[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skeletal-muscle-ultrasound\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skeletal-muscle-ultrasound":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100641671",false,"NCT07647393","Ultrasound Muscle Biomarkers as Predictors of Isometric Quadriceps Muscle Strength and Handgrip in Healthy Adults: an Observational Study","MUSCLE-US","Inclusion Criteria:\n\n* Healthy adults aged 18-89 years.\n* Resident in Spain for at least 5 years.\n* Living independently in the community and able to complete all study assessments.\n* Able to understand and follow verbal instructions in Spanish.\n* Able and willing to provide written informed consent prior to study participation.\n\nExclusion Criteria:\n\n* Neurological, musculoskeletal, or systemic disorders affecting muscle strength or mobility.\n* Recent surgery or acute injury affecting the upper or lower limbs.\n* Recent use of medications affecting the musculoskeletal system (e.g., systemic corticosteroids for \\>1 week during the previous 6 months or muscle relaxants during the previous week).\n* Cognitive or psychiatric conditions limiting participation.\n* Pregnancy.\n* Recent postpartum period (≤3 months after delivery).\n* Presence of clinically relevant pain, fatigue, physical deconditioning, or functional limitations that may interfere with study procedures or measurement validity.\n* Acute illness at the time of assessment.\n* Uncontrolled hypertension (≥140\u002F90 mmHg).\n* Resting peripheral oxygen saturation ≤90%.\n* Moderate-to-severe pain (Numeric Rating Scale ≥4\u002F10).\n* Any medical condition considered by the investigator to contraindicate study participation.",true,"ALL","18 Years","89 Years",{"count":20,"type":21},300,"ESTIMATED","OBSERVATIONAL","This observational study aims to determine whether ultrasound-derived muscle biomarkers can predict isometric quadriceps muscle strength and handgrip in healthy adults aged 18-89 years.\n\nThe main questions it aims to answer are:\n\n* Which ultrasound muscle characteristics are associated with isometric quadriceps muscle strength and handgrip?\n* Can ultrasound-derived biomarkers be used to develop predictive models of muscle strength in healthy adults?\n\nParticipants will undergo:\n\n* Ultrasound assessment of the quadriceps and forearm flexor muscles;\n* Measurement of isometric quadriceps muscle strength and handgrip using standardized dynamometry protocols;\n* Assessment of functional capacity, mobility and balance;\n* Completion of questionnaires related to health status, physical activity, nutrition, fatigue and health-related quality of life.\n\nThe study will also assess the reliability of ultrasound measurements and explore the relationship between ultrasound variables, muscle strength, physical function and health-related factors.",[25,26,27],"Healthy Adult","Muscle Strength","Skeletal Muscle Ultrasound",[29,30,31,32,33,34,35,36,37],"Muscle ultrasound","Skeletal muscle ultrasonography","Muscle biomarkers","Isometric quadriceps muscle strength","Handgrip","Muscle thickness","Echo intensity","Muscle quality","Predictive models","NOT_YET_RECRUITING","2026-06-12",{"date":41,"type":42},"2026-06-16","ACTUAL",{"date":44,"type":21},"2026-06",{"date":46,"type":21},"2029-06",{"name":48,"class":49},"University of Alcala","OTHER",""]