[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"patellofemoral-pain-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:patellofemoral-pain-syndrome":607},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,43,76,108,130,155,178,197,215,233,261,287,308,327,345,370,392,417,441,463,488,507,540,564,586],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100053307",false,"NCT07698704","Popliteus Muscle Release Versus Patellofemoral Mobilization in Patellofemoral Pain Syndrome","PFPS","Inclusion Criteria:\n\n* Male and female participants aged 18-30 years.\n* minimum history of 3 months of unilateral PFP.\n* pain intensity score of ≥3 on a 10-cm Visual Analog Scale (VAS) for worst pain experienced during the previous week.\n* Pain reproduced during at least two of the following functional activities: stair ascent or descent, running, hopping, prolonged sitting, squatting, or kneeling.\n* Presence of pain on at least one of the following clinical tests: patellar compression test or palpation of the patellar facets.\n\nExclusion Criteria:\n\n* Clinical, x-ray, or MRI findings indicative of other specific pathology including osteoarthritis, meniscal, ligament or cartilage injury, apophysitis.\n* Recurrent patellar subluxation or dislocation.\n* Cortisone use over an extended period of time.\n* Previous surgery to the knee joint; trauma to the knee joint affecting the presenting clinical condition.\n* Lower limb deformities.","ALL","18 Years","30 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will be conducted to compare the effect of popliteus muscle release and patellofemoral mobilization on pain intensity, function, and quadriceps muscle strength in patients with patellofemoral pain syndrome?",[27],"Patellofemoral Pain Syndrome",[29,30,27],"Popliteus Muscle Release","Patellofemoral Mobilization","NOT_YET_RECRUITING","2026-07-07",{"date":34,"type":35},"2026-07-13","ACTUAL",{"date":37,"type":21},"2026-07-15",{"date":39,"type":21},"2026-11-01",{"name":41,"class":42},"Cairo University","OTHER",{"id":44,"slug":4,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":4,"leadSponsor":72,"locationsCount":75},"100061867","NCT00051857","MRI Study of Musculoskeletal Function","Virtual Function Anatomy (VFA)","* INCLUSION CRITERIA:\n\nAffected Participants:\n\n* Must be between the ages of 5-95 years.\n* Minors \\\u003C 18 years of age, they must be capable of providing assent (verbal or written) with parental or legal guardian permissions obtained.\n* Adults 18 \\>= years of age, they must be able to provide informed consent.\n* Have the presence of a bone, muscle, soft tissue, connective tissue injury, impairment or related muscular skeletal system pathology.\n* Ability to have an MRI Scan.\n\nHealthy Volunteer Participants\n\n* Must be between the ages of 5-95 years.\n* Minors \\\u003C 18 years of age, they must be capable of providing assent (verbal or written) with parental or legal guardian permissions obtained.\n* Adults 18 \\>= years of age, they must be able to provide informed consent.\n* Ability to have an MRI Scan.\n\nEXCLUSION CRITERIA:\n\nAffected Participants:\n\n-For the MR imaging portion of this study, all participants must complete the NIH Diagnostic Radiology screening questionnaire. If any potential contraindication is found, either the volunteer s doctor (with knowledge of the potential contraindication) or the radiology department at the NIH will be contacted to determine if the potential contraindication would exclude them from the specific MR scans being proposed.\n\nHealthy Volunteer Participants\n\n* Any relevant medical problems\n* Clinical signs of an impairment in the joint\u002Flimb being studied.\n* Any serious injury to the joint\u002Flimb being studied, previous surgery on the joint\u002Flimb being studied or extreme pain at the joint\u002Flimb being studied.\n* Neurologic Pathology affecting the muscular skeletal system\n* For the MR imaging portion of this study, all participants must complete the NIH Diagnostic Radiology screening questionnaire. If any potential contraindication is found, either the volunteer s doctor (with knowledge of the potential contraindication) or the radiology department at the NIH will be contacted to determine if the potential contraindication would exclude them from the specific MR scans being proposed.",true,"5 Years","95 Years",{"count":53,"type":21},750,"OBSERVATIONAL","This study will use magnetic resonance imaging (MRI) and ultrasound images to study how muscles, tendons, and bones work together to cause motion. The procedure is one of several tools being developed to characterize normal and impaired musculoskeletal function, with the goal of developing improved methods of diagnosis and treatment of movement disorders.\n\nHealthy normal volunteers must be age 5 to unlimited, with or without joint impairment, may be eligible for this study. Volunteers with joint impairment may not have serious injury to the joint being studied, previous surgery on the joint being studied, or extreme pain at the joint being studied.\n\nMRI uses a strong magnet and radio waves to create images of the inside of the body. The subject lies on a long narrow couch inside a metal cylinder (the scanner) for up to 3 hours while the scanner gathers data. Earplugs are worn to muffle loud noises caused by electrical switching of radiofrequency circuits used in the scanning process. A special pad or tube may be placed over or around the region being scanned to improve the quality of the data. The subject will be asked to repeatedly move a specific joint, such as the knee, for brief periods, usually less than 5 minutes. The subject can communicate via intercom with the person performing the study at all times during the procedure, and may request to stop the study at any time.\n\n...",[57,58,27],"Abnormalities","Imaging",[60,61,62,63,64,65],"Patello-Femoral","Knee","Motion","MRI","Kinematics","Natural History","RECRUITING","2026-06-27",{"date":69,"type":35},"2026-06-30",{"date":71,"type":35},"2003-03-05",{"name":73,"class":74},"National Institutes of Health Clinical Center (CC)","NIH",1,{"id":77,"slug":4,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":14,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":93,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":75},"100644562","NCT07671482","Effects of Kinesio Taping Versus McConnell Taping on Clinical Outcomes in Patients With Patellofemoral Pain Syndrome.","Effects of Kinesio Taping Versus McConnell Taping on Clinical Outcomes in Patients With Patellofemoral Pain Syndrome. A Randomized Clinical Trial.","Inclusion Criteria:\n\n* Anterior or retropatellar pain for a minimum of 3 months during functional activities.\n* 18-50 years of age.\n* Minimum pain of 3\u002F10 on the VAS score.\n* No LL physical therapy in the past 3 months.\n\nExclusion Criteria:\n\n* Meniscal or ligamentous injury\n* Neurological or systemic conditions affecting proprioception, coordination and balance.\n* Spinal referred pain or rheumatoid arthritis.\n* Hip and ankle disorders.","50 Years",{"count":84,"type":21},80,[24],"The primary goal of this randomized clinical trial (RCT) is to evaluate whether Kinesio Taping versus McConnell Taping, when integrated into a standardized hip-knee strengthening and neuromuscular control program, produces significant effects in individuals aged 18-50 with patellofemoral pain syndrome (PFPS).