[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"overnutrition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:overnutrition":90},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100642828",false,"NCT07575932","A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)","A PHASE 2B, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE RANGING, DOSE-FINDING, UMBRELLA STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08653945 AND PF-08653944, ALONE OR IN COMBINATION, IN ADULTS WITH OVERWEIGHT OR OBESITY (SOLIS-1)","SOLIS-1","Inclusion Criteria:\n\nEligible participants for this study include:\n\n* adults aged 18 years or older with\n* obesity (BMI of 30.0 kg\u002Fm2 to 50.0 kg\u002Fm2) or with\n* overweight (BMI of 27.0 kg\u002Fm2 to \\\u003C30.0 kg\u002Fm2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.\n\nExclusion Criteria:\n\nParticipants who are not eligible include those with diabetes mellitus, a body weight change of \\>5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.","ALL","18 Years",{"count":19,"type":20},872,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).",[26,27,28,29,30,31,32,33],"Overweight","Obesity","Overweight and\u002For Obesity","Overweight or Obesity","Overnutrition","Nutrition Disorders","Nutritional and Metabolic Diseases","Body Weight",[30,31,32,33,27,26,35,36,37],"GLP-1RA","Amylin","DACRA","RECRUITING","2026-06-09",{"date":41,"type":42},"2026-06-10","ACTUAL",{"date":44,"type":42},"2026-05-11",{"date":46,"type":20},"2028-01-05",{"name":48,"class":49},"Pfizer","INDUSTRY",48,{"id":52,"slug":4,"hasResults":10,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":10,"sex":58,"minAge":59,"maxAge":17,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":64,"conditions":65,"keywords":74,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":89},"100558914","NCT06557317","In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes","Examining the Preliminary Efficacy of an In-Person Lifestyle Intervention for Black Female Adolescent\u002FCaregiver Dyads at Risk for Type 2 Diabetes Mellitus","BGW In-Person","Inclusion Criteria for adolescent participants:\n\n* 12-18 years of age\n* self-identify as Black or African American\n* have obesity (\\>=95th percentile BMI)\n\nExclusion Criteria for adolescent participants:\n\n* pregnant or within 3 months postpartum.\n* participated in a formal weight management program within 6 months prior to study.\n* currently taking medications or diagnosed with a condition known to influence metabolism, physical activity ability, or cognitive function.\n* have previously undergone bariatric surgery.\n* have type 2 diabetes.\n* unable to speak English or have developmental conditions that interfere with ability to communicate.\n\nInclusion Criteria for caregiver participants:\n\n* 18 years or older.\n* proficiency in speaking English.\n* live in the same household as the adolescent who will also be enrolled.\n* prepares the majority (\\>50%) of meals in the household.\n\nExclusion Criteria for caregiver participants:\n\n* pregnant or within 3 months postpartum.\n* unable to speak English or have developmental conditions that interfere with ability to communicate.","FEMALE","12 Years",{"count":61,"type":20},60,[63],"NA","The aim of this study is to look at changes in diabetes-related risk factors in Black adolescent girls who are at risk for type 2 diabetes and their primary female caregiver after both participating in a 12-week in-person lifestyle program.",[66,67,68,69,70,71,72,26,30,31,33,73],"Behavior, Adolescent","Childhood Obesity","Diabetes Mellitus, Type 2","Pediatric Obesity","Glucose Metabolism Disorders","Metabolic Disease","Endocrine System Diseases","Diabetes Mellitus",[75,76,77,78,27],"Adolescents","In-Person Lifestyle Program","Diabetes prevention","Black girls","2024-08-14",{"date":81,"type":42},"2024-08-16",{"date":83,"type":20},"2024-08",{"date":85,"type":20},"2024-12-31",{"name":87,"class":88},"Cornell University","OTHER",1,""]