[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"temporomandibular-joint-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:temporomandibular-joint-disorders":642},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,42,64,100,124,149,174,191,219,239,266,295,318,367,386,413,436,456,476,501,530,551,571,593,619],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100521512",false,"NCT06070558","ChAracterization of Normal and Pathological moRphological Variations of the TEMporomandibular Joint by Real-time magnetIc reSonance Imaging","ARTEMIS","Inclusion Criteria:\n\n* Adult: age ≥ 18 years old;\n* Person with the capacity to understand the instructions given;\n* Person affiliated to a social security scheme or beneficiary of such a scheme;\n* Person having received complete information on the organization of the Clinical Investigation and having signed informed consent.\n\nExclusion Criteria:\n\n* Person with large-scale metallic dental reconstructions;\n* Edentulism more than 5 teeth;\n* Claustrophobia;\n* Contraindication to performing an MRI examination\n* Persons referred to in Articles 64, 65 and 66 of European Regulation 2017\u002F745 on Medical Devices (RDM) and in L. 1121-5 to L1121-8 of the French Public Health Code",true,"ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","The Real Time MRI Rapid Flash sequence is particularly interesting for the study of moving organs and joints.\n\nThis sequence will make it possible to characterize normal and pathological temporomandibular joint movements by MRI.",[27,28],"Healthy","Temporomandibular Joint Disorders","RECRUITING","2026-06-16",{"date":32,"type":33},"2026-06-17","ACTUAL",{"date":35,"type":33},"2023-12-12",{"date":37,"type":21},"2026-12-12",{"name":39,"class":40},"Central Hospital, Nancy, France","OTHER",1,{"id":43,"slug":4,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":41},"100620554","NCT07359131","Postoperative Assessment of Platelet-Rich Plasma and Platelet-Rich Fibrin in Temporomandibular Joint Surgery","Postoperative Assessment in TMJ Surgery: A Comparison of the Efficacy of Intraoperative Platelet-Rich Plasma and Platelet-Rich Fibrin Injections","Inclusion Criteria:\n\nPatients aged 18 to 75 years (inclusive)\n\nUnderwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy\n\nReceived intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy\n\nExclusion Criteria:\n\nAge younger than 18 years or older than 75 years\n\nDid not undergo TMJ arthroscopy\n\nDid not receive intraoperative PRP or PRF injection\n\nIncomplete clinical or follow-up data","75 Years",{"count":50,"type":21},700,"OBSERVATIONAL","The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders.\n\nThe study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are:\n\nWhether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery.\n\nWhether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms.\n\nIf there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms.\n\nParticipants will:\n\nHave their existing medical records reviewed retrospectively.\n\nProvide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.",[28],"NOT_YET_RECRUITING","2026-06-06",{"date":57,"type":33},"2026-06-09",{"date":59,"type":21},"2026-11-15",{"date":61,"type":21},"2027-12-05",{"name":63,"class":40},"Jingping Wang, MD, Ph.D.",{"id":65,"slug":4,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":74,"briefSummary":75,"conditions":76,"keywords":81,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100638786","NCT07584642","Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD Pain","A Prospective, Single-Arm, Open-Label Pilot Clinical Study to Evaluate Efficacy and Safety of Nighttime Occlusive 10% 35 kDa Hyaluronan (HA35) Gel for Temporomandibular Joint Disorder (TMD) Pain and Muscle Over-Tension","HA35-TMJ","Inclusion Criteria:\n\n* Age 18-60 years, male or female\n* Clinically diagnosed with TMD with TMJ pain and\u002For muscle over-tension\n* Baseline TMJ pain NRS score ≥3\n* History of bruxism or jaw clenching\n* Ability to complete NRS assessments independently\n* Signed written informed consent\n\nExclusion Criteria:\n\n* TMJ treatment (medication, physical therapy, injection) within 2 weeks\n* Topical analgesic\u002Fanti-inflammatory use within 24 hours\n* Skin damage, allergy, or infection in the TMJ application area\n* Severe systemic disease (cardiovascular, diabetes, autoimmune)\n* Known hypersensitivity to hyaluronan or gel components\n* Pregnant or lactating women","60 Years",{"count":73,"type":21},30,[24],"This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nighttime occlusive application of 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with temporomandibular joint disorder (TMD). Eligible participants will apply HA35 gel to the TMJ area nightly under occlusive conditions for 8-12 hours. The primary objectives are to assess rapid pain relief and muscle over-tension reduction at 60 seconds and 12 hours after application. Safety and local tolerability will be evaluated throughout the study period. This is a minimal-risk, non-pharmacological, non-invasive intervention.",[28,77,78,79,80],"TMD","Temporomandibular Joint Pain","Jaw Muscle Over-Tension","Bruxism",[82,83,84,85,77,78,86,87,88,89],"Hyaluronan","35 kDa Hyaluronan","Nighttime Occlusive","TMJ","Muscle Over-Tension","Analgesia","Non-invasive Treatment","Pilot Clinical Study","2026-05-07",{"date":92,"type":33},"2026-05-13",{"date":94,"type":21},"2026-05-20",{"date":96,"type":21},"2026-07-20",{"name":98,"class":99},"Nakhia Impex LLC","INDUSTRY",{"id":101,"slug":4,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":123},"100460197","NCT05272488","A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders","A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation Versus a Treatment of Manual Therapy Isolated in Patients With Myogenic Temporomandibular Disorders","Inclusion Criteria:\n\n* Clinical diagnosis of myogenic pain according to the CD \u002F TTM diagnostic criteria.\n* Presence of pain during the last 30 days.