[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pcosinsulin-resistant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pcosinsulin-resistant":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100616597",false,"NCT07307677","Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to Metformin","Effect of Melatonin and Metformin Combination Therapy on Clinical and Biochemical Parameters inInsulin Resistant Polycystic Ovary Syndrome Compared to Metformin Alone","Inclusion Criteria:\n\n* Diagnosed case of PCOS according to Rotterdam criteria\n* Women of age 18-35 years\n* Insulin resistance (HOMA-IR \\>2.6)\n\nExclusion Criteria:\n\n* BMI: ≤ 18.5 and ≥ 30 kg\u002Fm2\n* Uncontrolled endocrine disorders (Diabetis melitus, Hypothyroidism, Hyperprolactinemia)\n* Known case of any medical disease (Renal, hepatic or cardiac disease)\n* Any medication which would affect insulin resistance (Metformin, Myo- inositol, Pioglitazone) in last three months.\n* Hypersensitivity to melatonin.","FEMALE","18 Years","35 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","Women with polycystic ovary syndrome with HOMA-IR \\>2.6 fulfilling inclusion and exclusion criteria will be randomly allocated into two groups:experimental group: A (Melatonin 3mg and Metformin 500mg) and control group: B (Metformin 500mg). Each group will be contained 30 selected patients.\n\nGroup B:Tab. Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks.\n\nOutcome variables will be measured after three months, will be meticulously recorded for analysis and comparison.",[26],"PCOS(Insulin Resistant)",[28],"Melatonin in PCOS","RECRUITING","2026-01-05",{"date":32,"type":33},"2026-01-07","ACTUAL",{"date":35,"type":33},"2025-03-11",{"date":37,"type":20},"2026-08-10",{"name":39,"class":40},"Mst.Sumyara Khatun","OTHER",""]