[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"skin-barrier-disruption-and-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:skin-barrier-disruption-and-recovery":64},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644953",false,"NCT07676253","Helichrysum Italicum Extract in Irritant Contact Dermatitis","Assessment of the Effect of Helichrysum Italicum Extract in Irritant Contact Dermatitis: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* healthy volunteers who gave written informed consent\n\nExclusion Criteria:\n\n* skin disease\n* skin damage on measurement sites\n* use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial\n* pregnancy or breastfeeding\n* immunosuppression\n* allergic or irritant reactions to the constituents of the cream",true,"ALL","18 Years","50 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate the efficacy and safety of a topical cream containing Immortelle (Helichrysum italicum) extract in promoting skin barrier recovery and reducing signs of irritant contact dermatitis in healthy adult participants.\n\nThe main questions it aims to answer are:\n\n* Does topical application of Helichrysum italicum extract improve skin barrier recovery following experimentally induced irritant contact dermatitis?\n* Does the cream containing Helichrysum italicum extract reduce transepidermal water loss and erythema, and improve skin hydration compared to a standard moisturizing cream?\n* Is the topical application of Helichrysum italicum extract safe and well tolerated?\n\nResearchers will compare skin sites treated with a cream containing Helichrysum italicum extract, placebo-treated skin sites, and untreated skin sites to determine whether the addition of the extract provides additional benefits in skin barrier recovery.\n\nParticipants will:\n\n* Undergo induction of irritant contact dermatitis using sodium lauryl sulfate (SLS) under occlusion.\n* Apply a cream containing Helichrysum italicum extract to one designated skin site and a placebo cream to another designated skin site twice daily throughout the study period.\n* Have an additional SLS-treated skin site left untreated to assess natural skin barrier recovery.\n* Apply the cream containing Helichrysum italicum extract to a separate area of healthy, intact skin.\n* Attend daily study visits for non-invasive assessments of skin barrier function, including transepidermal water loss, skin hydration, and erythema measurements.",[27],"Skin Barrier Disruption and Recovery",[29,30,31,32],"Helichrysum italicum","Immortelle","Irritant contact dermatitis","Skin barrier recovery","RECRUITING","2026-06-23",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":21},"2026-06",{"date":41,"type":21},"2027-06",{"name":43,"class":44},"University of Split, School of Medicine","OTHER",1,{"id":47,"slug":4,"hasResults":10,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":45},"100641956","NCT07614698","Evaluation of a Peptide Cream on the Forearm Skin Recovery of Healthy Volunteers","Evaluation of the Efficacy of a Topical Formulation Containing Acetyl Hexapeptide-37 on Skin Barrier Recovery of the Forearm After Controlled Damage Using the Tape-stripping Method","Inclusion Criteria:\n\n* healthy volunteers who gave written informed consent\n\nExclusion Criteria:\n\n* skin disease\n* skin damage on measurement sites\n* use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial\n* use of emollients three days prior the inclusion in the trial\n* non-adherence to the trial protocol\n* exposure to artificial and excessive natural ultraviolet (UV) radiation\n* pregnancy or breastfeeding\n* immunosuppression\n* allergic or irritant reactions to the constituents of the cream",{"count":20,"type":21},[24],"The goal of this clinical trial is to evaluate the efficacy of a topical peptide-based formulation containing Acetyl Hexapeptide-37 in promoting skin barrier recovery after controlled disruption in healthy adult participants.\n\nThe main questions it aims to answer are:\n\n* Does the peptide cream speed up the recovery of the skin barrier after it has been slightly damaged with tape-stripping method?\n* How does the peptide cream compare to a placebo (a cream with no active ingredient) in improving skin hydration and reducing redness?\n\nResearchers will compare the peptide cream to a placebo to assess its effects on skin barrier recovery\n\nParticipants will:\n\n* Undergo controlled disruption of the skin barrier on the volar forearm using the tape-stripping method.\n* One forearm will receive the peptide-based cream containing Acetyl Hexapeptide-37, while the other (contralateral) forearm will receive a placebo formulation.\n* Attend scheduled visits for non-invasive assessments of skin barrier function, including transepidermal water loss, skin hydration, and erythema",[27],"2026-06-15",{"date":58,"type":37},"2026-06-17",{"date":60,"type":37},"2026-06-01",{"date":62,"type":21},"2027-01",{"name":43,"class":44},""]