[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"symptomatic-apical-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:symptomatic-apical-periodontitis":74},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100637854",false,"NCT07585721","Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis","Clinical Evaluation of the Postoperative Pain and Substance P Levels Following the Use of Bioceramic Verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular Molars With Symptomatic Apical Periodontitis","(BCvsCaOH)","Inclusion Criteria:\n\n* \\- Patients aged 18-45 years with no sex predilection\n* Medically free Patients with no systemic conditions that can affect post operative pain response.\n* Patients should not be taking any pain medications 24 hours before intervention\n* Positive patients' acceptance for participating in the study\n* Patient able to sign informed consent\n* Permanent mandibular molars diagnosis with Symptomatic Apical Periodontitis\n* Permanent molars without any anatomical variations or severe curvatures\n\nExclusion Criteria:\n\n* \\- Medically compromised patients\n* Patients who have received antibiotic therapy within the last 2 weeks.\n* Pregnant or lactating women.\n* Patients with known allergy to any of the irrigants used.\n* Patients with swelling or acute peri-apical abscess or fistulous tract.\n* Teeth that have:\n* Wide or open apex .\n* Vital pulp tissue .\n* Periodontally affected with grade 2or 3 mobility.\n* Non restorable teeth .\n* Abnormal anatomy and calcified canals .\n* Pervious root canal treatment.\n* severe curved canal\n* Buccolingual and mesiodistal radiographs were taken to evaluate the root canal anatomy",true,"ALL","18 Years","45 Years",{"count":21,"type":22},28,"ESTIMATED","INTERVENTIONAL",[25],"NA","Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis",[28],"Symptomatic Apical Periodontitis",[30,31,32,33,34,35,36,37,38,39,28],"Postoperative Pain","Substance P","Calcium Hydroxide","Bioceramic intra-canal medication","BIO-C TEMP","Mandibular Molars","Intra canal medication","Endodontics","Root Canal Treatment","inflammatory mediators","NOT_YET_RECRUITING","2026-05-10",{"date":43,"type":44},"2026-05-14","ACTUAL",{"date":46,"type":22},"2026-06-01",{"date":48,"type":22},"2027-02-01",{"name":50,"class":51},"Future University in Egypt","OTHER",{"id":53,"slug":4,"hasResults":10,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100614608","NCT07281807","Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars","Inclusion Criteria:\n\n* Healthy patient ranging between 18-40 years\n* Having at least one premolar with diagnosis of symptomatic irreversible pulpitis according to history, examination and radiographs.\n* Teeth having mature apex confirmed by periapical radiographs.\n\nExclusion Criteria:\n\n* History of systemic disorders including HIV, Hepatitis\n\n  * Pregnancy (As per Medical record\u002F Verbally)\n  * Patient using medication such as analgesics or anti-inflammatory drugs\n  * Patient allergic to lignocaine, piroxicam and prednisolone\n  * Tooth not suitable for restoration\n  * Periodontal probing depth ≥ 4mm\n  * Retreatment cases\n  * Patients having calcified canals assessed by radiographic findings","40 Years",{"count":59,"type":22},60,[61],"PHASE4","To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.",[64,28],"Irreversible Pulpitis With Apical Periodontitis","2025-12-02",{"date":67,"type":44},"2025-12-15",{"date":69,"type":22},"2026-01-01",{"date":71,"type":22},"2027-01-31",{"name":73,"class":51},"RANA AHMAD",""]