion Criteria:\n\n1. Participation in mind-body or specialized substance abuse treatment in the past 3 months\n2. Practice of mindfulness \\>45 minutes\u002Fweek in the past 3 months\n3. Psychotropic medications (e.g. antidepressants) changed in the past 3 months\n4. Serious untreated mental illness (e.g., Schizophrenia)\n5. Suicidal ideation with intent or plan\n6. Pregnancy\n7. Secondary gains that may bias motivation (e.g., pending disability claim),\n8. Moderate to severe cognitive impairment (score ≥4 on the Short Portable Mental Status Questionnaire (SPMSQ))\n9. History of surgery for the presented NPUC within the past 6 months OR future plans for surgery.",{"count":106,"type":20},50,[23],"The investigator aims to conduct a feasibility randomized controlled trial (RCT) (N=50) to test the feasibility, acceptability, and credibility of an asynchronous web-based mind-body intervention (Toolkit for Resilient Life beyond Pain and Substance Use; Web-TIRELESS) versus web-based minimally enhanced usual care (Web-MEUC) among adult patients with a painful non-traumatic upper-extremity condition(s) (PNUC) and commorbid risky substance use.\n\nDeliverables: \\[1\\] Adapt and refine open pilot protocol, patient recruitment, and other study materials. \\[2\\] Assess the feasibility, acceptability, and credibility of Web-TIRELESS and Web-MEUC in preparation for future research.",[26,110,111,112],"Nontraumatic Injury","Upper Extremity Pain","Risky Substance Use",[114,115,116,117,118,119,120,121],"Upper Extremity Problem","Risky substance use","Randomized Controlled Trial (RCT)","Mindfulness","Nontraumatic conditions","Chronic pain","Psychiatry","Feasibility","2026-03-11",{"date":124,"type":36},"2026-03-13",{"date":126,"type":36},"2025-09-15",{"date":128,"type":20},"2027-03-01",{"name":130,"class":43},"Jafar Bakhshaie",{"id":132,"slug":4,"hasResults":10,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":138,"sex":15,"minAge":76,"maxAge":77,"enrollmentInfo":139,"targetDuration":141,"studyType":142,"phases":4,"briefSummary":143,"conditions":144,"keywords":145,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":157},"100551430","NCT06459986","The Duration of Spinal Anaesthesia - a Prospective, Observational Cohort Study","The Duration of Spinal Anaesthesia - a Prospective Observational Cohort Study","Spinalrocks","Inclusion Criteria:\n\n* Scheduled for elective orthopaedic surgical procedures performed in spinal anaesthesia\n* ASA 1-4.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Anticoagulant medication therapy not paused according ESAIC\u002FESRA 2022 guidelines\n* Local infection at the lumbar puncture site\n* Bleeding disorder\n* Unable to cooperate with the spinal anaesthesia procedure.",true,{"count":140,"type":20},2000,"1 Day","OBSERVATIONAL","Today, surgery in an ambulatory setting is preferred for many reasons. Total hip and knee arthroplasty (THA and TKA) are now procedures where patients can be sent home on the same day of the surgical procedure. However, this requires substantial knowledge of factors affecting the length of hospital stay. In this prospective, observational cohort study, we will investigate factors that affect the duration of spinal anaesthesia which is often used in THA and TKA. The aim is to gather enough data to be able to determine how local anaesthetic volume and dose affect the duration of spinal anaesthesia. This will enable us to decide whether spinal anaesthesia is a good option when performing TKA and THA in an ambulatory setting.",[26],[146,147],"Regional anaesthesia","Spinal anaesthesia","2026-01-15",{"date":150,"type":36},"2026-01-20",{"date":152,"type":36},"2024-06-03",{"date":154,"type":20},"2026-12-01",{"name":156,"class":43},"Nordsjaellands Hospital",2,{"id":159,"slug":4,"hasResults":10,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":138,"sex":15,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":169,"studyType":142,"phases":4,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":44},"100467071","NCT05361980","Pediatric Orthopaedic Implant Safety & Efficacy","Global Pediatric Orthopaedic Implant Safety & Efficacy Clinical Follow-up Program","Global POISE","Inclusion Criteria:\n\n* Patients indicated for the device-specific indication, per physician discretion and as indicated in