\n* Patients with decreased jaw function and mobility due to pain.\n* Patients who have not received physiotherapy treatment in the last 3 weeks.\n* Patients of legal age.\n\nExclusion Criteria:\n\n* Patients with drug treatment: sedatives, anti-inflammatories, antidepressants, anxiolytics or muscle relaxants.\n* Patients with cardiac pacemakers and implanted defibrillators. Patients diagnosed with severe cardiorespiratory and \u002F or respiratory diseases, carcinogenic processes, infectious processes and \u002F or systemic pathologies.\n* Clinical diagnosis of temporomandibular disorder of joint or mixed origin according to the Diagnostic Criteria for Temporomandibular Disorders (CD \u002F TMD).\n* Patients with psychiatric or psychological disorders, intellectual or motor deficiencies that, due to their nature, prevent them from correctly performing the prescribed exercises, correctly following the physiotherapist's instructions or understanding the questionnaires and \u002F or measurement scales of the variables.\n* Patients with dental processes scheduled during the study period or who have undergone surgery in the last 3 months.\n* Patients with suspicion or certainty that their pain has appeared as a consequence of a local or general trauma.\n* Patients diagnosed with fibromyalgia, neuropathic pain or degenerative diseases",{"count":20,"type":21},[24],"Temporomandibular disorders (TMD) are one of the most important Public Health issues in the world and its incidence has increased over the years. The Physiotherapy and manual therapy techniques has shown its efficacy to reduce pain and to improve jaw functionality in patients with TMD. Until now, treatment targets has been the muscle and joint, but clinicians has not taken into account the innervation and how the nerve can have an influence in pain or jaw functionality.\n\nIn this sense, it is known that there is a relationship between jaw innervation and vagus nerve, a parasympathetic nerve which is easily stimulable, due to its connection with the respiratory system, taking deep breaths using the diaphragm.\n\nTherefore, our hypothesis is that a treatment in which clinicians combine manual therapy and nerve vagus stimulation could have better effects (reducing pain, increasing range of motion in temporomandibular joints and improving quality of life in patients with TMD) than a isolated manual therapy treatment.\n\nWith this purpose will be selected 20 subjects to participate in our study divided in two groups. Both groups will received 4 sessions of physiotherapy (one each 7 days during one month) and also will be thought to do own treatment those days the subjects does not come to the clinic until the study will have finished (the interventional period last two months). Both groups will received the same manual therapy techniques but only the experimental group will be treated with nerve vagus stimulation technique.\n\nOne member of the group who will not participated in the interventions will be in charge of do evaluations (1 each month\u002F a total of 3 evaluations) following different questionaries to assess the primary variables of the study: chronic pain level, jaw functionality, physical symptoms level, range of motion and distress level.",[28,110],"Pain",[112,113],"Temporomandibular Joint","Manual therapy","2026-04-27",{"date":116,"type":33},"2026-05-01",{"date":118,"type":33},"2022-08-01",{"date":120,"type":21},"2027-09-15",{"name":122,"class":40},"University of Alcala",3,{"id":125,"slug":4,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":132,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":41},"100508962","NCT05907239","Effects of Focal Extracorporeal Shock Wave Therapy in the Treatment of Temporomandibular Disorders of Muscular Origin","Effects of Focal Extracorporeal Shock Wave Therapy in the Treatment of Temporomandibular Disorders of Muscular Origin: a Randomized, Double-blind, Controlled Clinical Trial","Inclusion Criteria:\n\n* Pain in the temporomandibular region;\n* Myofascial pain diagnosed with or without limitation of mouth opening based on the Diagnostic Criteria for TMD (DC\u002FTMD);\n* Myofascial pain associated or not with joint abnormalities;\n* Presence of moderate to severe pain: Visual Analogue Scale (VAS) \\>4;\n* Duration of TMD pain (temporomandibular musculoskeletal) ≥3 months;\n* Written granting of the informed consent form to participate in the study\n\nExclusion Criteria:\n\n* Abnormality in blood clotting (coagulopathy) or using some type of anticoagulant;\n* Primary malignant disease (tumors) in the treatment area;\n* Acute infection of soft tissue or bone;\n* Systemic infections;\n* Epilepsy;\n* Infiltration of corticosteroids at the application site in the last 6 weeks;\n* Patient at high risk of some type of anesthesia or analgesia when it eventually has to be used;\n* Polyarthritis;\n* Polytrauma Local joint infections;\n* Previous temporomandibular surgical treatments that compromise mastication;\n* Treatment by physiotherapy, acupuncture before 3 months of performing the procedures\n* Depression or other mental disorders;\n* Clinical diagnosis of associated fibromyalgia;\n* Associated systemic inflammatory rheumatic diseases;\n* Widespread pain or pain elsewhere that predominates and overlaps with TMD muscle pain;\n* Inability to understand the treatment protocol.",{"count":131,"type":21},100,[24],"The objective of the study is to evaluate the effectiveness of extracorporeal shock wave therapy (ESWT) in improving pain in patients with TMD pain after 5 weeks of treatment, 1 month and 3 months after the end of treatment. As secondary objectives, we plan to evaluate the effectiveness of focal shockwave therapy in relation to:\n\n1. Range of motion (ROM) of the temporomandibular joint using goniometry after 5 weeks of treatment;\n2. Degree of inflammation, using ultrasound evaluation in the temporomandibular joint relating to the degree of pain after focal shockwave therapy for 5 weeks;\n3. Jaw movement (MM), joint noise (RA), joint pressure (PA) and disability index (DI) will be measured at each treatment session and after 5 weeks of treatment, 1 month and 3 months after the end of treatment in the affected joints;\n4. Quality of life will be assessed using the \"Short Form Health 36\" questionnaire (SF-36) during the 5 weeks of treatment, 1 month and 3 months after the end of treatment;\n5. Pain control medication will also be considered and compared before and after the proposed treatment for 5 weeks.