\n\nThe main question it aims to answer is: Does Kinesio Taping compared with McConnell Taping when both combined with a standardized hip-knee exercise program, produce different effects on quadriceps neuromuscular activation (VMO-VL sEMG), pain, functional knee pain, and dynamic knee valgus over a 6 week period intervention?\n\nParticipants will be divided into three groups for comparison: the control group will receive a structured hip-knee physical therapy exercise program without any taping intervention, Kinesio Taping group with a standardized exercise program, and a McConnell Taping group with a standardized exercise program.",[88,89,14,27,90,91,92],"Patello Femoral Pain Syndrome","Anterior Knee Pain Syndrome","Patellofemoral Disorder","Patellofemoral Pain, PFP","Patellofemoral Pain (PFPS)",[94,95,96,97,98,27,99],"Electromyography","EMG","Kinesio Taping","McConnell Taping","Exercise Therapy","Single-Leg Squat","2026-06-25",{"date":102,"type":35},"2026-06-26",{"date":104,"type":21},"2026-06",{"date":106,"type":21},"2026-10",{"name":41,"class":42},{"id":109,"slug":4,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":14,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":127,"leadSponsor":129,"locationsCount":4},"100644170","NCT07664566","Core Stability Exercises Versus Proprioceptive Training on Pain and Function in Patients With Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n* A confirmed diagnosis of Patellofemoral Pain Syndrome (PFPS) based on clinical and radiographic examination, with no evidence of other knee pathologies, as verified by an orthopaedic physician\n* Presence of unilateral PFPS for a minimum duration of three months, indicating a chronic condition\n* Age between 18 and 40 years, representing the typical symptomatic population affected by PFPS\n* Body Mass Index (BMI) less than 30 kg\u002Fm², ensuring exclusion of obesity as a confounding factor.\n* Report of increased anterior knee pain during at least two of the following patellofemoral stress-provoking activities: stair ascent or descent, squatting, kneeling, running, or prolonged sitting\n* A positive patellar grind test (Clarke's sign) confirming involvement of the patellofemoral joint\n\nExclusion Criteria:\n\n* Presence of chronic pain conditions unrelated to Patellofemoral Pain Syndrome (PFPS) as Rheumatoid arthritis, Chronic neuropathic pain, chronic low back pain and knee and hip osteoarthritis.\n* Pregnancy or history of recent trauma affecting the pelvic or knee region\n* History of corticosteroid injection in the affected knee\n* Presence of ankle arthritis or gouty arthritis, which may alter lower-limb biomechanics\n* History of previous surgical intervention involving the lumbar spine, hip, knee, or foot\n* Presence of lower-limb structural deformities, including pes planus, knee valgus, or knee varus deformities","40 Years",{"count":115,"type":21},63,[24],"This study will be conducted to investigate the effect of core stability exercises versus proprioceptive training in patients with patellofemoral pain syndrome.",[27],[120,121,27,122],"Core Stability Exercises","Proprioceptive Training","Pain and Function","2026-06-18",{"date":125,"type":35},"2026-06-24",{"date":69,"type":21},{"date":128,"type":21},"2027-03-20",{"name":41,"class":42},{"id":131,"slug":4,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":142,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":4},"100641937","NCT07655258","High-Intensity Laser Acupuncture for Treating Patellofemoral Pain Syndrome","High-Intensity Laser Acupuncture for Treating Patellofemoral Pain Syndrome: Impact on Pain, Function, and Patient Satisfaction","Inclusion Criteria:\n\n* Patients with patellofemoral pain syndrome (positive Clarkes sign and Waldron test)\n* Age from 18 to 25 years\n* Patients suffering from pain which aggravated by prolonged sitting, stair climbing, running, squatting, kneeling, hopping\\\\jumping, overuse activities and relieved by rest for at least 3 months\n* Visual analog scale (VAS) greater than 3 points in daily activity\n* The ability to participate in the study and follow the treatment schedule.\n\nExclusion Criteria:\n\n* Physiotherapy in the last 12 months\n* Intra-articular injection in the last 3 months\n* Other knee disorders such as: (osteoarthritis, previous knee surgery, history of knee arthroplasty, or traumatic injury related joint deformity)\n* BMI greater than or equal 30\n* Pregnancy\n* Pacemaker insertion\n* Photosensitivity\n* History of using oral analgesic or NSAIDs in the previous 4 weeks,\n* History of malignancy, psychiatric disorder, mental retardation, neurologic dysfunction, diabetes mellitus, or uncontrolled hypertension.","25 Years",{"count":138,"type":21},60,[24],"Patellofemoral pain syndrome (PFPS) is among the most prevalent forms of knee discomfort. The main complaint is typically anterior knee pain, which gets worse while jumping, bending knee, going up or down stairs, or sitting for long periods of time with bent knee. Teens and early adulthood are commonly affected by patellofemoral pain syndrome, with a higher frequency in females. In healthy general populations, the prevalence of patellofemoral pain syndrome is 22.7%, and in teens, it is 28.9%.",[27],[143,144,145,146],"Patellofemoral pain syndrome","high-intensity laser acupuncture","Function","patient satisfaction","2026-06-12",{"date":149,"type":35},"2026-06-17",{"date":151,"type":21},"2026-06-20",{"date":153,"type":21},"2026-08-31",{"name":41,"class":42},{"id":156,"slug":4,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":164,"conditions":165,"keywords":166,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":4},"100642872","NCT07642011","Relationship Between Knee Pain And Proprioception During Single Leg Squat In Patellofemoral Pain Syndrome","PPS","Inclusion Criteria:\n\n* Age ranges from 18-35 years\n* BMI ranges from 18-25 kg\u002Fm2\n* Positive eccentric step test\n* Anterior or retropatellar knee pain present during at least two of the following - ascending\u002Fdescending stairs, hopping\u002Frunning, squatting, kneeling and prolonged sitting\n* Pain on palpation of patellar facets\n* Insidious onset of symptoms vague and non-localized pain at anterior of knee for at least three months ( unrelated to a traumatic incident.\n\nExclusion Criteria:\n\n* Knee pain is more than 6 score on ANPRS.\n* History of traumatic patellar dislocation or subluxation\n* Osteoarthritis in the knee, ankle or hip joints, injury of cruciate ligaments or menisci\n* Previous orthopedic disorders or neurologic deficit of the lower limbs, any sensory problems, leg length discrepancy, neuromuscular disease like multiple sclerosis\n* Athletic patients.","35 Years",{"count":163,"type":21},82,"This study will be conducted to investigate the relationship between knee joint pain intensity and joint position sense accuracy in patients with patellofemoral pain syndrome (PFPS) in a single-leg squat position.",[27],[167,168,169,27],"Knee Pain","Proprioception","Single Leg Squat","2026-06-06",{"date":172,"type":35},"2026-06-11",{"date":174,"type":21},"2026-07-01",{"date":176,"type":21},"2026-11-20",{"name":41,"class":42},{"id":179,"slug":4,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":186,"briefSummary":187,"conditions":188,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":193,"leadSponsor":195,"locationsCount":4},"100642970","NCT07633782","High-Intensity Focused Electromagnetic Therapy on Patients With Patellofemoral Pain Syndrome","Effect of High-Intensity Focused Electromagnetic Therapy on Pain and Quality of Life in Patients With Patellofemoral Pain Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinical diagnosis of patellofemoral pain syndrome (anterior or peripatellar knee pain aggravated by at least two activities such as stair climbing, prolonged sitting, squatting, or running).