the device IFU. Off-label use is strongly discouraged; however, any and all on- and off-label indications for use of the products in this program will be collected and stratified accordingly\n* Patients must be able to adhere to the required length of follow-up for the endpoints of each individual product\n* Informed consent\u002Fassent is required\n\nExclusion Criteria:\n\n* Patients with a demonstrated sensitivity to metals\n* Patients with an inability to follow a post-operative regimen","0 Years","25 Years",{"count":168,"type":20},4000,"2 Years","Implant devices are important tools - their use is essential across a number of orthopaedic indications, including hip conditions, trauma and limb deformity.\n\nGiven the vital role fixation devices play in maintaining alignment, promoting healthy bone healing and preventing joint degeneration, it is essential to understand the expected lifetime outcomes of these implants, and evaluate their safety and efficacy.\n\nProspective implant efficacy and safety registries are needed to support this endeavour, especially considering new regulatory requirements from the European Union Medical Devices Regulation (EU MDR) in relation to post-market clinical follow-up (PMCF).",[172,173,26,174,175,176,177,178,179,180,181],"Fracture","Lengthening; Leg","Deformity of Limb","Deformity; Bone","Implant Breakage","Implant Complication","Hip Dysplasia","Pediatric ALL","Hip Disease","Hip Dislocation","2025-11-19",{"date":184,"type":36},"2025-11-24",{"date":186,"type":36},"2022-01-06",{"date":188,"type":20},"2029-12",{"name":190,"class":43},"University of British Columbia",{"id":192,"slug":4,"hasResults":10,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":10,"sex":15,"minAge":197,"maxAge":76,"enrollmentInfo":198,"targetDuration":4,"studyType":21,"phases":200,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":44},"100424777","NCT04811313","Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and\u002For Acetabular Osteotomy","Impact of Tranexamic Acid Use on Blood Loss and Transfusion Rates After Hip Reconstruction in Children, A Randomized Controlled Trial","Inclusion Criteria:\n\n* ASA I - II\n* Scheduled for acetabular osteotomy and\u002For proximal femoral derotation osteotomies.\n\nExclusion Criteria:\n\n* Patient's guardian refusal to participate in the study.\n* Children known to have pre-existing bleeding or coagulation disorders.\n* Children with anemia; defined according to (WHO ) cutoffs as Hb level\\\u003C11g\u002Fdl for girls and \\\u003C12g\u002Fdl for boys\n* History of epilepsy.\n* History of renal insufficiency or failure","1 Year",{"count":199,"type":20},400,[23],"Surgical hip reconstruction reduces the hip joint through soft tissue releases and osteotomies of the femur and\u002For pelvis. Blood loss and subsequent blood transfusion are normal consequences of hip reconstruction.",[203,204,26],"Intraoperative Blood Loss","Pediatric","2025-11-14",{"date":207,"type":36},"2025-11-17",{"date":209,"type":36},"2025-04-03",{"date":211,"type":20},"2026-03",{"name":213,"class":43},"Assiut University",{"id":215,"slug":4,"hasResults":10,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":4,"enrollmentInfo":219,"targetDuration":221,"studyType":142,"phases":4,"briefSummary":222,"conditions":223,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":234},"100381311","NCT04244942","CERAMENT™| Bone Void Filler Device Registry","Inclusion Criteria:\n\n* 18 years and over (on the day of surgery)\n* Receive CERAMENT BVF as a component of their treatment at a participating, contracted center or healthcare provider, in accordance with the IFU for the implanted product\n* In receipt of patient information leaflet and have signed appropriately designed informed consent\n\nExclusion Criteria:\n\n* Any exclusion criteria as per IFU for CERAMENT BVF\n* Any off-label use",{"count":220,"type":20},300,"18 Months","A device registry to compile data on the performance of CERAMENT BONE VOID FILLER in normal use.",[26],"2025-09-24",{"date":226,"type":36},"2025-09-29",{"date":228,"type":36},"2020-03-30",{"date":230,"type":20},"2028-03-30",{"name":232,"class":233},"BONESUPPORT AB","INDUSTRY",13,{"id":236,"slug":4,"hasResults":10,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":244,"conditions":245,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":44},"100605884","NCT07168330","Clinical