\n\nSafety will be assessed throughout the study by monitoring the incidence of study-related adverse events. All patients will be contacted periodically and encouraged to report any side effects.",[28,135],"Extracorporeal Shockwave Therapy",[28,135,137,138,139],"Temporomandibular Joint Dysfunction Syndrome","High-Energy Shock Waves","Pain Management","2026-03-20",{"date":142,"type":33},"2026-03-25",{"date":144,"type":33},"2023-04-20",{"date":146,"type":21},"2029-06-25",{"name":148,"class":40},"University of Sao Paulo General Hospital",{"id":150,"slug":4,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":157,"conditions":158,"keywords":162,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":41},"100628327","NCT07460193","CBCT and Audiological Analysis of the TMJ-Tinnitus Relationship","Investigation of the Interaction Between Temporomandibular Joint and Tinnitus Using CBCT and Audiological Methods: A Prospective Cross-Sectional Study","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Patients presenting with otological symptoms such as tinnitus and ear pain.\n* Patients diagnosed with Temporomandibular Disorders (TMD) based on clinical and radiographic examination.\n* Patients who have been referred for CBCT imaging as part of their routine diagnostic process for TMD.\n* Willingness to provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Presence of objective tinnitus (e.g., vascular or muscular origin).\n* History of chronic otitis media or other middle ear pathologies that could cause hearing loss or tinnitus.\n* Previous history of temporomandibular joint surgery or major maxillofacial trauma.\n* Presence of systemic metabolic bone diseases or inflammatory rheumatic diseases (e.g., Rheumatoid Arthritis).\n* History of malignancy in the head and neck region.\n* Pregnancy (due to CBCT imaging contraindication).\n* Neurological or psychological disorders that would prevent cooperation during clinical and audiological examinations.",{"count":156,"type":21},50,"The aim of this study is to investigate the relationship between Temporomandibular Disorders (TMD) and subjective tinnitus at both morphological and functional levels. Current literature suggests that somatosensory inputs from the temporomandibular joint (TMJ) and masticatory muscles can modulate auditory pathways, a phenomenon known as Somatosensory Tinnitus. However, the specific role of TMJ bone morphology and critical neighboring structures, such as the Petrotympanic Fissure (PTF), in this interaction remains unclear.\n\nIn this clinical study, patients with tinnitus will undergo a comprehensive evaluation including Cone Beam Computed Tomography (CBCT) to quantitatively analyze condylar morphology and osteoarthritic changes. Additionally, audiological tests will be performed to assess the functional state of the auditory system. This multidisciplinary approach aims to clarify the biological link between TMD and tinnitus, potentially improving diagnostic protocols and highlighting the importance of TMJ stabilization in tinnitus management.",[159,28,160,161],"Tinnitus","Somatosensory Tinnitus","Osteoarthritis, Temporomandibular Joint",[159,28,163,164],"Cone-Beam Computed Tomography","Audiometry","2026-03-04",{"date":167,"type":33},"2026-03-10",{"date":169,"type":21},"2026-04-01",{"date":171,"type":21},"2026-07-01",{"name":173,"class":40},"Kutahya Health Sciences University",{"id":175,"slug":4,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":41},"100627483","NCT07449221","Cross Cultural Adaptation, Reliability &Validity of The Arabic Version of 8_Item Jaw Functional Limitation Scale In Temporomandibular Joint Disorders","Inclusion Criteria:\n\n* Patients aged 18 to 65 years .\n* Diagnosis of temporomandibular disorders ) jaw pain-popping sounds in the jaw -limited jaw movements - orofacial pain ) for one month at least, not receiving actual treatment for the orofacial region (splinting)\n* Being conscious and oriented.\n* Able to read and write in Arabic.\n* Both Genders were included.\n\nExclusion Criteria:\n\n* History of trauma (recent head or neck or TMJ severe trauma)\n* Recent surgery at the neck, head or TMJ\n* Diagnosed systemic and psychiatric diseases; diseases that may affect the TMJ, such as ankylosing spondylitis or rheumatoid arthritis; and pregnancy","65 Years",{"count":131,"type":21},"The purpose of this study is to test if the translated Arabic version of the (jaw functional limitation scale -8) JFLS\\_8 , valid (face, content, feasibility) ,reliable (internal consistency, test retest) and culturally adapted enough to quantify the impact of temporomandibular joint (TMJ) disorders on jow function in arabic people or not?",[28],"2026-02-27",{"date":165,"type":33},{"date":186,"type":21},"2026-03-07",{"date":188,"type":21},"2026-05-15",{"name":190,"class":40},"Cairo University",{"id":192,"slug":4,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":197,"targetDuration":199,"studyType":51,"phases":4,"briefSummary":200,"conditions":201,"keywords":202,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":218},"100361866","NCT03991728","Alloplastic Total Temporomandibular Joint (TMJ) Replacement Registry","International, Multicenter, Prospective Registry to Collect Data of Patients Treated With Alloplastic Total Temporomandibular Joint (TMJ) Replacements","Inclusion Criteria:\n\n* Age 18 years and or older\n* Patients requiring alloplastic total TMJ replacement\n* Informed consent obtained, i.e.:\n\n  * Ability to understand the content of the patient information\u002Finformed consent form (ICF)\n  * Willingness and ability to participate