\n* Symptoms persisting for at least 3 months.\n\nExclusion Criteria:\n\n* History of previous knee surgery or trauma (e.g., ligamentous laxity, meniscal tear, or patellar fracture).\n* Concomitant knee pathology (e.g., tibiofemoral osteoarthritis, patellar tendinopathy, or plica syndrome).\n* Presence of metallic implants, pacemakers, or electrical medical devices in the body .\n* Recent corticosteroid or hyaluronic acid injection into the affected knee within the last 3 months.\n* Pregnancy.","45 Years",{"count":138,"type":21},[24],"Evaluate the effect of High-Intensity Focused Electromagnetic Therapy on pain, quadriceps strength, and quality of life in patients with patellofemoral pain syndrome",[27],"2026-06-02",{"date":191,"type":35},"2026-06-08",{"date":147,"type":21},{"date":194,"type":21},"2026-10-08",{"name":196,"class":42},"Middle East University",{"id":198,"slug":4,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":203,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":75},"100615260","NCT07290296","Popliteus Muscle Release Versus Kinesio Taping","Popliteus Muscle Release Versus Kinesio Taping on Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n* Patients of both genders with an age range of 18-30 years old.\n* minimum 3-month history of patellofemoral pain.\n* a pain score for worst pain intensity during the previous week of 3 or more on a Visual Analog Scale (0-10, most pain).\n* reproduced by at least two of the following activities: Stair ascent or descent, hopping, running, prolonged sitting, squatting, or kneeling and present on at least one of the following clinical tests: Compression of the patella or palpation of the patellar facets.\n\nExclusion Criteria:\n\n* Clinical, x-ray, or MRI findings indicative of other specific pathology, including osteoarthritis, meniscal, ligament, or cartilage injury, or apophysitis.\n* recurrent patellar subluxation or dislocation.\n* cortisone use over an extended period of time.\n* previous surgery to the knee joint; trauma to the knee joint affecting the presenting clinical condition.\n* physiotherapy or other similar exercises for patellofemoral pain syndrome within the previous 3 months.",{"count":20,"type":21},[24],"The aim of the current study is to compare the effect of popliteus muscle release and Kinesio taping on pain intensity, function, dynamic balance, and quadriceps muscle strength in patients with patellofemoral pain syndrome.",[27],"2026-05-24",{"date":209,"type":35},"2026-05-28",{"date":211,"type":35},"2026-01-10",{"date":213,"type":21},"2026-05",{"name":41,"class":42},{"id":216,"slug":4,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":221,"targetDuration":4,"studyType":22,"phases":222,"briefSummary":223,"conditions":224,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":231,"locationsCount":75},"100638146","NCT07600827","Isokinetic Training With Blood Flow Restriction for Patellofemoral Pain Syndrome","Effects of Isokinetic Training Combined With Blood Flow Restriction in Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n* Participants aged 18 to 40 years.\n* Clinical diagnosis of patellofemoral pain syndrome (PFPS).\n* Presence of anterior or retropatellar knee pain for at least 3 months.\n* Pain provoked by at least two activities that increase patellofemoral joint load, including squatting, stair climbing, running, jumping, prolonged sitting, or kneeling.\n* Average knee pain intensity of ≥3 on a 10-point visual analog scale (VAS) during aggravating activities.\n* Ability to participate in exercise training and attend scheduled intervention sessions.\n* Willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* History of knee surgery or significant trauma to the lower extremity within the previous 12 months.\n* Clinical evidence of other knee disorders, including ligament injury, meniscal injury, patellar instability, osteoarthritis, or tendinopathy.\n* Presence of neurological, cardiovascular, or systemic musculoskeletal disorders that may affect lower limb function or exercise participation.\n* Current participation in other structured lower extremity rehabilitation or strength training programs.\n* Contraindications to blood flow restriction training, including uncontrolled hypertension, vascular disease, thromboembolic disorders, or clotting abnormalities.\n* Use of pain-relieving injections or surgical interventions for knee pain within the previous 6 months.\n* Pregnancy.\n* Inability to complete the assessment or intervention procedures.",{"count":138,"type":21},[24],"This randomized controlled trial aims to investigate the effects of isokinetic training combined with blood flow restriction (BFR) in individuals with patellofemoral pain syndrome (PFPS).",[27],"2026-05-15",{"date":227,"type":35},"2026-05-22",{"date":229,"type":35},"2026-02-25",{"date":104,"type":21},{"name":232,"class":42},"Nanjing Mingzhou Rehabilitation Hospital",{"id":234,"slug":4,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":240,"targetDuration":4,"studyType":22,"phases":242,"briefSummary":243,"conditions":244,"keywords":246,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":75},"100636187","NCT07562425","Effects of Isometric, Isotonic, and Eccentric VMO Exercises in Patellofemoral Pain Syndrome","Comparison of the Effects of Isometric, Isotonic, and Eccentric Vastus Medialis Oblique Strengthening Exercises Applied in Terminal Knee Extension Range on Pain, Function, and Muscle Architecture in Individuals With Patellofemoral Pain Syndrome: A Randomized Controlled Trial","VMO-PFPS","Inclusion Criteria:\n\n* Aged between 18 and 40 years\n* Clinically diagnosed with patellofemoral pain syndrome\n* Presence of anterior knee pain for at least 3 months\n* Pain during activities such as stair climbing, squatting, running, or prolonged sitting\n* Pain intensity of at least 3\u002F10 on the Visual Analog Scale (VAS)\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* History of knee trauma or surgery\n* Meniscal injury, ligament injury, or knee instability\n* Advanced osteoarthritis\n* Neurological disorders\n* Rheumatologic diseases\n* Participation in a structured knee rehabilitation program within the last 6 months\n* Pregnancy",{"count":241,"type":21},90,[24],"Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition characterized by anterior knee pain, especially during activities such as stair climbing, squatting, running, and prolonged sitting. Weakness or delayed activation of the vastus medialis oblique (VMO) muscle is considered an important contributing factor in the development of PFPS.