and Radiological Evaluation of Total Ankle Replacement (ProtesiTT)","Clinical and Radiological Evaluation in Patients With Total Ankle Replacement","ProtesiTT","Inclusion Criteria:\n\n* patients treated with ankle replacement for osteoarthritis\n* The patient is willing and able to complete scheduled follow-up evaluations questionnaires and radiographic examination as described in the Informed Consent\n\nExclusion Criteria:\n\n* patients without radiographic follow-up","90 Years",{"count":19,"type":20},"Numerous studies reported the efficacy of new third-generation of total ankle arthroplasties for the treatment of advanced ankle osteoarthritis and clinical results are comparable to ankle arthrodesis. The improvement in knowledge of ankle joint biomechanics, instrumentation, surgical approach may led to even higher clinical results in comparison to arthrodesis.\n\nMany of the studies reporting the results of ankle replacement are provided by surgeons involved at least in the initial design of the implant. Thus, familiarity with the system can be a potential bias affecting outcomes and orthopedic surgeons may find difficulties in reproducing the results.\n\nIn this study, we will assess the clinical and radiological outcomes in patients who underwent this procedure performed by non-designer surgeons",[26],"2025-09-11",{"date":248,"type":36},"2025-09-17",{"date":250,"type":36},"2017-07-01",{"date":252,"type":20},"2027-12-31",{"name":254,"class":43},"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio",{"id":256,"slug":4,"hasResults":10,"nctId":257,"briefTitle":258,"officialTitle":258,"acronym":259,"eligibilityCriteria":260,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":4,"enrollmentInfo":261,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":263,"conditions":264,"keywords":265,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":44},"100516245","NCT06002009","SupraScapular Cuff Study: Assessing the Effects of Size and Type of Rotator Cuff Tear on Suprascapular Nerve Function","SSCuFF","Inclusion Criteria:\n\n• All patients age ≥18 years presenting to a UHNM shoulder clinic with a confirmed diagnosis of a rotator cuff tear (affecting one or both shoulders).\n\nExclusion Criteria:\n\n* Bony pathology (such as significant shoulder arthritis that would exclude isolated rotator cuff repair)\n* Grossly abnormal shoulder anatomy\n* Motor Neurone Disease\n* Cervical cord disease affecting the SSN nerve roots\n* Patients unable to undergo MRI scan\n* Previous surgery at the affected glenohumeral joint\n* Patients unable to tolerate NCS\n* Acute fracture affecting the glenohumeral joint\n* Recent glenohumeral joint dislocation (past 12 months)\n* Patients unable or unwilling to give full informed consent\n* Patients unable or unwilling to comply with the study procedures",{"count":262,"type":20},250,"The primary objective of the study is to determine in adult patients with a rotator cuff tear, what size and pattern of rotator cuff tear would result in damage to the suprascapular nerve.\n\nThe secondary objectives are\n\n1. To determine if an injured suprascapular nerve can recover if the rotator cuff tear is surgically repaired.\n2. To determine if there is a limit of retraction before the suprascapular nerve is irreversibly damaged.\n3. To determine factors that are protective against SSN injury.\n4. Can the patient data gathered be used to optimise operative procedures.",[26],[266,267],"Rotator cuff tear","Suprascapular nerve function","2025-08-26",{"date":270,"type":36},"2025-09-03",{"date":272,"type":36},"2025-06-23",{"date":274,"type":20},"2029-09-30",{"name":276,"class":43},"University Hospitals of North Midlands NHS Trust",{"id":278,"slug":4,"hasResults":10,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":138,"sex":15,"minAge":76,"maxAge":52,"enrollmentInfo":283,"targetDuration":4,"studyType":21,"phases":285,"briefSummary":286,"conditions":287,"keywords":289,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":44},"100480341","NCT05534724","A Study to Compare Early and Partial Weight-bearing After Hallux Valgus Surgery","Is Full Weight Bearing After the Modified Lapidus Operation Possible? A Randomized Controlled Trial to Compare Early and Partial Weight-bearing","Inclusion Criteria:\n\n* Patient who undergo modified Lapidus arthrodesis operation and associated with:\n* Additional surgical gestures such as e.g. interventions on the proximal phalanx of the first finger (Akin) or interventions on the 2nd and \u002F or 3rd ray (Weil \u002F Hohmann) \\[23,24\\].