in the registry according to the Registry Plan (RP)\n  * Signed and dated ethics committee (EC) \u002F Institutional review board (IRB) approved written informed consent\n\nExclusion Criteria:\n\n* Recent history of substance abuse (i.e. recreational drugs, alcohol) that would preclude reliable assessment\n* Pregnancy or women planning to conceive within the study period\n* Participation in any other medical device or medicinal product study within the previous month that could influence the results of the present study",{"count":198,"type":21},200,"5 Years","Prospective data will be collected in approximately 200 patients treated with an TMJ replacement. Patients will be followed up according to the standard (routine) for up to 5 years after the treatment. Data collection will include underlying disease, treatment details, functional and patient reported outcomes (PRO)s and anticipated or procedure-related adverse events (i.e. complications).\n\nThis registry is designed to be able to assess the number of patients who refuse alloplastic total TMJ replacement. Therefore, the participating sites are asked to register all cases of refused TMJ replacements too.",[28],[203,204,205,206,207,208],"Temporomandibular joint","TMJ replacement","Trauma","Ankylosis","Degenerative joint disease","Registry","2026-02-17",{"date":211,"type":33},"2026-02-18",{"date":213,"type":33},"2019-10-15",{"date":215,"type":21},"2033-12",{"name":217,"class":40},"AO Innovation Translation Center",23,{"id":220,"slug":4,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":226,"targetDuration":4,"studyType":22,"phases":228,"briefSummary":229,"conditions":230,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":237,"locationsCount":41},"100617357","NCT07317570","The Effect of Body Awareness Therapy on Pain, Function and Psychosocial Parameters in Temporomandibular Joint Disorders","A Randomized, Single-Blind Controlled Trial Investigating the Effect of Body Awareness Therapy on Pain, Functional Outcomes, and Psychosocial Parameters in Adults With Temporomandibular Joint Disorders","BAT-TMJ","Inclusion Criteria:\n\nAdults aged 18-65 years. Diagnosed with Temporomandibular Joint Disorders (TMD) according to the Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD).\n\nExperiencing orofacial pain or jaw functional limitation for at least the past 3 months.\n\nAbility to understand and follow verbal instructions required for Body Awareness Therapy sessions.\n\nWillingness to participate in the study and to attend all assessment and intervention sessions.\n\nProviding written informed consent.\n\nExclusion Criteria:\n\nHistory of jaw trauma, fracture, or surgery within the past 6 months. Presence of systemic rheumatologic or inflammatory disorders (e.g., rheumatoid arthritis, ankylosing spondylitis) that may affect TMJ function.\n\nNeurological or psychiatric conditions that could interfere with participation or outcome assessments (e.g., major psychiatric disorder, cognitive impairment).\n\nSevere dental or orthodontic conditions requiring immediate treatment (e.g., acute infection, ongoing orthodontic procedures).\n\nUse of occlusal splints, bite guards, or other TMJ-related interventions initiated within the past 3 months.\n\nParticipation in any other physiotherapy or exercise program targeting the jaw, cervical spine, or posture during the study period.\n\nPregnancy, due to potential changes in joint laxity and pain perception. Current use of medications affecting neuromuscular or pain responses, such as muscle relaxants, corticosteroids, or neuropathic pain medications (unless dose has been stable for 3 months).\n\nAny contraindication to performing light-to-moderate physical activity or awareness-based exercises.\n\nInability to attend scheduled therapy sessions or complete study assessments.",{"count":227,"type":21},52,[24],"This randomized, single-blind controlled trial aims to investigate the effectiveness of Body Awareness Therapy (BAT) on pain, functional limitations, and psychosocial outcomes in individuals with temporomandibular joint disorders (TMD). TMD is characterized by orofacial pain, impaired jaw function, and increased psychosocial burden, yet current physiotherapy approaches may not fully address the biopsychosocial mechanisms underlying these symptoms. BAT is a structured mind-body physiotherapy intervention designed to improve postural awareness, interoceptive sensitivity, breathing regulation, and movement control.\n\nIn this study, participants will be randomly assigned to either BAT or a standard physiotherapy control intervention for a defined treatment period. Primary outcomes will include pain intensity and jaw functional limitations, while secondary outcomes will assess body awareness, anxiety, stress, and quality of life. Evaluations will be conducted at baseline and post-intervention. The findings of this trial may provide evidence for integrating biopsychosocial and awareness-based physiotherapy into TMD rehabilitation.",[28],"2026-01-31",{"date":233,"type":33},"2026-02-03",{"date":235,"type":33},"2025-12-20",{"date":94,"type":21},{"name":238,"class":40},"Recep Tayyip Erdogan University",{"id":240,"slug":4,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":16,"sex":17,"minAge":245,"maxAge":179,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":247,"briefSummary":248,"conditions":249,"keywords":250,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":4},"100615795","NCT07297251","Temporomandibular Joints Mobility and Head Posture: Influence of Manual Therapy and Exercises in Dental Patients.","Assessment of Temporomandibular Joint Mobility With Different Head Postures. Analysis of the Influence of Selected Manual Therapy Techniques on Temporomandibular Joint Mobility and Head Posture.","Inclusion Criteria:\n\n* Patients aged 11 to 13 years with a confirmed occlusion class (Class I, II, or III) with parental\u002Flegal guardian consent.\n* Patients aged 13 to 17 years with personal assent and parental\u002Flegal guardian consent.