[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spinocerebellar-ataxia-type-27b\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spinocerebellar-ataxia-type-27b":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":14,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100552397",false,"NCT06472557","Spinocerebellar Ataxia Type 27B Natural History Study (SCA27B-NHS)","Inclusion Criteria:\n\n* SCA27B: genetic diagnosis of ≥250 uninterrupted GAA repeat expansions in FGF14\n* SCA27B risk subject: asymptomatic first-degree relative of SCA27B participant with known or unknown carrier status\n* Unrelated healthy controls: no signs or history of neurological or psychiatric disease AND\n* Written informed consent AND\n* Participants are willing and able to comply with study procedures\n\nExclusion Criteria:\n\n* SCA27B: Missing informed consent\n* SCA27B risk subjects: Missing informed consent\n* Unrelated healthy controls: Missing informed consent, or concurrent neurological, orthopedic, or other diseases interfering with the motor assessments",true,"ALL","18 Years","99 Years",{"count":19,"type":20},300,"ESTIMATED","24 Months","OBSERVATIONAL","This international, multi-center, multi-modal, and prospective observational cohort study aims to validate trial outcomes for capturing disease progression in Spinocerebellar Ataxia Type 27B (SCA27B), with combined multi-modal capture of clinical outcome assessments, digital-motor assessments, and molecular biomarkers.",[25],"Spinocerebellar Ataxia Type 27B",[27,28,29,30,31],"ataxia","SCA27B","FGF14","Natural History Study","Outcome Validation","RECRUITING","2026-03-30",{"date":35,"type":36},"2026-04-06","ACTUAL",{"date":38,"type":36},"2024-06-04",{"date":40,"type":20},"2028-12-31",{"name":42,"class":43},"University Hospital Tuebingen","OTHER",5,""]