[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"regional-citrate-anticoagulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:regional-citrate-anticoagulation":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":16,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100517710",false,"NCT06021080","Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions","Inclusion Criteria:\n\n1. Age ≥ 18 years old;\n2. Receiving citrate anticoagulation;\n3. Obtain Informed consent from patients or next of kin.\n\nExclusion Criteria:\n\n1. Pregnant or lactating women;\n2. Allergic to citrate anticoagulants;\n3. Severe liver dysfunction (total bilirubin levels exceeding two times the normal range);\n4. Hypoxemia (PaO2 \\\u003C 60 mmHg);\n5. Inadequate tissue perfusion (blood pressure \\\u003C 90\u002F60 mmHg despite high doses of vasoactive agents);\n6. Hyperlactatemia (lactate\\> 4 mmol\u002FL);\n7. Hypernatremia;\n8. Estimated length of hospital stay \\\u003C 48h;\n9. Participated in other studies.","ALL","18 Years","100 Years",{"count":18,"type":19},30,"ESTIMATED","1 Month","OBSERVATIONAL","It is unclear whether different modes of continuous renal replacement therapy (CRRT) impact post-filter ionized calcium concentrations during regional citrate anticoagulation (RCA) when using calcium-containing replacement fluid.\n\nThis prospective, single-center, observational cohort study will screen all patients receiving CRRT for eligibility. General clinical information will be collected before commencing CRRT treatment. Patients will be randomly assigned to either the veno-venous hemofiltration (CVVH) or continuous veno-venous hemodialysis (CVVHD) group and switch to the alternative mode in the subsequent treatment session. Pre-filter and post-filter ionized calcium, systemic total and ionized calcium, and effluent total and ionized calcium will be measured 2 hours after the initiation of CRRT. Electrolyte levels, arterial blood gases, hourly citrate dose, and total citrate dose will be recorded every 6 hours until the end of CRRT. The primary outcome is the difference in ionized calcium concentrations at each site over time between the two modes.",[24,25,26],"Renal Injury","Regional Citrate Anticoagulation","Continuous Renal Replacement Therapy",[24,28,29],"Regional citrate anticoagulation","Continuous renal replacement therapy","RECRUITING","2025-08-05",{"date":33,"type":34},"2025-08-06","ACTUAL",{"date":36,"type":34},"2023-10-09",{"date":38,"type":19},"2026-12-09",{"name":40,"class":41},"Fujian Provincial Hospital","OTHER",""]