\n\nThis study aims to compare the effects of three different types of VMO strengthening exercises (isometric, isotonic, and eccentric) applied within the terminal knee extension range (0-30°) on pain, functional performance, and muscle architecture in individuals with PFPS.\n\nParticipants will be randomly assigned to one of three exercise groups. All participants will receive a standardized physiotherapy program, including heat therapy, TENS, and therapeutic ultrasound, followed by group-specific VMO strengthening exercises. The intervention will be performed three times per week for 8 weeks.\n\nOutcomes will be assessed before and after the intervention and will include pain intensity (Visual Analog Scale), functional performance (WOMAC, 30-second sit-to-stand test, and stair test), and muscle architecture parameters measured by ultrasound imaging.\n\nThe results of this study are expected to provide evidence for optimizing rehabilitation strategies in individuals with PFPS.",[27,245],"Anterior Knee Pain",[247,167,98,248,249,250,251],"Vastus Medialis Oblique","Isometric Exercise","Isotonic Exercise","Eccentric Exercise","Muscle Architecture","2026-05-07",{"date":254,"type":35},"2026-05-12",{"date":256,"type":21},"2026-05-20",{"date":258,"type":21},"2026-08",{"name":260,"class":42},"Firat University",{"id":262,"slug":4,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":49,"sex":16,"minAge":268,"maxAge":18,"enrollmentInfo":269,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":270,"conditions":271,"keywords":273,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":4},"100632013","NCT07508163","Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders","Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders: Evidence From Lateral Ankle Sprain and Patellofemoral Pain Syndrome","LAS-PFPS","Inclusion Criteria:\n\nInclusion criteria for the lateral ankle sprain group will include participants with a clinically confirmed history of unilateral lateral ankle sprain, who are at least three months post-injury to avoid acute inflammatory effects, and who report residual symptoms such as pain or functional limitation. Participants in the patellofemoral pain syndrome group will have a clinical diagnosis of patellofemoral pain syndrome characterized by anterior or retropatellar knee pain aggravated by functional activities such as stair climbing, squatting, or prolonged sitting, with symptoms persisting for at least three months. Healthy control participants will have no history of lower limb musculoskeletal injury, pain, or functional impairment within the past three months and will be matched to the patient groups based on age and sex. All participants across groups will be able to stand independently without assistive devices and will demonstrate sufficient cognitive ability to understand and follow study instructions\n\nExclusion Criteria:\n\nExclusion criteria for all groups will include a history of lower limb fracture or surgery, neurological or vestibular disorders that may affect balance or postural control, uncorrected visual impairments, systemic inflammatory or rheumatological diseases, and metabolic or neurological conditions known to influence neuromuscular performance. Participants currently engaged in structured balance, proprioceptive, or neuromuscular training programs, as well as those taking medications that may affect balance or postural stability, will also be excluded from the study.","20 Years",{"count":241,"type":21},"Lateral ankle sprain (LAS) and patellofemoral pain syndrome (PFPS) are common musculoskeletal conditions associated with postural instability. However, the direction-specific nature of balance deficits and comparative patterns across these conditions remain unclear. Therefore, the aim of this study is to compare overall, mediolateral, and anteroposterior postural stability indices among individuals with LAS, PFPS, and healthy controls using the Biodex Balance System",[272,27],"Ankle Sprains",[274,275,276,277,278,14],"Postural stability","APSI","MLSI","OASI","LAS","2026-04-07",{"date":281,"type":35},"2026-04-09",{"date":283,"type":21},"2026-03-30",{"date":285,"type":21},"2026-04-27",{"name":41,"class":42},{"id":288,"slug":4,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":161,"enrollmentInfo":293,"targetDuration":4,"studyType":22,"phases":294,"briefSummary":295,"conditions":296,"keywords":297,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":4},"100628725","NCT07465380","Stabilization vs Corrective Exercise in PFP","Functional Stabilization Training VS Comprehensive Corrective Exercises on Lower Limb Kinematics in Patellofemoral Pain and Dynamic Knee Valgus","Inclusion Criteria:\n\n* Patellofemoral pain lasting \\> 6 weeks\n* Demonstrates dynamic knee valgus during single-leg squat (FPPA ≥ 10°).\n* Arabic Kujala Patellofemoral Scale (KPS) score \\\u003C 80.\n* Age 18-35 years\n\nExclusion Criteria:\n\n* Previous knee surgery; ligament\u002Fmeniscus injury; or lower-limb fractures\n* Neurologic disorders.\n* Systemic inflammatory disease\n* Pregnancy.",{"count":138,"type":21},[24],"The purpose of this study is to investigate the effects of a Functional Stabilization training program (FST) and a comprehensive corrective exercise program in PF pain and DKV.",[27],[98,298],"Genu Valgum","2026-03-07",{"date":301,"type":35},"2026-03-11",{"date":303,"type":21},"2026-04-01",{"date":305,"type":21},"2027-04",{"name":307,"class":42},"Ahram Canadian University",{"id":309,"slug":4,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":161,"enrollmentInfo":315,"targetDuration":4,"studyType":22,"phases":317,"briefSummary":318,"conditions":319,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":326,"locationsCount":75},"100627205","NCT07445607","\"Mulligan Technique vs Phonophoresis With Chitosan for Patellofemoral Pain\"","Mulligan Technique Vs Phonophoresis With Chitosan Gel on Neuromuscular Control in Patellofemoral Pain Syndrome","\"MTPP\"","Inclusion Criteria:\n\n* Insidious onset of anterior knee pain\n* Retro patellar or peripatellar pain\n* Pain duration more than four weeks (chronic\u002Fsubacute)\n* Pain severity ≥ 3\u002F10 on Visual Analog Scale (VAS)\n* Pain during at least two of the following activities: stair ascent or descent, squatting, prolonged sitting (theater sign), or kneeling\n* Positive patellar compression test (pain reproduced by compressing the patella into the trochlear groove)\n* Patellar tenderness along the medial or lateral borders\n* Age between 18 and 35 years\n* Baseline Kujala score (Arabic version): approximately 67-71 (indicating moderate to severe dysfunction)\n\nExclusion Criteria:\n\n* Traumatic injury (e.g., dislocation, fracture, ligament or meniscus pathology)\n* Inflammatory arthritis (e.g., rheumatoid arthritis, gout)\n* Prior knee surgery\n* Current use of NSAIDs or corticosteroids",{"count":316,"type":21},45,[24],"Patellofemoral pain syndrome (PFPS) is a common knee condition causing pain and dysfunction. This study aims to compare the effectiveness of two physical therapy treatments for PFPS: Mulligan mobilization with movement technique versus phonophoresis with chitosan gel.