[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"right-bundle-branch-block\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:right-bundle-branch-block":68},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100459661",false,"NCT05265520","His-Bundle Corrective Pacing in Heart Failure","HIS-CRT","Inclusion Criteria:\n\n* Age 18 years or older (no upper age limit)\n* Optimal medical therapy for heart failure by current guidelines\n* Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:\n\n  * New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR\n  * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR\n  * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb)\n\nExclusion Criteria:\n\n* Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization\n* Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology\n* Unable or unwilling to follow study protocol\n* Less than 12 months life expectancy at consent\n* Pregnancy or planned pregnancy during duration of the study\n* On heart transplant list or likely to undergo heart transplant","ALL","18 Years",{"count":18,"type":19},120,"ESTIMATED","INTERVENTIONAL",[22],"NA","The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).",[25,26,27,28],"Right Bundle-Branch Block","Heart Failure","His-bundle Pacing","Cardiac Resynchronization Therapy","RECRUITING","2026-02-04",{"date":32,"type":33},"2026-02-09","ACTUAL",{"date":35,"type":33},"2022-12-02",{"date":37,"type":19},"2028-07-01",{"name":39,"class":40},"University of Rochester","OTHER",14,{"id":43,"slug":4,"hasResults":10,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":10,"sex":15,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100507578","NCT05889208","Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Valve Implantation","TAVI-PACE","Inclusion Criteria:\n\n* Patients undergoing TAVI indicated by severe valvular aortic stenosis\n* Written informed consent\n* Left ventricular ejection fraction ≥ 40 %\n* Persistent RBBB in 12-lead electrocardiogram (RSR' pattern in V1-3, QRS duration \\> 120 milliseconds, and wide S wave in leads I, aVL, V5-6)\n\nExclusion Criteria:\n\n* Other indications for pacemaker implantation or previously implanted pacemaker\n* Life expectancy \\\u003C 1 year\n* No written informed consent","70 Years",{"count":50,"type":19},320,[22],"The goal of this clinical trial is to learn about the safety and outcome of prophylactic pacemaker implantation in patients with right bundle-branch block undergoing trans-catheter aortic valve (TAVI) implantation in patients with severe aortic stenosis and left ventricular ejection fraction.Participants will be randomized to:\n\n* Prophylactic pacemaker implantation prior TAVI\n* Conservative strategy",[54,25],"Aortic Stenosis",[56,57],"Trans-catheter aortic valve implantation","Pacemaker","NOT_YET_RECRUITING","2023-05-26",{"date":61,"type":33},"2023-06-05",{"date":63,"type":19},"2023-12-01",{"date":65,"type":19},"2027-12-01",{"name":67,"class":40},"Aalborg University Hospital",""]