\n* Willingness and ability to participate in the trial\n* Signed Informed Consent\n\nExclusion Criteria:\n\n* Diabetes mellitus\n* Rheumatoid arthritis\n* Previous foot surgery\n* Classic Lapidus surgery\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, general physical problem of the participant, etc.\n* Inability or contraindications to undergo the investigated intervention\n* Pregnant women",{"count":284,"type":20},122,[23],"This is a two-arm randomized controlled trial with the aim to evaluate the effectiveness and safety of post-operative management after a modified Lapidus arthrodesis with\u002Fwithout an Akin or a Weil\u002FHohmann surgery fusion with immediate complete weight-bearing compared with partial weight-bearing (10 - 15kg) for 6 weeks as a novel approach for rehabilitation after a foot surgery.",[288,26],"Hallux Valgus",[290,291,292,293,294,295,296],"Quality of life","Bone consolidation","Foot surgery","Lapidus surgery","Weil surgery","Hohmann surgery","Akin surgery","2025-08-05",{"date":299,"type":36},"2025-08-06",{"date":301,"type":36},"2023-01-19",{"date":303,"type":20},"2026-07-01",{"name":305,"class":43},"Ente Ospedaliero Cantonale, Bellinzona",{"id":307,"slug":4,"hasResults":10,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":21,"phases":314,"briefSummary":315,"conditions":316,"keywords":318,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":44},"100583496","NCT06877078","Effect of Pre-Surgery Constipation Podcast: A RCT","The Effect of Information About Constipation Via a Podcast for Patients Prior to Planned Orthopaedic Surgery - a Randomised Controlled Trial.","Inclusion Criteria:\n\n* Is 18 years or older.\n* Has a scheduled back, shoulder, knee, or hip operation at the Elective Surgery Centre\n* Is able to read, speak and understand Danish.\n* Has an email address and gives consent to contact via email\n* Has access to and is able to navigate a computer, tablet or smartphone\n\nExclusion Criteria:\n\n* Is unable to listen to the podcast, due to severe hearing loss.\n* Is affected by cognitive dysfunction or mental illness that makes participation difficult.\n* Is participating in other trials at the Elective Surgery Centre.\n* Is diagnosed with a gastrointestinal condition, this being Crohns, Colitis ulcerosa, or celiac disease.\n* Has previously received a colostomy or ileostomy.",{"count":313,"type":20},600,[23],"In this study, the investigators will evaluate the effect of a podcast on constipation on the number of patients with constipation. It is hypothesised that the podcast on constipation, will prevent constipation in the period leading up to and after surgery.\n\nThis is a randomised controlled trial. The population of the study will consist of patients with planned orthopaedic surgery (knee, hip, shoulder, and back) at the Elective Surgery Centre, Silkeborg Regional Hospital. The sample of the study will consist of patients 18 years or older, who are able to understand, read and write Danish, has an email address, has access to and is able to navigate a computer, tablet or smartphone, does not have severe hearing loss, does not have cognitive dysfunction or other mental illness that would make participation difficult, is not participating in other trials at the Elective Surgery Centre, is not diagnosed with a gastrointestinal condition (Crohns, Colitis ulcerosa or celiac disease), and does not previously have received a colostomy or ileostomy.\n\nPatients will be randomised to either a control group or an intervention group. Both groups will receive the standard information at the preoperative consultation and after randomisation. The intervention group will also receive a podcast.