\n\nForty-five participants with patellofemoral pain syndrome will be randomly assigned to one of three groups: (1) Mulligan technique group, (2) Phonophoresis with chitosan gel group, or (3) Control group receiving standard physical therapy exercises. Each group will receive treatment 3 times per week for 4 weeks.\n\nThe researchers want to determine which treatment is more effective in improving neuromuscular control, reducing pain, and improving function in patients with patellofemoral pain syndrome. Participants will be assessed before and after the treatment period.\n\nThis study may help physical therapists and healthcare providers choose the most effective treatment approach for patients with patellofemoral pain.",[27],"2026-02-27",{"date":322,"type":35},"2026-03-03",{"date":324,"type":21},"2026-02-15",{"date":258,"type":21},{"name":307,"class":42},{"id":328,"slug":4,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":332,"targetDuration":4,"studyType":22,"phases":334,"briefSummary":335,"conditions":336,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":75},"100277373","NCT02890485","The Effects of Dry Needling on Patients With Knee Pain","Inclusion Criteria:\n\n* 18-40 years-of-age\n* Referred for physical therapy\n* Presence of anterior knee pain around the patella during ascending\u002Fdescending stairs, squatting, and\u002For running for at least 3 months.\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Bilateral patellofemoral pain syndrome\n* Received previous dry needling treatments\n* Pregnancy\n* History of pain less than 3 months\n* Imaging demonstrating the presence of confounding internal abnormality (e.g. chondral defects, ligamentous injury, and\u002For meniscal pathology),\n* Patellar instability\n* Presence of a neurological condition that would affect movement\n* Contraindications to dry needling techniques (e.g. a history of bleeding disorders, phobia of needles, an active cancer diagnosis, and presence of other systemic illness such as fever or signs of infection)\n* Actively receiving treatment for knee pain outside of the current study protocol while enrolled in the study;\n* received active and supervised PT treatment for knee pain within the last 4 weeks;\n* history of knee surgery less than 6 months ago\n* history of surgical correction of the patellofemoral complex (e.g. MPFL reconstruction, patellar realignment surgery, etc)",{"count":333,"type":21},120,[24],"This study is testing the effectiveness of \"dry needling\" for pain management and on muscle strength and leg function for those with knee pain. Dry needling consists of small, monofilament needles that are administered directly into the tissue and manipulated to make the muscle relax for pain relief. This technique is used to treat dysfunctions in skeletal muscle and connective tissue to help diminish pain, reduce impairments of body structure and restore function.",[27,89],"2026-02-23",{"date":229,"type":35},{"date":340,"type":35},"2016-08",{"date":342,"type":21},"2030-12",{"name":344,"class":42},"Ohio State University",{"id":346,"slug":4,"hasResults":11,"nctId":347,"briefTitle":348,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":350,"targetDuration":4,"studyType":22,"phases":352,"briefSummary":353,"conditions":354,"keywords":356,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":369},"100625529","NCT07423819","Sports Rehabilitation Therapy for Knee Joint Sports Injuries: A Case Study of Anterior Cruciate Ligament Injury and Patellar Chondromalacia","Inclusion Criteria:\n\n1. Age 18-50 years.\n2. Clinical symptoms, signs, and MRI diagnosis confirming ACL rupture.\n3. First-time unilateral ACL rupture.\n4. Clinical symptoms, signs, and MRI diagnosis confirm patellofemoral cartilage injury.\n5. Presence of at least one of the following manifestations:\n\n   1. Initially, unilateral knee presents with dull pain, soreness, or a sense of weakness, followed by increased knee pain predominantly located behind the patella. Pain worsens after exertion, with difficulty climbing up or down stairs, and alleviates or disappears after rest. The pain VAS score is ≤6 points.\n   2. Positive unilateral knee patellar grind test and\u002For positive patellar compression test and\u002For positive squat test.\n6. Ability to understand and sign the informed consent form, voluntarily participate in the study, and cooperate with follow-up.\n\nExclusion Criteria:\n\n1. Body Mass Index (BMI) less than 18.5 or greater than 35 kg\u002Fm²;\n2. Age greater than 50 years or less than 18 years;\n3. History of knee surgery or presence of other conditions, such as tumors, rheumatoid arthritis, tuberculosis, etc.;\n4. Severe cardiopulmonary dysfunction, neurological disorders, or other conditions unsuitable for exercise rehabilitation;\n5. Pregnant or lactating women;\n6. Individuals unwilling to undergo this treatment method.",{"count":351,"type":21},160,[24],"The primary objective of this clinical trial is to verify the superiority of a digital diagnosis and treatment system for the conservative management of knee sports injuries-based on wearable sensors, machine vision, and large language models-over conventional off-site rehabilitation in terms of functional outcomes. The secondary objectives include assessing safety and adverse events, compliance and feasibility, algorithm evaluation accuracy and usability, and generating clinical evidence to support the registration of a Class II medical device. Participants will undergo a six-month intervention comprising knee muscle strengthening exercises, lower limb balance and stability training, and stretching exercises. Follow-up assessments will be conducted every four weeks, recording IKDC and Lysholm subjective knee function scores, VAS pain scores, SF-36 quality of life scores, knee range of motion, and MRI findings.",[355,27],"Anterior Cruciate Ligament Injury",[357,358,359],"Anterior cruciate ligament","patella","Sports rehabilitation","2026-02-13",{"date":362,"type":35},"2026-02-20",{"date":364,"type":21},"2026-03-15",{"date":366,"type":21},"2026-11-30",{"name":368,"class":42},"Peking University Third Hospital",4,{"id":371,"slug":4,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":375,"eligibilityCriteria":376,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":184,"enrollmentInfo":377,"targetDuration":4,"studyType":22,"phases":378,"briefSummary":379,"conditions":380,"keywords":381,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":75},"100624545","NCT07411027","Body Awareness-Based Rehabilitation on Physical Psychosocial Status in Patellofemoral Pain Syndrome","The Effects of Body Awareness-Based Sensorimotor Rehabilitation on Physical Psychosocial Status in Patellofemoral Pain Syndrome","BASPR-PFP","Inclusion Criteria:\n\n* Adults aged 18-45 years.\n* Clinical diagnosis of patellofemoral pain syndrome with anterior or retropatellar knee pain.\n* Knee pain lasting for at least 3 months.\n* Pain intensity of at least moderate level during functional activities such as stair climbing, squatting, or prolonged sitting.\n* Ability to understand and follow instructions and provide informed consent.\n* Willingness to participate in the rehabilitation program.\n\nExclusion Criteria:\n\n* History of knee surgery within the past 12 months.\n* Presence of other knee pathologies (e.g., ligament injury, meniscal tear, osteoarthritis).