[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sputum\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sputum":103},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,81],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100619649",false,"NCT07347366","Electromagnetic High-Frequency Chest Wall Oscillation on Pulmonary Mucus Clearance in Patients With Impaired Self-Expectoration","Effects of Electromagnetic High-Frequency Chest Wall Oscillation on Pulmonary Mucus Clearance in Patients With Impaired Self-Expectoration: An Investigator-Initiated, Single-Center, Prospective, Exploratory Study","Inclusion Criteria:\n\n* Hospitalized patients who require sputum clearance.\n* Patients who present with fever or respiratory symptoms (cough, sputum) and, after confirmation of findings on imaging studies, are judged by the clinician to require sputum clearance.\n* Adult patients (≥ 18 years) who have signed the informed consent form, or patients for whom consent has been obtained from a legally authorized representative\n\nExclusion Criteria:\n\n* Patients with severe pneumonia requiring intensive care unit (ICU) treatment.\n* Patients with major pulmonary diseases other than pneumonia, such as active tuberculosis or lung cancer.\n* Patients with severe respiratory failure (PaO₂\u002FFiO₂ ≤ 200 mmHg).\n* Patients with hemodynamically unstable cardiovascular disease (myocardial infarction within the past 3 months, or heart failure of NYHA class 3 or higher).\n* Patients hospitalized for head and neck trauma whose surgical site has not yet healed.\n* Patients with serious cardiac arrhythmias or hemodynamic instability.\n* Patients who have had pneumothorax or massive hemoptysis within the past 6 months, or who currently have hemoptysis.\n* Patients who have undergone spinal surgery within the past 6 months or who have acute spinal injury.\n* Patients with osteoporosis.\n* Patients with bronchopleural fistula.\n* Pregnant or breastfeeding women.\n* Patients diagnosed with cervical disc disease.\n* Individuals who have participated in clinical studies two or more times in the same year, or who have participated in another clinical study within the past 6 months (however, patients enrolled in chronic lung disease cohort studies such as asthma or COPD are allowed).\n* Individuals who, in the judgment of the principal investigator or sub-investigator, have clinically significant findings that make them unsuitable for participation in this study","ALL","18 Years",{"count":18,"type":19},45,"ESTIMATED","INTERVENTIONAL",[22],"NA","This exploratory study aims to evaluate the efficacy and safety of an electromagnetic high-frequency, low-strain chest wall oscillation device for enhancing pulm",[25],"Sputum",[27,28,29,30],"sputum clearance","respiratory symptoms","Pulmonary Mucus Clearance","Electromagnetic High-Frequency Chest Wall Oscillation","RECRUITING","2026-01-08",{"date":34,"type":35},"2026-01-16","ACTUAL",{"date":37,"type":35},"2025-09-23",{"date":39,"type":19},"2026-12-31",{"name":41,"class":42},"Pusan National University Yangsan Hospital","OTHER",1,{"id":45,"slug":4,"hasResults":10,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":51,"targetDuration":53,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":43},"100555017","NCT06506617","HCAPPED I: HCAP-Pcr in Emergency Department","HCAPPED I: HCAP - Pcr in Emergency Department. Early Multiplex PCR on Respiratory Samples From Patients With Pneumonia. A No-profit Observation Prospective Study","HCAPPED-I","Inclusion Criteria:\n\nAll patients over the age of 18 who undergo bronchoalveolar lavage (BAL) in the Emergency Department (DEA), with a Rankin score of less than 5, and who are admitted to the Emergency Department with a diagnosis of healthcare-associated pneumonia (HCAP) of bacterial, viral, or fungal origin. The diagnosis must be confirmed by clinical and radiological criteria according to the IDSA guidelines, which include: New pulmonary infiltrate on chest X-ray, Evidence that the infiltrate is of infectious origin, At least two of the following three clinical signs: Fever higher than 38 °C, Leukocytosis or leukopenia, Purulent secretions.\n\nAdditionally, patients must meet at least one of the following criteria:\n\n* Need for high-flow oxygen therapy (VM35 or FiO2 \\>35%, Reservoir, HFNC, NIV, CPAP)\n* Intubation (IOT)\n* SOFA score ≥2 or PSI score \\>85 (age 75 + IR)\n* Horowitz index (PaO2\u002FFiO2) \\< 200\n\nExclusion Criteria:\n\n* Lack of consent\n* Age under 18 or over 90\n* Pregnancy\n* Life expectancy less than 3 months\n* Hospital admission \\>48 hours (hospital-acquired pneumonia - HAP)\n* Rankin score ≥ 5\n* Community-acquired pneumonia (CAP)",{"count":52,"type":19},93,"90 Days","OBSERVATIONAL","Prospective Observational Study (on Diagnostic Procedure) - Single-Center, Non-Profit.\n\nA pilot study will be conducted on a prospective cohort of patients with HCAP (Healthcare-Associated Pneumonia). This study will be conducted on a single arm of patients. No control group or randomization is planned.\n\nThe use of syndromic molecular panels in pneumonias with risk factors for MDR (multidrug-resistant) pathogens, such as in patients with HCAP, has become common practice. However, the use of this tool is reserved for patients with severe forms of HCAP (PIRO\\>2, at least moderate ARDS, and respiratory failure requiring high-flow oxygen during sepsis) (30), and it is not yet standardized by international guidelines. The decision to use this tool or not is currently at the clinician\\'s discretion and is usually reserved for the severe forms mentioned above. The study aims to determine if the early use of this tool has a real benefit on the management of antibiotic therapy for these patients in terms of therapeutic changes compared to corporate and international guidelines.\n\nDuration of patient enrollment: 1 year. Duration of the study: 1.5 years.",[57,58,59,25],"Pneumonia","Bronchoalveolar Lavage","Antimicrobial Treatment",[61,62,63,64,65,66,67,68,69,70,71],"Bronchoalveolar lavage","Endotracheal Aspirate","Antimicrobial treatment","pneumonia","hcap","pcr multiplex","moleculas syndromic panel","bal","bas","eta","sputum","2024-07-16",{"date":74,"type":35},"2024-07-17",{"date":76,"type":35},"2024-06-07",{"date":78,"type":19},"2026-01-07",{"name":80,"class":42},"Azienda Ospedaliero-Universitaria Careggi",{"id":82,"slug":4,"hasResults":10,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":10,"sex":15,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":20,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":43},"100555124","NCT06508008","Rapid and Safe Sputum Suction Method Validation","Verification of the Effect of Intermittent Negative Pressure Sputum Suction Through Oral Pharyngeal Ventilation Tube in Comatose Patients","Inclusion Criteria:\n\n* 1\\. Clinical diagnosis of stroke; 2. Clinical diagnosis of comatose;\n\nExclusion Criteria:\n\n* 1\\. Clinical diagnosis of multiple organ failure; 2. Clinical diagnosis of multiple organ bleeding;","20 Years","90 Years",{"count":90,"type":19},900,[22],"600 comatose patients admitted to the hospital in China from June 2024 to June 2028 were randomly divided into groups A and B. Group A used intermittent negative pressure suction through oral and pharyngeal ventilation, while group B used continuous negative pressure suction through regular oral and nasal suction.",[25],"2024-07-12",{"date":96,"type":35},"2024-07-18",{"date":98,"type":35},"2024-02-18",{"date":100,"type":19},"2024-08-18",{"name":102,"class":42},"Affiliated Hospital of Nantong University",""]