\n\nThe study will collect data using an online questionnaire, that includes The ROME IV Diagnostic Criteria for functional constipation and \"The Patient Assessment of Constipation Quality of Life (PAC-QOL)\". Data will be collected at 4 times: (1) after the preoperative consultation (baseline), (2) 1-2 days prior to surgery, (3) 1 week after surgery, and (4) 4 weeks after surgery.",[317,26],"Constipation",[319,320,321,322],"podcast","patient information","constipation","orthopedic surgery","2025-05-07",{"date":325,"type":36},"2025-05-08",{"date":327,"type":36},"2025-04-01",{"date":329,"type":20},"2027-12-01",{"name":331,"class":43},"Central Jutland Regional Hospital",{"id":333,"slug":4,"hasResults":10,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":21,"phases":341,"briefSummary":342,"conditions":343,"keywords":345,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":44},"100560626","NCT06579599","Study on the Preventive Effect of Establishing an Integrated Working Group of Doctors and Nurses in Operating Room","Study on the Preventive Effect of Establishing an Integrated Working Group of Doctors and Nurses in Operating Room on Incision Infection in Orthopedic Surgery and Its Clinical Enlightenment","Inclusion Criteria:\n\n* (1) All selected cases met the relevant diagnostic criteria outlined in the orthopedic disease guidelines. Diagnosis was confirmed through imaging methods.\n\n  (2) The patients ranged in age from 18 to 70. (3) All individuals underwent surgery in the orthopedic department of our hospital.\n\n  (4) The vital signs of the patients were essentially stable. (5) Patients possessed normal cognitive function before the operation and demonstrated the ability to listen, speak, read, and write.\n\nExclusion Criteria:\n\n* (1) Orthopedic patients with multiple injuries in other locations (such as craniocerebral trauma, chest trauma, etc.); (2) Patients with severe internal diseases, such as severe anemia, severe diabetes, liver insufficiency; (3) Patients with chronic infectious diseases; (4) Patients with malignant tumor; (5) Patients with pathological fracture, such as bone tumor; (6) Patients with mental diseases and cognitive impairment.","70 Years",{"count":340,"type":20},130,[23],"To explore the preventive effect and clinical enlightenment of establishing an integrated working group of doctors and nurses in operating room on incision infection in orthopedic surgery.",[26,344],"Incision Infection",[26,344,346,347],"Operating room","Integration of medical staff","2025-02-16",{"date":350,"type":36},"2025-02-19",{"date":352,"type":36},"2024-12-30",{"date":354,"type":20},"2025-12-30",{"name":356,"class":43},"The Fourth Affiliated Hospital of Zhejiang University School of Medicine",{"id":358,"slug":4,"hasResults":10,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":52,"enrollmentInfo":363,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":364,"conditions":365,"keywords":368,"overallStatus":376,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":4},"100541205","NCT06326827","In'Oss™ (MBCP® Putty) Ortho","Study of the Osteoconductive Potential of the Injectable Bone Substitute In'Oss™ (MBCP® Putty) in the Filling of Orthopaedic Bone Defects","Inclusion Criteria:\n\n1. Patient is male or female, 18 - 85 years old;\n2. Patient is willing and able to give written informed consent;\n3. Patient is able to comply with a prior medical examination;\n4. Patient is or has been scheduled for a surgical procedure to correct epiphyso-metaphyseal and\u002For metaphyso-diaphyseal bone defect in one of the following anatomical locations:\n\n   * Proximal humerus ▪ Distal radius\n   * Distal femur ▪ Proximal tibia ▪ Distal tibia\n5. Patient is willing and able to comply with the study procedures during surgery and the post-surgical follow up period, up to 12 months.\n\nExclusion Criteria:\n\n1. Patient has had an infection in the same extremity within last 24 months;\n2. Patient has signs of necrosis at the surgical site;\n3. Patient has cellulitis;\n4. Patient has granuloma or non-curetted cyst;\n5. Patient has an history of uncontrolled diabetes;\n6. Patient is alcoholic and\u002For heavy smoker (\\> 20 cigarettes per day);\n7. Patient has a congenital or acquired immunodeficiency;\n8. Patient has severe bone loss (≥ 40cm3);\n9. Patient is on long-term steroidal therapy or treatment acting on the calcium or phosphorus metabolism;\n10. Patient is or has been scheduled for surgery that would involve intra-articular implantation of the study device;\n11. Patient who has or had an uncontained bone defect