\n* Adult patients (up to 65 years of age) who have provided informed consent.\n\nExclusion Criteria:\n\n* Inability to perform required study tests or procedures.\n* Positive safety tests indicating contraindications to manual intervention.\n* History of surgeries or trauma to the maxillofacial region.\n* Genetic defects or neurological disorders.\n* Current orthodontic treatment with fixed appliances.\n* Current splint therapy.\n* Pregnancy.\n* Lack of consent from a parent or legal guardian (for minors).\n* Lack of cooperation from the participant (especially children).","11 Years",{"count":131,"type":21},[24],"Goal: This clinical study aims to investigate how the range of motion of the temporomandibular joints (TMJ) changes in relation to the patient's head posture. Furthermore, we will assess the efficacy of a specific physiotherapy program in improving TMJ mobility and influencing head alignment in patients undergoing orthodontic treatment or prosthetic reconstruction.\n\nScope: The project will evaluate TMJ function and head alignment in orthodontic or prosthetic patients aged 11-65. The core focus is to analyze the correlation between head posture and TMJ mobility and to measure changes in these parameters before and after the manual physiotherapy intervention.",[28],[251,252,253,254,255,256],"temporomandibular joint","range of motion","cervical spine","kinematic","manual therapy","exercices","2025-12-19",{"date":259,"type":33},"2025-12-22",{"date":261,"type":21},"2026-01-20",{"date":263,"type":21},"2027-12-30",{"name":265,"class":40},"The Jerzy Kukuczka Academy of Physical Education in Katowice",{"id":267,"slug":4,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":271,"targetDuration":4,"studyType":22,"phases":273,"briefSummary":274,"conditions":275,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":41},"100463645","NCT05317390","Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia","Inclusion criteria:\n\n1. Males and females of diverse racial and ethnic backgrounds, with age across the lifespan;\n2. Patients will have at least one of the forms of dystonia, including focal dystonia (e.g., laryngeal, cervical, oromandibular, blepharospasm, focal hand, musicians), segmental dystonia, or generalized dystonia;\n3. Patients will have other movement disorders (Parkinson's disease, essential tremor, dyskinesia, myoclonus) and other non-neurological conditions (tic disorders, torticollis, ulnar nerve entrapments, temporomandibular disorders, dysphonia) that mimic dystonic symptoms.\n\nExclusion criteria:\n\n1. Patients who are incapable of giving informed consent;\n2. Patients who are unable to undergo brain MRI due to the presence of certain tattoos and ferromagnetic objects in their bodies (e.g., implanted stimulators, surgical clips, prosthesis, artificial heart valve) that cannot be removed or due to pregnancy or breastfeeding at the time of the study.",{"count":272,"type":21},1000,[24],"This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.",[276,277,278,279,280,281,282,283,284,28,285],"Dystonia","Drug Induced Dystonia","Parkinson Disease","Essential Tremor","Dyskinesias","Myoclonus","Tic Disorders","Torticollis","Ulnar Nerve Entrapment","Dysphonia","2025-11-24",{"date":288,"type":33},"2025-12-02",{"date":290,"type":33},"2022-06-01",{"date":292,"type":21},"2028-04-30",{"name":294,"class":40},"Massachusetts Eye and Ear Infirmary",{"id":296,"slug":4,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":179,"enrollmentInfo":300,"targetDuration":4,"studyType":22,"phases":302,"briefSummary":303,"conditions":304,"keywords":305,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":41},"100604303","NCT07147764","Comparison of the Effect of Pain Neuroscience Education Combined With Physiotherapy, and Physiotherapy Alone in Temporomandibular Disorders","Inclusion Criteria:\n\n* Diagnosed with pain-related TMDs according to DC\u002FTMD guidelines\n* Chronic TMD pain, defined as experiencing pain for at least six months and feeling the pain during the last 30 days\n* Age between 18-65 years\n\nExclusion Criteria:\n\n* Illiterate patients\n* Severe depression (medical diagnoses)\n* Previous diagnosis of uncontrolled psychiatric disorder neurodegenerative diseases\n* Clinical history of tumors in the craniofacial region\n* Patients in the post dental surgery period\n* Patients who were submitted to previous physical therapy in the past year or to any health\u002Fpain education strategy\n* Pregnant women\n* Infections, whiplash-associated disorders and with chronic degenerative inflammatory or neurologic disorders",{"count":301,"type":21},36,[24],"This research study aims to evaluate the effectiveness of Pain Neuroscience Education (PNE) when it is added to a physiotherapy program for people experiencing chronic temporomandibular disorders (TMD). To see whether adding PNE to physiotherapy program would provides additional benefits in reducing pain intensity, improving psychological well-being, and enhancing functional outcomes. The findings are expected to provide new insights into more comprehensive and patient-centered treatment strategies for managing chronic TMD.\n\nParticipants will be randomly assigned to one of two groups:\n\nControl Group: Physiotherapy only\n\nPNE Group: Physiotherapy plus Pain Neuroscience Education\n\nBoth groups will receive their respective treatments for a set period of time.",[28],[306,307,308],"Temporomandibular Disorder","Pain Neuroscience Education","Chronic Pain","2025-09-30",{"date":311,"type":33},"2025-10-03",{"date":313,"type":33},"2025-09-14",{"date":315,"type":21},"2026-06",{"name":317,"class":40},"Ainaz Shahedi",{"id":319,"slug":4,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":325,"conditions":326,"keywords":348,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":41},"100497203","NCT05754190","Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA","INCLUSION CRITERIA \\[General study\\]\n\n* Chronic pain group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of greater than 3 in the past week or\n  * Average