Osteoarthritis Ankle

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Review clinical trials related to Osteoarthritis Ankle. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Platelet Rich Plasma for Musculoskeletal Conditions

The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain levels, functional abilities, and overall patient satisfaction. This will develop a robust registry of patients treated with PRP for a range of MSK conditions. These conditions include, but are not limited to, osteoarthritis (OA) of the knee, hip, glenohumeral joint, elbow, ankle, and sacroiliac joint, as well as rotator cuff tendinopathy, lateral and medial epicondylitis, plantar fasciitis, patellar tendinopathy, Achilles tendinopathy, and proximal hamstring tendinopathy.

Participants needed: 10,000
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of UtahUpdated: May 6, 2026Locations: 1
Eligibility criteria

18+ years old [+2]

No active malignancy [+4]

Status: Recruiting

SPECT-CT vs MRI for the Diagnosis of Osteoarthritis in the Foot and Ankle

The diagnose of symptomatic osteoarthritis in the ankle, mid- and hind foot remains challenging. There is no gold standard for the work-up and various hospitals use different protocols. Current literature shows a promising role for SPECT-CT imaging in ankle, hind- and midfoot OA. In a previous study investigating the role of SPECT-CT in a reproducible group we have observed a change in diagnosis in 53% when SPECT-CT data was added to the data of conventional workup alone. In 26% of patients addition of SPECT-CT data resulted in change of the original treatment plan. To our knowledge no prospective studies are available on this subject for both SPECT-CT and MRI. In our clinic both SPECT-CT and MRI are used in the work-up for patients with ankle, hind- and midfoot pain. Although we experience good result with SPECT-CT, MRI might be able to detect symptomatic OA as well. Moreover MRI provide more information about soft tissue and is less harmful for the patient in comparison to SPECT-CT. The aim of this study is to determine the diagnostic performance of SPECT-CT and MRI when used routinely in patients with symptomatic OA of the ankle, hind- and midfoot.

Participants needed: 132
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Martini Hospital GroningenUpdated: Feb 27, 2026Locations: 1Duration: 1 Year
Eligibility criteria

Suspected symptomatic ankle, hind- or midfoot OA [+3]

Contraindication for surgery [+7]

Status: Recruiting

Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

The primary objective of this study is to study how low-impact group exercise classes affect pain scores in patients with knee, hip, and ankle pain when paired with concurrent standard of care dietitian and behavioral health consults.

Participants needed: 10,000
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of Missouri-ColumbiaUpdated: Feb 2, 2026Locations: 1
Eligibility criteria

18 and over [+3]

Pregnant [+1]