created as a result of trauma injury or surgically created;\n12. Patient was exposed to any radiation (e.g. X-Rays, handling of radiolabelled materials) other than the normal background radiation within the 12 months before the screening visit;\n13. Patient is pregnant;\n14. Patient who is an employee at the study site;\n15. Patient is known to be non-compliant with medical treatment or follow-up\n16. Patient has any significant or unstable medical\u002Fpsychiatric condition that, in the opinion of the Investigator, would interfere with their ability to participate in the study;\n17. Patient is currently enrolled or planning to enrol in another clinical study or treatment with another investigational drug\u002Fdevice that may interfere with the assessments, visits or outcomes of this study.",{"count":19,"type":20},"Study of the osteoconductive potential of the injectable bone substitute In'Oss™ (MBCP® Putty) in the filling of orthopaedic bone defects to collect Post-Market Clinical Follow-up (PMCF) data for the CE-marked In'Oss™ (MBCP® Putty) device in the orthopaedic trauma surgery",[26,366,367],"Trauma Injury","Extremity Injury",[369,370,371,372,373,172,374,375],"Proximal humerus","Distal radius","Distal femur","Proximal tibia","Distal tibia","MBCP Putty","Bone defect reconstruction","NOT_YET_RECRUITING","2025-02-03",{"date":379,"type":36},"2025-02-05",{"date":381,"type":20},"2025-03",{"date":383,"type":20},"2027-03",{"name":385,"class":233},"Advanced Medical Solutions Ltd.",{"id":387,"slug":4,"hasResults":10,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":391,"eligibilityCriteria":392,"healthyVolunteers":138,"sex":15,"minAge":197,"maxAge":242,"enrollmentInfo":393,"targetDuration":141,"studyType":142,"phases":4,"briefSummary":394,"conditions":395,"keywords":396,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":44},"100236389","NCT02355301","Improve the Quality of Care in Patients With Orthopaedic Disorders","How to Improve the Quality of Care in Patients With Orthopaedic Disorders? - by Using the ICF in All Patients After Conservative or Surgical Treatment. - Through the Creation of an International Norm to Improve the Surgical Precision","QualOrtho","Inclusion Criteria:\n\n* all patients with orthopedic disorders : muscular skeletal impairment\n\nExclusion Criteria:\n\nDementia patients with multiple disorders Patients who do not understand the instructions",{"count":140,"type":20},"The main objective of the investigators is to improve the quality of care in patients with orthopedic disorders followed in St Luc hospital (Brussels Belgium). To do this, the investigators want to assess the impact of Orthopedic treatments at the structural level (bone structure, muscle, etc.), at the functional level (mobility, strength, stiffness...), on the restriction of activities of patients (walking, make its care daily..) and on the limitation of participation in the life of every day (sport, work, social life, cultural...). This functional evaluation of patients with orthopedic disorders by the ICF model is an original approach rarely used in muscular-skeletal impairments that can very improve the management of these patients and their quality of life. In addition, the investigators associate the harvesting of all medical and computer data collected by high-precision tools in the surgical treatments, to better define the surgical precision and improve the quality of surgical care.",[26],[397],"ICF, impairment, activity, satisfaction, quality of care","2024-06-26",{"date":400,"type":36},"2024-06-27",{"date":402,"type":36},"2015-04-05",{"date":404,"type":20},"2026-10-01",{"name":406,"class":43},"Cliniques universitaires Saint-Luc- Université Catholique de Louvain",{"id":408,"slug":4,"hasResults":10,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":412,"eligibilityCriteria":413,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":414,"enrollmentInfo":415,"targetDuration":4,"studyType":21,"phases":416,"briefSummary":417,"conditions":418,"keywords":419,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":430,"locationsCount":44},"100542365","NCT06341920","BoneFit: Multimodal Prehabilitation for People Preparing for Orthopaedic Surgery","BoneFit: A Student-led Multimodal Prehabilitation Service for Orthopaedic Surgical Patients