pain interference score of greater than 3 in the past week or\n  * Average pain distress score of greater than 3 in the past week\n  * Pain duration: greater than 6 months\n* Acute pain group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of greater than 3 in the past week\n\n    ○ or\n  * Average pain interference score of greater than 3 in the past week\n\n    ○ or\n  * Average pain distress score of greater than 3 in the past week\n  * Pain duration: less than 3 months\n  * Pain cause: Due to recent surgery, injury, acute illness, or childbirth (within the past 3 months)\n* Healthy control group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of less than 3 in the past week\n  * Average pain interference score of less than 3 in the past week\n  * Average pain distress score of less than 3 in the past week\n  * No surgery, injury, acute illness, or childbirth (within the past 3 months)\n* In person EEG testing \\[Sub-Study only\\]:\n\n  * Same as in General App Study Above and additionally:\n  * Current diagnosis of Fibromyalgia, Chronic Low Back Pain or Failed Back Surgery Syndrome OR\n  * No current or prior history of chronic pain\n  * If participant has chronic low back pain or failed back surgery syndrome: are they planning to have either a radio-frequency ablation, back surgery, or spinal cord stimulation implant in the next few months\n  * If participant has chronic low back pain or failed back surgery syndrome: have they received insurance approval for the procedure?\n  * Ok with EEC\u002FECG measures\n\nEXCLUSION CRITERIA \\[General study\\]\n\n* Chronic pain group:\n\n  * recent injury or surgery unrelated to the pain in the past 3 months\n  * difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n  * Not fluent in English (difficulty understanding questions)\n  * Current primary or metastatic cancer (organic cause of pain)\n* Acute pain group:\n\n  * History of Chronic Pain (Pain lasting for more than 6 months)\n  * difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n  * Not fluent in English (difficulty understanding questions)\n  * Current primary or metastatic cancer (organic cause of pain)\n* Healthy control group:\n\nHistory of Chronic Pain (Pain lasting for more than 6 months)\n\n* difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n* Not fluent in English (difficulty understanding questions)\n\n  -In person EEG testing \\[Sub-study only\\]: \\[will interfere with EEG data collection safety or quality\\]:\n* Same as in General App Study Above and additionally:\n* Baldness\n* Pregnancy\n* Dreadlocks\n* Left-handedness\n* Use of a wheelchair\n* Heart failure diagnosis\n* Current or prior experience with acute psychosis or mania\n* implanted pacemaker, neurostimulator or any other head or heart implants\n* require a hearing aid to hear properly\n* claustrophobia\n* metal fragments in the body",{"count":324,"type":21},800,"This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms to identify computational predictors of acute-chronic pain transition, pain recovery, and\u002For chronic pain maintenance or flareups. The general study will include anyone with current acute or chronic pain, while a smaller sub-study will use a subset of patients from the chronic pain group who have been diagnosed with chronic low back pain, failed back surgery syndrome, or fibromyalgia. These sub-study participants will first take part in one in-person EEG testing session while completing simple interoception and reinforcement learning tasks and then begin daily use of the SOMA app. Electrophysiologic and behavioral data from the EEG testing session will be used to determine predictors of treatment response in the sub-study.",[308,327,328,329,330,331,332,333,334,335,28,336,337,338,339,340,341,342,343,344,345,346,347],"Acute Pain","Post Operative Pain","Fibromyalgia, Primary","Fibromyalgia, Secondary","Fibromyalgia","Irritable Bowel Syndrome","Chronic Headache Disorder","Chronic Migraine","Chronic Pelvic Pain Syndrome","Endometriosis-related Pain","Arthritis","Chronic Low-back Pain","Failed Back Surgery Syndrome","Post Herpetic Neuralgia","Neuropathic Pain","Painful Diabetic Neuropathy","Painful Bladder Syndrome","Trauma-related Wound","Trauma, Multiple","Chronic Pain Syndrome","Chronic Shoulder Pain",[349,350,351,352,353,354,355,356,357],"digital health","e-health","smartphone application","chronic pain","acute pain","symptom tracking","experience sampling methodology","ecological momentary assessment","pain self-management","2025-09-16",{"date":360,"type":33},"2025-09-19",{"date":362,"type":33},"2023-06-20",{"date":364,"type":21},"2026-05-30",{"name":366,"class":40},"Brown University",{"id":368,"slug":4,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":370,"acronym":4,"eligibilityCriteria":371,"healthyVolunteers":16,"sex":372,"minAge":18,"maxAge":179,"enrollmentInfo":373,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":375,"conditions":376,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":41},"100444551","NCT05068908","Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders","Inclusion Criteria: Main project\n\n* Provide signed and dated informed consent form.\n* Willing to comply with all study procedures and be available for the duration of study participation.\n* All participants will be females (biological sex by self-report) between ages 18 to 65 years (inclusive), as this includes the majority of the patient population at risk for chronic TMD pain.\n* Cases and controls will be matched for age within ±3 years, and all participants must be able to understand commands in English to follow study procedures (e.g., during sensory testing).