\n* Diagnosis of inflammatory or rheumatological diseases.\n* Neurological disorders affecting balance or movement.\n* Current pregnancy.\n* Participation in another structured physiotherapy or rehabilitation program within the past 3 months.\n* Any condition that may prevent safe participation in exercise.",{"count":138,"type":21},[24],"Patellofemoral pain syndrome is a common knee condition that causes pain around or behind the kneecap, especially during activities such as walking, climbing stairs, squatting, or prolonged sitting. This condition can affect daily activities, movement quality, and psychological well-being.\n\nThe purpose of this study is to investigate the effects of a body awareness-based sensorimotor rehabilitation program on pain behavior, movement quality, and psychosocial outcomes in individuals with patellofemoral pain syndrome.\n\nParticipants will be randomly assigned to either an intervention group receiving body awareness-based sensorimotor rehabilitation or a control group receiving conventional physiotherapy exercises. The rehabilitation program will focus on improving body awareness, posture, balance, and controlled movement patterns.\n\nOutcomes will be assessed before and after the intervention period. The main outcomes include changes in pain-related behaviors, movement quality, and psychosocial status.\n\nThe results of this study are expected to provide evidence on whether body awareness-based sensorimotor rehabilitation can be an effective approach for managing patellofemoral pain and improving both physical and psychological aspects of function.",[27],[143,382,383],"Body awareness","Physiotherapy","2026-02-06",{"date":360,"type":35},{"date":387,"type":21},"2026-02-01",{"date":389,"type":21},"2026-06-01",{"name":391,"class":42},"Recep Tayyip Erdogan University",{"id":393,"slug":4,"hasResults":11,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":161,"enrollmentInfo":398,"targetDuration":4,"studyType":22,"phases":400,"briefSummary":401,"conditions":402,"keywords":403,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":75},"100617466","NCT07318987","EFFECT OF SAPHENOUS NERVE RELEASE ON PATIENTS WITH PATELLOFEMORAL PAIN SYNDROME","EFFECT OF SAPHENOUS NERVE RELEASE ON PAIN,BALANCE AND FUNCTION IN PATIENTS WITH PATELLOFEMORAL PAIN SYNDROME","Inclusion Criteria:\n\n1 - Age from 18 to 35 and BMI 18 to 25 kg\u002Fm2. 2. Both gender (male and female) 3. Patients who had anterior knee pain for at least six weeks 4. Patients with positive saphenous neurodynamic test (SAPHNT)\n\nExclusion Criteria:\n\n1. Knee replacement\n2. An intraarticular injection within the past 3 months\n3. Previous operative treatment or arthroscopy, other secondary knee-related problems (bursitis, tendinopathy, osteochondritis, neuromas, intraarticular pathology (such as osteoarthritis), tumor, and rheumatologic diseases\n4. Diabetic neuropathic pain or fibromyalgia",{"count":399,"type":21},36,[24],"Patellofemoral Pain Syndrome (PFPS) is a frequent cause of anterior knee pain in young, physically active individuals, especially females, and is commonly managed with quadriceps and hip-focused exercises. However, the role of neural factors has been largely overlooked. The saphenous nerve, which supplies sensation to the anteromedial knee, may become irritated or entrapped and contribute to pain and neuromuscular dysfunction in PFPS. This study suggests that manual therapy targeting the saphenous nerve could improve pain, function, and balance, providing a more holistic approach to PFPS rehabilitation.",[27],[404,405,406,407,408],"PATELLOFEMORAL PAIN SYNDROME","Balance","pain","knee function","saphenous nerve","2025-12-21",{"date":411,"type":35},"2026-01-06",{"date":413,"type":35},"2025-10-10",{"date":415,"type":21},"2026-01-27",{"name":41,"class":42},{"id":418,"slug":4,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":82,"enrollmentInfo":423,"targetDuration":4,"studyType":22,"phases":425,"briefSummary":426,"conditions":427,"keywords":429,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":440},"100555820","NCT06517056","Emovi 3D Knee Assessment Device Intervention for Operational Readiness","Objective Dynamic and 3D Knee Assessment Medical Device to Improve Recovery and Accelerate Return to Readiness in Service Members With Knee Pain","Inclusion Criteria:\n\n* Age 18-50\n* Active Duty Service Member stationed at Fort Liberty and Schofield Barracks\n* Diagnosis of patellofemoral pain (ICD-10 codes: M25.2 (pain in unspecified knee), M25.561 (pain in right knee), and M25.562 (pain in left knee)\n\nExclusion Criteria:\n\n* Pregnancy\n* Known to be leaving that duty station within next 3 months\n* Concurrent lower limb injuries (examples include but are not limited to ankle sprain or HS strain)\n* Previous knee surgery\n* History of traumatic knee injury, such as a ligament tear or meniscal tear\n* Presence of rheumatoid or neurological disease",{"count":424,"type":21},180,[24],"This is a randomized clinical trial investigating the use of the Emovi Knee Kinesiography information in the treatment of anterior knee pain in physical therapy.",[428,27],"Patellofemoral Pain",[428,27],"2025-07-10",{"date":432,"type":35},"2025-07-16",{"date":434,"type":35},"2024-10-24",{"date":436,"type":21},"2025-10",{"name":438,"class":439},"Womack Army Medical Center","FED",2,{"id":442,"slug":4,"hasResults":11,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":4,"eligibilityCriteria":446,"healthyVolunteers":11,"sex":16,"minAge":268,"maxAge":113,"enrollmentInfo":447,"targetDuration":4,"studyType":22,"phases":448,"briefSummary":449,"conditions":450,"keywords":451,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":461,"locationsCount":75},"100597865","NCT07064044","Muscle Energy Technique With and Without Patellar Inferior Glide in Patients With Patellofemoral Pain Syndrome","Effects of Muscle Energy Technique With and Without Patellar Inferior Glide on Pain, Range of Motion and Disability in Patients With Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n* Individuals with age 20-40Years\n* Pain rating \\> 3 and \\\u003C 7 on NPRS\n* Patella alta confirmed with ISI (Insall Salvati index) ratio \\> 1.2 on lateral knee radiograph\n* Positive Ely's test for rectus femoris tightness\n* Positive eccentric step test\n\nExclusion Criteria:\n\n* History of patellofemoral dislocation\n* Knee osteoarthritis\n* Recently undergo to surgery to knee\n* Fracture in knee region\n* Positive patellar tap test for knee joint effusion\n* Lateral and medial tracking of patella\n* Patients taking NSAIDs and corticosteroids",{"count":399,"type":21},[24],"Patellofemoral pain syndrome (PFPS) is one of the most commonly diagnosed conditions among adolescents and adults with knee complaints, accounting for approximately 25% of knee disorders diagnosed in sports medical clinics. While the etiology of PFPS is suggested to be multifactorial, several contributing factors such as lower knee extensors strength, quadriceps imbalance, weak hip abductors and overuse have been identified.",[27],[452,453,454],"Pain","Disability","Range of motion","2025-07-03",{"date":457,"type":35},"2025-07-14",{"date":459,"type":21},"2025-07",{"date":436,"type":21},{"name":462,"class":42},"Riphah International University",{"id":464,"slug":4,"hasResults":11,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":49,"sex":16,"minAge":469,"maxAge":161,"enrollmentInfo":470,"targetDuration":4,"studyType":22,"phases":472,"briefSummary":473,"conditions":474,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":75},"100559655","NCT06566950","BFR Training on Muscle Morphology","Effectiveness of Blood Flow Restriction Training on Muscle Morphology and Prevention of Patellofemoral Pain Syndrome and Anterior Cruciate Ligament Injury","Inclusion Criteria:\n\n* Being between the ages of 15 and 35\n* Play level 1 sports (fight martial arts, basketball, futsal, and soccer) at least twice a week\n* Never experienced an Patellofemoral Pain Syndrome or ACL injury before\n* Never experienced a grade III sprain or strain\n* Consent to participate in the study until its conclusion and provide informed consent.