in Hull","BoneFit","Inclusion Criteria:\n\n* Waiting for unilateral total hip or knee replacement surgery for a minimum of 6 months;\n* Able to provide informed consent;\n\nExclusion Criteria:\n\n* Previous hip or knee surgery;\n* Any medical conditions for which moderate to vigorous exercise is contraindicated;\n* Patellar or hip joint instability;\n* Any other disease\u002Fcondition which severely effects functional performance e.g. stroke or Parkinson's disease;\n* Chronic depression or significant psychiatric disorder;\n* Enrolled in a clinical trial (or recently completed one);\n* Cognitive impairment which would affect compliance to BoneFIt service;\n* Patients unable or unwilling to commit to required study follow-ups\n* Pregnancy;","75 Years",{"count":106,"type":20},[23],"To conduct a pilot feasibility study to determine the effect of a student-led prehabilitation service in people awaiting total hip or knee replacement surgery.",[26],[420,421,422,423],"prehabilitation","optimisation","surgery","surgical preparation","2024-06-11",{"date":426,"type":36},"2024-06-12",{"date":428,"type":36},"2024-05-16",{"date":329,"type":20},{"name":431,"class":43},"University of Hull",{"id":433,"slug":4,"hasResults":10,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":437,"eligibilityCriteria":438,"healthyVolunteers":138,"sex":15,"minAge":439,"maxAge":76,"enrollmentInfo":440,"targetDuration":4,"studyType":21,"phases":442,"briefSummary":443,"conditions":444,"keywords":4,"overallStatus":376,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":157},"100533032","NCT06220539","CAsting and REhabilitation Versus Supervised Neglect for Osteochondral Lesions of the Talus in the Pediatric Population","CAsting and REhabilitation Versus Supervised Neglect for Osteochondral Lesions of the Talus in the Pediatric Population: The CARE Study, A Multicenter, Stratified, Block-Randomized Controlled Trial","CARE","Inclusion Criteria:\n\n* Symptomatic, osteochondral lesion of the talus\n* Diagnosed on Computed Tomography (CT)\n* Open physes of the distal tibia confirmed by a specialized musculoskeletal or pediatric radiologist\n* Age ≥4 and ≤18\n\nExclusion Criteria:\n\n* acute traumatic lesions\n* surgically treated OLTs\n* systemic diseases that can influence cartilage conditions (such as hemophilia)","4 Years",{"count":441,"type":20},76,[23],"Rationale: OCLs (osteochondral lesions) of the talus can be congenital or can occur after trauma or in patients with juvenile idiopathic arthritis (JIA). The main complaint of an OCL is pain during weightbearing activities. Therefore, these lesions have significant impact on the health status of patients.\n\nObjective: The aim of this study is to optimize the treatment for skeletally immature patients with an osteochondral lesion. The hypothesis is that a period of immobilization and supervised rehabilitation will lead to better clinical and radiological outcomes compared with standard care which is a ''skill-full'' neglect.\n\nStudy design: Observational comparative study\n\nStudy population: Skeletally immature children with an osteochondral lesion of the talus diagnosed on CT.\n\nIntervention: Patients in the intervention group will undergo an 8-week period of casting and walking on crutches. Afterwards, they will receive a protocolled period of rehabilitation under supervision of a physical therapist. The control group will have the standard care as treatment.\n\nMain study parameters\u002Fendpoints: the main study outcome is the difference between the two groups on the OxAFQ-C. Secondary study outcomes are radiologic changes in terms of morphology and lesion size, NRS during weight bearing and quality of life measured with a Peds-QL, EQ-5D-y and AAS.