[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"staphylococcus-aureus-bloodstream-infections-bsi-bacteremia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:staphylococcus-aureus-bloodstream-infections-bsi-bacteremia":95},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,83],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100054119",false,"NCT06958835","Linezolid Plus Standard of Care","Combination Antibiotic Treatment With Linezolid for Staphylococcus Aureus Bacteraemia: a Randomised Controlled Trial","LIPS","Inclusion criteria:\n\n* Staphylococcus aureus (S. aureus) grown from at least one blood culture\n* Hospitalised at a participating centre\n* ≥18 years old\n* Written informed consent or fulfilling criteria for an emergency exception from informed consent requirements\n\nExclusion criteria:\n\n* Administration of the initial drug treatment not feasible within 72 hours since the collection of the first positive blood culture with S. aureus\n* Documented history of positive blood cultures for S. aureus occurring between 72 hours and 180 days prior to the eligibility assessment\n* Necrotising fasciitis\n* Currently receiving linezolid or clindamycin\n* Use of any monoamine oxidase A or B inhibitor within the last two weeks\n* Known hypersensitivity to linezolid or any other ingredients of the study drugs\n* Current severe thrombocytopenia (i.e. \\\u003C30 x 10\\^9\u002FL)\n* Application of study drug not possible (per mouth or per gastric tube)\n* Currently breastfeeding\n* Local treating team believes that death is imminent and inevitable\n* Patient is receiving end of life care and antibiotic treatment is not considered appropriate\n* Local treating team believes that participation in the study is not in the best interest of the patient\n* Any indication that the patient is unwilling to participate in the study including an advance directive stating such unwillingness","ALL","18 Years",{"count":19,"type":20},606,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with Staphylococcus aureus bacteraemia.",[26],"Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)",[28,29,30,31,32,33,34,35,36,37],"Virulence factors","Linezolid","Bloodstream Infection","Hierarchical composite endpoint","Staphylococcus aureus","Bacteremia","Bacteraemia","Methicillin-resistant Staphylococcus aureus (MRSA)","Penicillin-susceptible Staphylococcus aureus (PSSA)","Methicillin-susceptible Staphylococcus aureus (MSSA)","RECRUITING","2026-07-09",{"date":41,"type":42},"2026-07-13","ACTUAL",{"date":44,"type":42},"2025-10-06",{"date":46,"type":20},"2028-10",{"name":48,"class":49},"University Hospital, Basel, Switzerland","OTHER",12,{"id":52,"slug":4,"hasResults":10,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100571910","NCT06726395","Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia","Randomized Controlled Clinical Trial Comparing Treatment With Cloxacillin Versus Benzylpenicillin in Bacteraemia Caused by Penicillin-susceptible Staphylococcus Aureus (PSSA)","COMeBAC","Inclusion Criteria:\n\nAged ≥18 with penicillin susceptible S. aureus bacteraemia (PSSA), and able to provide written informed consent.\n\nExclusion Criteria:\n\n* allergy to penicillin,\n* inability to give informed consent,\n* concomitant growth of other clinically significant bacteria in blood cultures\n* neutropenia\n\n  -≥ 96h with prior antibiotics\n* When the per oral follow up medication can not be flukloxacillin or penicillinV\u002FAmoxicillin (ie prosthetic joint infection)\n* Patients in terminal palliation, where death is expected within 7 days.\n* Where the treating physician believes cloxacillin is not a first-line treatment.",{"count":59,"type":20},420,[61],"PHASE4","The goal of this study is to investigate if benzylpenicillin is a better treatment option than cloxacillin in patients with penicillin-susceptible Staphylococcus aureus bacteraemia.",[64,65,26,66],"Staphylococcus Aureus Bacteraemia","Staphylococcal Bacteraemia","Staphylococcus (S.) Aureus Infection",[68,69,70,71,72],"Penicillin treatment","benzylpenicillin","cloxacillin","Penicillin susceptible S. aureus","Staphylococcus aureus bacteraemia","2026-04-24",{"date":75,"type":42},"2026-04-30",{"date":77,"type":42},"2025-03-10",{"date":79,"type":20},"2028-07",{"name":81,"class":49},"Region Skane",1,{"id":84,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":24,"conditions":87,"keywords":88,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":93,"leadSponsor":94,"locationsCount":50},"100589778",{"count":19,"type":20},[23],[26],[28,29,30,31,32,33,34,35,36,37],"2026-03-19",{"date":91,"type":42},"2026-03-24",{"date":44,"type":42},{"date":46,"type":20},{"name":48,"class":49},""]