\n\nExclusion Criteria:\n\n* Having a tumor, cancer, vena thromboembolic disease, obesity, diabetes, hypertension, anemia, and renal failure\n* Disabilities or those who are disabled.","15 Years",{"count":471,"type":21},75,[24],"This randomized clinical trial study compares high-load eccentric training (HL-Et), sham LL-BFRt, and low-load blood flow restriction (LL-BFRt) in sportsmen. The primary inquiries it seeks to address are:\n\nIs LL-BFR superior to HL-Et and sham LL-BFRt in terms of improving muscle morphology? Is LL-BFR a more effective Patellofemoral Pain Syndrome and ACL injury preventive than HL-Et and sham LL-BFRt?\n\nThe three intervention groups that will be randomly assigned to participants are LL-BFRt, sham LL-BFRt, and HL-Et. Participants are expected to carry out:\n\nParticipants in LL-BFRt will be required to perform LL eccentric training at 30% of their repetition maximum (RM) and 70% of their artery occlusion pressure (AOP). This training will include stairs, single leg squat, and single leg deadlift.\n\nParticipants in HL-Et will be required to perform LL eccentric training at 70% of their maximum number of repetitions (RM).\n\nIn order to determine whether muscular morphology and the prevention of Patellofemoral Pain Syndrome and ACL injury improve following the interventions and follow-up, researchers will compare LL-BFRt, sham LL-BFRt, and HL-Et.",[475,476,477,27,478],"Blood Flow Restriction Training","Eccentric Training","Muscle Morphology","Anterior Cruciate Ligament Injuries","2025-06-27",{"date":481,"type":35},"2025-06-29",{"date":483,"type":35},"2024-09-20",{"date":485,"type":21},"2025-11-20",{"name":487,"class":42},"Udayana University",{"id":489,"slug":4,"hasResults":11,"nctId":490,"briefTitle":491,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":493,"targetDuration":4,"studyType":22,"phases":495,"briefSummary":496,"conditions":497,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":75},"100593318","NCT07004881","Comparison Between the Effects of Mulligan and Maitland Mobilization on Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n* Referred patients from rehabilitation, orthopedic and rheumatology department\n* Both males and females of age 18-40 years\n* Having pain from at least 2 months.\n* Pain score ≥ 3 on NPRS.\n* Pain on palpation of medial or lateral Patellar facet. (12, 13)\n* Retro patellar pain in at least two of the following activities:\n* Ascending , descending stairs\n* Hopping \u002F jumping\n* prolonged sitting with flexed knees\n* kneeling and squatting\n* Patellar tilt test\n\n  * EXCLUSION CRIETERIA:\n* Positive tests\u002Ffindings on physical examination for knee menisci, ligaments and bursa.\n* Chondromalacia patellae\n* Individuals with Instability of tibiofemoral joint\n* lower extremity surgery\n* Rheumatoid arthritis, other connective tissue disorders and congenital deformities.",{"count":494,"type":21},40,[24],"This study is a randomised control trial and the purpose of this study is to investigate and compare the \"Effects of Maitland mobilizations and Mulligan Mobilization With Movement (MWM) in patients with Patellofemoral Pain Syndrome",[27],"2025-06-13",{"date":500,"type":35},"2025-06-18",{"date":502,"type":35},"2024-07-15",{"date":504,"type":21},"2025-07-15",{"name":506,"class":42},"Foundation University Islamabad",{"id":508,"slug":4,"hasResults":11,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":14,"eligibilityCriteria":512,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":513,"enrollmentInfo":514,"targetDuration":4,"studyType":22,"phases":515,"briefSummary":516,"conditions":517,"keywords":520,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":75},"100593990","NCT07013617","Effect of Specific Versus General Hamstring Stretch on Clinical Outcomes in Patellofemoral Pain Syndrome (PFPS)","Effect Of Hamstring Stretch On Clinical Outcomes In Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n* Anterior or retropatellar knee pain lasting at least three months\n* Pain reproduced by at least two functional tasks: squatting, kneeling, prolonged sitting, stair climbing, hopping or running\n* Pain intensity of ≥3 on a Visual Analog Scale\n* positive active knee extension test (inability to achieve greater than 160° of knee extension with the hip at 90° of flexion)\n* Body mass index (BMI) \\\u003C 30 Kg\u002Fm² and \\> 18Kg\u002Fm²\n\nExclusion Criteria:\n\n* Previous knee surgery\n* History of knee pathologies, such as meniscal injury' ligament injury, or knee osteoarthritis\n* Psychological, cardiovascular' or neurological disorders\n* Dizziness or fainting while doing exercises, pregnancy, or any contraindications to exercise\n* Physical therapy treatment in the last 3 months","37 Years",{"count":138,"type":21},[24],"This randomized, Single-blind, parallel-group trial will compare the effects of three hamstring stretching interventions-general hamstring Muscle Energy Technique (MET), medial hamstring MET, and lateral hamstring MET-each combined with standardized TENS and progressive hip\u002Fknee strengthening, on hamstring flexibility (knee-extension ROM), anterior knee pain (Arabic Kujala score), pain intensity visual analogue scale (VAS), and lower-limb strength (hand-held dynamometer) in adults with patellofemoral pain syndrome (PFPS).",[518,27,519,92],"Hamstring Shortness","Hamstring Flexibility",[521,14,522,523,524,525,526,527,528,529,530,531],"patellofemoral pain syndrome","hamstring flexibility","active knee extension test","medial hamstring","lateral hamstring","specific hamstring stretch","Muscle Energy Technique","TENS","Visual Analogue Scale","Hand Held Dynamometer (HHD)","Kujala Score","2025-06-11",{"date":534,"type":35},"2025-06-15",{"date":536,"type":21},"2025-06-14",{"date":538,"type":21},"2025-11",{"name":41,"class":42},{"id":541,"slug":4,"hasResults":11,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":4,"eligibilityCriteria":545,"healthyVolunteers":11,"sex":16,"minAge":268,"maxAge":113,"enrollmentInfo":546,"targetDuration":4,"studyType":22,"phases":548,"briefSummary":549,"conditions":550,"keywords":551,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":559,"completionDateStruct":561,"leadSponsor":563,"locationsCount":75},"100583398","NCT06875804","Compressive Myofascial Release of the Vastus Lateralis on Lateral Patellar Tracking in Patellofemoral Pain Syndrome","Effects of Compressive Myofascial Release of the Vastus Lateralis on Lateral Patellar Tracking in Patients With Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n* Age group between 20 to 40 years\n* Male and female gender\n* Diagnosed cases of Patellofemoral syndrome\n* Participants with positive J sign and Clarke's test\n* Pain provoked during knee loading physical activity, such as jumping, running, squatting, or going up or down stairs in last 3 months\n* Presence of excessive lateral patellar tracking on axial view radiographs\n\nExclusion Criteria:\n\n* History of knee surgery in the past year.