[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"reduced-ejection-fraction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:reduced-ejection-fraction":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100607729",false,"NCT07192341","Sacubitril\u002FValsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection Fraction","Effect of Sacubitril\u002FValsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection Fraction","Inclusion Criteria:\n\n* Age ≥ 18 years old.\n* Both sexes.\n* Patients with a history of prosthetic heart valves.\n* Patients diagnosed with heart failure with reduced ejection fraction (HFrEF), defined as left ventricular ejection fraction (LVEF) ≤ 40% with New York Heart Association (NYHA) functional class II-IV.\n\nExclusion Criteria:\n\n* Hemodynamic instability.\n* Use of a circulatory auxiliary circulation device.\n* Severe hepatic \\[alanine aminotransferase (ALT) \\>120 U\u002FL\\] and renal insufficiency \\[estimated glomerular filtration rate (eGFR) \\\u003C30 mL\u002Fmin\\].\n* Blood pressure \\\u003C100\u002F60 mmHg.\n* Serum potassium \\>5.3 mmol\u002FL.\n* Severe pulmonary hypertension.\n* Malignant arrhythmia.\n* Malignant tumor.\n* Known history of hereditary or primary angioedema.\n* Serious adverse drug reactions or serious complications over the course of treatment.","ALL","18 Years",{"count":18,"type":19},220,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study aims to evaluate the effect of sacubitril\u002Fvalsartan in patients with prosthetic heart valves with heart failure with reduced ejection fraction (HFrEF).",[25,26,27,28],"Sacubitril\u002FValsartan","Prosthetic Heart Valve","Heart Failure","Reduced Ejection Fraction","RECRUITING","2025-09-27",{"date":32,"type":33},"2025-09-30","ACTUAL",{"date":30,"type":33},{"date":36,"type":19},"2026-02-01",{"name":38,"class":39},"Kafrelsheikh University","OTHER",""]