\n\nPain-free controls\n\n* TMD-Pain screener score less than 3 out of 7 (Screener available as part of the DC\u002FTMD)\n* No previous diagnosis for the most common pain-related TMD as defined in the DC\u002FTMD criteria (myalgia, arthralgia, headache attributed to TMD)\n* No significant orofacial pain (jaw pain, TMJ pain) in past 3 months (\"significant\" meaning 5 or more days in any month or any pain during the past month)\n* No report of significant pain in the last 3 months elsewhere in the body (\"significant\" meaning 5 or more days in any month or any pain during the past month), e.g., low back pain, fibromyalgia, migraine headaches\n* Not meeting any of the most common pain-related TMD diagnosis as described in the DC\u002FTMD criteria (myalgia, arthralgia, headache attributed to TMD) upon clinical examination following the DC\u002FTMD protocol\n\nChronic painful TMD cases\n\n* TMD-pain screener score equal to or greater than 3\n* Primary TMD caseness criteria: myalgia (masticatory muscle pain) based on clinical exam following the DC\u002FTMD protocol\n\n  * Concurrent arthralgia (TMJ pain) and\u002For headache attributed to TMD allowed\n* Myofascial pain must meet the following criteria:\n\n  * Onset \\>3 months, occurring \\>15 days\u002Fmonth on average for \\>3 months\n  * Minimum 10 jaw pain episodes since onset, each episode lasting at least 30 minutes and no less than 2 hours within the day, OR unremitting\n* Low-impact TMD pain cases: Graded Chronic Pain Scale (GCPS) grade IIa or lower\n* High-impact TMD pain cases: GCPS grade IIb or greater\n\nInclusion criteria: Patients in MRI Optimization group\n\n* Be age 18-65 (inclusive)\n* Provide a signed and dated informed consent form.\n* Be willing to comply with all study procedures and be available for the duration of study participation.\n* Be able to understand commands in English to follow study procedures.\n\nExclusion Criteria: Main project\n\n* Traumatic facial injury or surgery on the face\u002Fjaw, arms or hands\n* Presence of pain related to dental or periodontal pathology\n* Currently undergoing active orthodontic treatment\n* Pregnant or nursing\n* Has any of the following medical conditions by self-report:\n\n  * Renal failure or dialysis\n  * Heart disease (examples: uncontrolled arrhythmia or hypertension, cardiomyopathy) or heart failure\n  * Non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema)\n  * Diabetes (Type I or II) that is not controlled with medication or diet\n  * Hyperthyroidism\n  * Uncontrolled seizures\n* Used any injection therapy (i.e. tender or trigger point injections, steroid injections), acupuncture, biofeedback, or TENS for the management of facial pain within 2 weeks prior to the screening assessment\n\n  * If undergoing botulinum toxin injections in the head and neck areas, must be 3 months since last set of injections and refrain from this treatment until study has ended\n* History of major depression or other major psychiatric disorder requiring hospitalization within the last 6 months prior to the screening assessments\n* History of treatment for drug or alcohol abuse within the last 12 months\n* Current pain medication use (e.g. opioids, ibuprofen, acetaminophen) that cannot be stopped \\\u003C24 hours prior to each study visit\n* Other conditions\u002Fdiseases associated with altered pain perception: neurological or developmental disorders (dementia, autism spectrum disorder), neoplasm, multiple sclerosis, trigeminal neuralgia\n* MRA contraindications including claustrophobia\n* GCPS grade assigned at Visit 1 that does not match grade from screening GCPS (low-, high-impact pain) and it is not possible to assign the potential participant to the correct final group, due to the latter having met their recruitment quota\n* Strictly left-handedness by self-report\n* Thermal threshold for Pain-50 (determined at Visit 1) is outside the temperature range of 40-49 degrees Celsius\n* Lack of access to electronic device with internet connection during the study\n* Inability or unwillingness to receive daily text messages during the study\n* Inability to complete at least four daily ratings between the Informed consent, Pre- visit 1 procedures and in-person visit 1\n* Anything that would place the individual at increased risk or preclude the individual's full compliance with study procedures or completion of the study.\n\nExclusion criteria: MRI Optimization group\n\nPregnant or nursing;\n\n* MRI contraindications including claustrophobia;\n* Adults lacking capacity to provide informed consent for themselves;\n* Unable to understand instructions for sensory testing in English;\n* Anything that would place the individual at increased risk or preclude the individual's full compliance with study procedures or completion of the study.","FEMALE",{"count":374,"type":21},95,"This study addresses the timely problem of painful temporomandibular disorders (TMD), the most common cause of orofacial pain second only to tooth pain. Findings from previous studies suggest that dysregulation of connectivity within specific brain circuits is part of chronic pain pathophysiology. This study will identify connectivity patterns within those brain circuits as potential signatures for pain- related disability in chronic TMD pain participants. New knowledge regarding these brain connectivity patterns is expected to be significant because it will support improved phenotyping of this heterogeneous participant population. It is also expected that this finding can potentially be extrapolated to other chronic pain conditions, such as back pain, migraine headache, and fibromyalgia that are frequently comorbid conditions in chronic TMD participants.",[308,28,78],"2025-09-04",{"date":379,"type":33},"2025-09-08",{"date":381,"type":33},"2022-03-02",{"date":383,"type":21},"2026-08-31",{"name":385,"class":40},"University of Minnesota",{"id":387,"slug":4,"hasResults":11,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":391,"eligibilityCriteria":392,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":393,"enrollmentInfo":394,"targetDuration":4,"studyType":22,"phases":396,"briefSummary":397,"conditions":398,"keywords":401,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":4},"100602958","NCT07130279","Post-Isometric Relaxation in Temporomandibular Disorders","The Effect of Post-Isometric Relaxation Technique on Cervical Range of Motion, Mandibular Mobility, Head