\n* Any contraindications to myofascial release therapy, such as active infections, open wounds.\n* Presence of hip pathology or other knee conditions such as ligament tears, meniscal injuries, Osgood-Schlatter or Sinding-Larsen-Johanssen syndrome or jumpers knee\n* Participants with a history of trauma or repetitive episodes of patellar subluxation or dislocation\n* Use of intra-articular corticosteroid injections\n* Presence of auto-immune disorder (spondylolisthesis, spondylitis, Rheumatoid arthritis etc.) other than knee OA or systemic conditions such as severe cardiovascular disease",{"count":547,"type":21},24,[24],"Patellofemoral Pain Syndrome is a prevalent condition characterized by anterior knee pain, often exacerbated by activities such as squatting, running, and stair climbing. This condition is frequently associated with improper patellar tracking, particularly lateral displacement, which can be influenced by various factors including muscular imbalances and tightness. The vastus lateralis muscle, part of the quadriceps group, is often implicated in contributing to lateral patellar tracking due to its attachment and alignment. Compressive myofascial release (CMFR) is a therapeutic technique aimed at reducing muscle tightness and restoring optimal muscle function. This study will explore the effects compressive myofascial release on the vastus lateralis in improving patellar tracking in patients diagnosed with Patellofemoral Pain Syndrome.The methodology of this study involves a randomized controlled trial with a sample of patients diagnosed with Patellofemoral Pain Syndrome. Non-probability convenience sampling technique will be used and participants will be recruited in groups after randomization. Participants(n=26) will be divided into two groups: the intervention group (n=13) receiving compressive myofascial release on the vastus lateralis, and a control group receiving(n=13) a routine treatment. The intervention will be administered over a period of four weeks, with sessions occurring three times weekly. Patellar tracking will be assessed using q-angle analysis both pre- and post-intervention. Additionally, subjective measures of pain and functional ability will be evaluated using the Numeric pain rating scale (NPRS) and the Kujala Patellofemoral Score. Data analysis will focus on comparing the changes in lateral patellar displacement and patient-reported outcomes between the two groups to determine the efficacy of compressive myofascial release in correcting lateral patellar tracking and alleviating symptoms of Patellofemoral Pain Syndrome. SPSS version 25 will be used for data analysis",[27],[27,552,553,554,555,452,454],"Myofascial Release","Vastus Lateralis","Patellar Tracking","Knee joint","2025-03-10",{"date":558,"type":35},"2025-03-13",{"date":560,"type":35},"2025-01-02",{"date":562,"type":21},"2025-09-15",{"name":462,"class":42},{"id":565,"slug":4,"hasResults":11,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":161,"enrollmentInfo":570,"targetDuration":4,"studyType":22,"phases":571,"briefSummary":572,"conditions":573,"keywords":574,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":579,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":585,"locationsCount":75},"100562088","NCT06598618","Comparison of IASTM and Muscle Energy Technique in Patellofemoral Pain Syndrome.","Compare the Effects of Instrument Assisted Soft Tissue Mobilization (IASTM) and Muscle Energy Technique on Iliotibial Band Tightness in Patients With Patellofemoral Syndrome.","Inclusion Criteria:\n\n* • Age between 18 and 35 years\n\n  * Both Genders.\n  * Anterior or retro patellar knee pain for at least the past 3 months.\n  * Knee pain during at least 3 of the following activities: ascending\u002Fdescending stairs, squatting, hopping\u002F running, and prolonged sitting.\n  * Retro patellar pain in patellar grind test (positive clarke's sign).\n  * A score of at least 3 on the visual analog scale (VAS).\n  * Positive Ober's test.\n\nExclusion Criteria:\n\n* • Any meniscal or ligament tears of knee.\n\n  * Knee osteoarthritis.\n  * Any previous surgery of lower limb.\n  * Patellar fracture or fracture of lower extremity.\n  * Having received knee injections of corticosteroids or hyaluronic acid.\n  * Osteoporosis of knee joint.",{"count":20,"type":21},[24],"The aim of this randomized controlled trial is to compare the effect of Instrument Assisted Soft Tissue Mobilization (IASTM) and muscle energy technique on iliotibial band tightness on pain, range of motion and functional mobility in patients with patellofemoral pain syndrome.",[27],[575,576,577,521],"IASTM","MET","iliotibial band","2025-02-20",{"date":580,"type":35},"2025-02-21",{"date":582,"type":35},"2024-10-02",{"date":584,"type":21},"2025-09-28",{"name":462,"class":42},{"id":587,"slug":4,"hasResults":11,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":4,"eligibilityCriteria":591,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":161,"enrollmentInfo":592,"targetDuration":4,"studyType":22,"phases":594,"briefSummary":595,"conditions":596,"keywords":597,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":75},"100574343","NCT06758050","Effect of Core Exercises on Patellofemoral Pain Syndrome","Effect of Adding Core Exercises to Hip and Knee-focused Exercises on Patellofemoral Pain Syndrome","Inclusion Criteria:\n\n1. Patients of both genders with an age range of 18- 35 years old.\n2. Gradual development of pain in the front of the knee lasting more than 12 weeks.\n3. Patients with body mass index 18- 25 kg m2.\n4. Pain is aggravated by at least 2 of the following activities: jumping, running, prolonged sitting, stair climbing, kneeling, and squatting.\n\n   1. Positive patellar grinding test.\n   2. Insidious onset of symptoms, unrelated to a traumatic damage.\n\nExclusion Criteria:\n\n1. Traumatic patellar subluxation or dislocation.\n2. A history of any of the following conditions: meniscal or other intra articular pathologic conditions; cruciate or collateral ligament involvement.\n3. Any lower limb bony or congenital deformities.\n4. Previous knee and hip joint surgeries.\n5. Osteoarthritis in the ankle, knee, or hip joints.\n6. Conditions that affect muscle strength such as diabetes mellitus or rheumatoid arthritis.",{"count":593,"type":21},44,[24],"the goal of this interventional study is to Investigate the effect of core strengthening exercises on pain, strength, function, and balance in patients with PFPS.",[27],[598],"core strengthening exercises, hip and knee-focused exercises, patellofemoral pain syndrome","2024-12-26",{"date":601,"type":35},"2025-01-03",{"date":603,"type":35},"2024-08-04",{"date":605,"type":21},"2025-01-30",{"name":41,"class":42},""]