[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sucrose-intolerance-due-to-sucrase-isomaltase-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sucrose-intolerance-due-to-sucrase-isomaltase-deficiency":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100451485",false,"NCT05159115","Sucrase-isomaltase Deficiency as a Cause of Irritable Bowel Syndrome","Validation of the 13C-labelled breath test to diagnose sucrase-isomaltase deficiency (n=40)\n\nInclusion Criteria:\n\n* Signed informed consent\n* BMI 18-30 kg\u002Fm2\n* Referred for gastroscopic examination with suspected GI disorder\n\nExclusion Criteria:\n\n• Unwilling or not capable of signing the informed consent\n\nSucrase-isomaltase deficiency as a cause of symptoms in patients with irritable bowel syndrome (n=80)\n\nInclusion Criteria:\n\n* Signed informed consent\n* BMI 18-30 kg\u002Fm2\n* IBS diagnosis according to Rome IV criteria\n\nExclusion Criteria:\n\n* Inflammatory bowel disease, celiac disease or diabetes mellitus\n* Chronic immune diseases affecting the GI-system\n* Unwilling\u002Funable to maintain a stable diet throughout the study period\n* Use of antibiotic treatment for the last 4 weeks\n* Currently on a restrictive diet","ALL","18 Years","90 Years",{"count":18,"type":19},80,"ESTIMATED","INTERVENTIONAL",[22],"NA","Irritable bowel syndrome (IBS) is a functional disorder causing troublesome symptoms and reduced quality of life. It affects 10-20% of the population, hence creates large costs for society. About 30-40% of all IBS patients do not benefit from current treatment options. Sucrase-isomaltase (SI) deficiency is an unexplored condition, that may explain symptoms in IBS patients who experience no effect from today's treatments. Currently, a duodenal biopsy is the gold standard for the diagnosis of SI deficiency, however the condition is not well investigated. A 13C-labelled breath test holds promise as a non-invasive alternative, but it has not previously been validated.\n\nThis project will address the knowledge gap related to a possible association between SI deficiency and IBS by addressing two research questions that have never been answered before. We aim to:\n\n1. Validate the 13C-labelled breath test as a diagnostic tool by assessing the strength of the association between the breath test and SI activity measured in duodenal biopsies\n2. Use the 13C-labelled breath test in a randomized dietary crossover trial comparing a starch and sucrose reduced diet (SSRD) with the standard low-FODMAP diet in IBS patients, to evaluate whether SI activity is associated with dietary changes according to symptom severity and gut microbiota composition",[25,26,27,28,29],"Irritable Bowel Syndrome","Sucrose Intolerance Due to Sucrase-Isomaltase Deficiency","Carbohydrate; Malabsorption","Sucrase Isomaltase Deficiency","Functional Gastrointestinal Disorders","NOT_YET_RECRUITING","2022-01-18",{"date":33,"type":34},"2022-02-02","ACTUAL",{"date":36,"type":19},"2022-03-14",{"date":38,"type":19},"2027-12-31",{"name":40,"class":41},"Lovisenberg Diakonale Hospital","OTHER",""]