\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness: the burden that patients will have is mainly the time that they have to spent on fulfilling the questionnaires.",[445,26,446,447,448],"Cartilage Injury","Skeletal Injury","Rehabilitation","Physiotherapy","2024-01-13",{"date":451,"type":36},"2024-01-24",{"date":453,"type":20},"2024-02-01",{"date":455,"type":20},"2027-07-01",{"name":457,"class":43},"Tristan Buck",{"id":459,"slug":4,"hasResults":10,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":10,"sex":15,"minAge":76,"maxAge":4,"enrollmentInfo":464,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":466,"conditions":467,"keywords":468,"overallStatus":376,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":4},"100476418","NCT05483673","Analyzing Orthopedic Patient Experience Patterns in Medical Trials","A Comprehensive Study for Analyzing Orthopedic Patient Experience Patterns in Medical Trials","Inclusion Criteria:\n\n* Patient has been diagnosed with orthopedic disorder\n* Patient has self-identified as planning to enroll in an interventional clinical trial\n* Patient is 18 years old\n\nExclusion Criteria:\n\n* ECOG score of 4\n* Patient is pregnant\n* Inability to perform regular electronic reporting\n* Patient does not understand, sign, and return consent form",{"count":465,"type":20},500,"Clinical study enrollment has historically been heavily biased toward specific demographics.\n\nSeveral people will be invited to participate in this study so that it may collect a variety of data about orthopedic clinical trial experiences and identify barriers to participation as well as the causes of participants' failure or withdrawal.\n\nPeople with orthopedic disorders who are invited to take part in medical research will benefit from the analysis of the data.",[26],[469],"orthopedic","2023-12-29",{"date":472,"type":36},"2024-01-02",{"date":474,"type":20},"2024-08",{"date":476,"type":20},"2026-08",{"name":478,"class":233},"Power Life Sciences Inc.",{"id":480,"slug":4,"hasResults":10,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":4,"eligibilityCriteria":484,"healthyVolunteers":138,"sex":15,"minAge":76,"maxAge":4,"enrollmentInfo":485,"targetDuration":4,"studyType":21,"phases":487,"briefSummary":489,"conditions":490,"keywords":507,"overallStatus":376,"whyStopped":4,"lastUpdateSubmitDate":516,"lastUpdatePostDateStruct":517,"startDateStruct":519,"completionDateStruct":521,"leadSponsor":523,"locationsCount":4},"100354774","NCT03899298","Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions","Safety and Clinical Outcomes Study: Amniotic and Umbilical Cord Tissue Administration for Orthopedic, Neurologic, Urologic, Autoimmune, Renal, Cardiac and Pulmonary Conditions","Inclusion Criteria:\n\n1. Age 18 and over.\n2. Ability to attend follow up visits or at least converse on phone or complete email follow up forms.\n3. Competent to understand the study protocol and provide voluntary informed consent.\n4. Patients with any of the following conditions: Arthritis (Degenerative, Rheumatoid, Psoriatic, Lupus, Gout), Sports or Overuse Injuries (e.g. Rotator Cuff injury, Tennis Elbow), Chronic Kidney Disease (may be on dialysis), Back\u002FNeck Pain, Erectile Dysfunction, Peyronie's Disease, Alzheimer's Disease, Parkinson's Disease, Neuropathy, Post-Stroke, Post-Concussion Syndrome, COPD, Emphysema, Pulmonary Fibrosis, Post myocardial infarction (at least 6 months out), Cardiomyopathy, Congestive Heart Failure.\n\nExclusion Criteria:\n\n1. Active Cancer\n2. Pregnancy, Lactating\n3. Severe Clotting disorder\n4. Myocardial Infarction less than six months ago.",{"count":486,"type":20},5000,[488],"PHASE1","To determine the safety and efficacy of Amniotic and Umbilical Cord Tissue for the treatment of the following condition categories: Orthopedic, Neurologic, Urologic, Autoimmune, Renal, Cardiac and Pulmonary Conditions. The hypotheses are that the treatments are not only extremely safe, but also statistically beneficial for all conditions. Outcomes will be determined by numerous valid outcome instruments that compile general quality of life information along with condition-specific information as well.",[26,491,492,493,494,495,496,497,498,499,500,501,502,503,504,505,506],"Neurologic Disorder","Urologic Diseases","Erectile Dysfunction","Autoimmune Diseases","Renal Failure","Renal Insufficiency","Kidney Diseases","Cardiac Event","Cardiomyopathies","CHF","Pulmonary Disease","COPD","Alzheimer Disease","Stroke","Neuropathy;Peripheral","Arthritis",[508,509,510,511,512,513,514,515],"stem cell therapy","umbilical stem cells","amniotic stem cells","stem cells","regenerative medicine","r3 stem cell","perinatal tissue","placenta stem cell","2019-08-20",{"date":518,"type":36},"2019-08-22",{"date":520,"type":20},"2019-09-01",{"date":522,"type":20},"2029-03-20",{"name":524,"class":233},"R3 Stem Cell",""]