[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"surgical-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:surgical-injury":99},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,81],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100396242",false,"NCT04439552","fMRI and IVCM Cornea Microscopy of CXL in Keratoconus","Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus","Inclusion Criteria:\n\nCXL Group\n\n* Age 8-35 years\n* Clinical diagnosis of keratoconus and seeking CXL treatment\n* English speaking ability sufficient to comprehend consent with parental assistance\n* MRI compatible\n* Ability to lie still for an MRI session (60 minutes)\n\nControl Group\n\n* Age 8-35 years\n* No diagnosis of keratoconus\n* English speaking ability sufficient to comprehend consent with parental assistance\n* MRI compatible\n* Ability to lie still for an MRI session (60 minutes)\n\nExclusion Criteria (Both Groups):\n\n* Claustrophobic\n* Weight \\> 285 lbs (weight limit of the MRI table)\n* Significant medical history, including:\n\nCurrent DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes\n\n* Magnetic implants or metal-containing tattoos on their chest or above\n* Pregnancy\n* History of contact lens wear\n* Any allergic response to a numbing eyedrop in the past",true,"ALL","8 Years","35 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).",[25,26,27,28,29,30,31,32],"Pain, Postoperative","Pain, Chronic","Pain, Acute","Surgical Injury","Surgical Wound","Cornea Injury","Cornea","Keratoconus",[34,35,36,37],"fMRI","Corneal Microscopy","IVCM","Neuroimaging","RECRUITING","2025-12-15",{"date":41,"type":42},"2025-12-19","ACTUAL",{"date":44,"type":42},"2021-10-04",{"date":46,"type":21},"2027-12",{"name":48,"class":49},"Boston Children's Hospital","OTHER",1,{"id":52,"slug":4,"hasResults":10,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":10,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100581987","NCT06857448","Autologous Point-of-Care Adipose Therapy: Recent Injury","Autologous Point-of-Care Adipose Therapy for Reconstruction and Regeneration of Traumatized Skin: Recent Injury","Inclusion Criteria:\n\n* The proposed study will include adult patients 18 years of age or older,\n* male or female,\n* civilian, military, active duty or retired veterans\n* presenting for unilateral or bilateral fasciotomy of the extremity at any level necessary\n* secondary to non-infectious etiology,\n* unilateral or bilateral traumatic full-thickness skin loss of the face, head, neck or extremities necessitating reconstruction, and\u002For\n* full or partial thickness burn injury of the face, neck, or extremity requiring excision and\u002For reconstruction.\n* Additional inclusion criteria includes willingness to be randomized to receive a fat graft.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years of age,\n* active infection,\n* medical co-morbidities or anatomic configuration deemed by the physician to be a concern for safety,\n* unwilling or unable to comply with study procedures,\n* radiation to the site of interest,\n* prisoners and\u002For vulnerable populations.\n* In addition, candidates that are pregnant or plan to become pregnant in the next year, will be excluded.","18 Years",{"count":59,"type":21},68,"INTERVENTIONAL",[62],"NA","The goal of this study is to explore if an adipose-based therapeutic strategy can treat full-thickness soft-tissue trauma wounds in injured individuals, especially those with severe burns or soft-tissue loss. The main question it aims to answer are:\n\n\\- Can immediate autologous adipose and autologous layered composite grafting be effective for acute functional soft-tissue reconstruction?\n\nResearchers will compare the single-stage autologous layered composite grafting method to traditional methods to see if it improves healing outcomes, minimizes scarring, and reduces infection risk.\n\nParticipants will:\n\n* Receive immediate fat grafting into the wound.\n* Undergo simultaneous split-thickness skin grafting for full soft-tissue reconstruction.",[65,66,28],"Burns","Contracture Scar",[68,69],"fasciotomy","trauma","NOT_YET_RECRUITING","2025-11-03",{"date":73,"type":42},"2025-11-05",{"date":75,"type":21},"2025-12",{"date":77,"type":21},"2028-10-30",{"name":79,"class":49},"University of Pittsburgh",2,{"id":82,"slug":4,"hasResults":10,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":10,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":60,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":98,"locationsCount":80},"100581986","NCT06857435","Autologous Point-of-Care Adipose Therapy: Delayed Injury\u002FScar","Autologous Point-of-Care Adipose Therapy for Reconstruction and Regeneration of Traumatized Skin: Delayed Injury\u002FScar","Inclusion Criteria:\n\n* The proposed study will include adult patients 18 years of age or older,\n* male or female,\n* civilian, military, active duty or retired veterans\n* presenting for scar contracture release and reconstruction at any level.\n* Additional inclusion criteria includes willingness to be randomized to receive a fat graft.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years of age,\n* active infection,\n* medical co-morbidities or anatomic configuration deemed by the physician to be a concern for safety,\n* unwilling or unable to comply with study procedures,\n* radiation to the site of interest,\n* prisoners and\u002For vulnerable populations.\n* In addition, candidates that are pregnant or plan to become pregnant in the next year, will be excluded.",{"count":88,"type":21},40,[62],"The goal of this study is to explore if an adipose-based therapeutic strategy can treat contracted scars secondary to soft-tissue burn wounds in injured individuals, especially those with severe burns or soft-tissue loss. The main question it aims to answer are:\n\n\\- Can autologous layered composite grafting demonstrate non-inferiority compared to full-thickness skin grafting for delayed reconstruction of post-burn or trauma scar contracture?\n\nResearchers will compare the single-stage autologous layered composite grafting method to traditional methods to see if it improves healing outcomes, minimizes scarring, and reduces infection risk.\n\nParticipants will:\n\n* Receive fat grafting at time of scar revision.\n* Undergo simultaneous split-thickness skin grafting for full soft-tissue reconstruction.",[65,66,28],[93,94],"burns","scar contracture",{"date":73,"type":42},{"date":75,"type":21},{"date":77,"type":21},{"name":79,"class":49},""]