Anterior Tilt, and Kyphotic Posture in Individuals With Temporomandibular Joint Dysfunction","PIR-TMD","Inclusion Criteria:\n\n* Age between 18 and 25 years\n* Diagnosis of moderate or severe temporomandibular joint dysfunction (TMD) according to the Fonseca Anamnestic Questionnaire\n* Presence of TMD symptoms for at least 6 months\n* No TMD treatment received within the last 6 months\n* Presence of chewing muscle pain for at least 6 months\n* Able and willing to participate in the study and follow the exercise program\n* Signed informed consent form\n\nExclusion Criteria:\n\n* History of jaw or facial trauma within the past year\n* History of temporomandibular joint surgery\n* Presence of systemic rheumatologic, neurological, or musculoskeletal disorders affecting the jaw, neck, or spine\n* Pregnancy\n* Current participation in another clinical trial\n* Inability to perform the exercise program due to medical or physical limitations\n* Refusal to provide informed consent","25 Years",{"count":395,"type":21},40,[24],"This planned randomized, single-blind clinical trial will investigate the effects of adding the Post-Isometric Relaxation (PIR) technique to a standard postural exercise program in individuals with moderate to severe temporomandibular joint dysfunction (TMD). Forty volunteers aged 18-25 years will be recruited and randomly assigned to either an experimental group (postural exercises + PIR) or a control group (postural exercises only). The intervention will be delivered three times per week for six weeks. Primary outcomes will include cervical range of motion, mandibular mobility, head anterior tilt, and thoracic kyphosis index, measured before and after the intervention. The study aims to determine whether PIR provides additional benefits to standard postural exercises in improving jaw and neck function and postural alignment in young adults with TMD.",[28,399,400],"Myofascial Pain Syndromes","Mandibular Dysfunction",[402,403,252],"Temporomandibular Joint Dysfunction","Post-Isometric Relaxation","2025-08-12",{"date":406,"type":33},"2025-08-19",{"date":408,"type":21},"2025-08-11",{"date":410,"type":21},"2025-09-25",{"name":412,"class":40},"Sanem ŞENER",{"id":414,"slug":4,"hasResults":11,"nctId":415,"briefTitle":416,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":16,"sex":17,"minAge":418,"maxAge":419,"enrollmentInfo":420,"targetDuration":4,"studyType":22,"phases":421,"briefSummary":422,"conditions":423,"keywords":426,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":4},"100592884","NCT06999239","Evaluation of the Effect of Laser Therapy on Lateral Pterygoid Muscle in Patients With Wilke's Stage I and II Temporomandibular Disorders (TMD): Case Series Study","Inclusion criteria:\n\n1. Patients age between 16-50 years with no sex predilection.\n2. Patients who will be free from any systemic diseases that affect temporomandibular joint.\n3. Patients who will be diagnosed with wilk's stage I and II temporomandibular disorders (TMD).\n4. Patients who will be ready to give informed consent.\n\nExclusion Criteria:\n\n1. Patients with previous temporo-mandibular surgeries.\n2. Patients with previous facial fracture.\n3. Patients who will be under another type of treatment for TMD (e.g., occlusal splints, pharmacological drugs, or head and neck surgery).\n4. Patients who will not attend the proposed treatment sessions or follow-up visits.","16 Years","50 Years",{"count":7,"type":21},[24],"The purpose of this study will be to evaluate the effect of laser therapy on lateral pterygoid muscle in patients with Wilke's stage I and II temporomandibular disorders (TMD).",[424,28,425],"Laser","Lateral Pterygoid Muscle",[427],"laser therapy, lateral pterygoid muscle, Wilke's, stage I and II, TMD.","2025-06-10",{"date":430,"type":33},"2025-06-13",{"date":432,"type":21},"2025-07",{"date":434,"type":21},"2026-08",{"name":190,"class":40},{"id":437,"slug":4,"hasResults":11,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":442,"enrollmentInfo":443,"targetDuration":4,"studyType":22,"phases":445,"briefSummary":446,"conditions":447,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":4},"100591803","NCT06985173","Patient Satisfaction in Occlusal Splints Fabricated Using Fully Digital Versus Conventional Workflow","Patient Satisfaction and Occlusal Adjustments in Occlusal Splints Fabricated Using Fully Digital Versus Conventional Workflow in TMD Patients. (Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* 18-40 years old\n* Complete dentition.\n* Normal jaw opening.\n* Intact teeth.\n* No ongoing dental therapy, such as orthodontic or prosthodontic treatment.\n* TMD patients with more than one of following symptoms or signs: myofascial pain and \u002For pain in the TMJ, myofascial pain and\u002For pain in the TMJ on palpation, muscles tenderness, headache or earache.\n* Patients who had unsuccessfully undergone splint therapy or other TMD treatments in the past were not excluded.\n\nExclusion Criteria:\n\n* Patients with systemic diseases which could affect TMJ, e.g., rheumatoid arthritis, osteoarthrosis, osteoporosis, and patients taking analgesic, muscle relaxant, or anti inflammatory drugs were excluded because such drugs could influence the results.\n* Temporomandibular joint lesions found on clinical palpation or medical imaging examination.\n* Jaw opening less than 3 fingers.\n* Patients with occlusal dysfunctions.\n* Patients with severe or moderate periodontitis.\n* Unable to undergo examination or treatment due to the presence of a psychological or mental disorder.","40 Years",{"count":444,"type":21},32,[24],"According to published literatures, the prevalence of TMD is approximately 10% in patients over 18 years of age with a considerable proportion being women of reproductive age. The treatment of TMD presents the following goals: decreasing joint and masticatory muscle pain, increasing the range of motion in the mandible, preventing degenerative changes in the articulating tissues. Management of TMD can be either conservative or surgical treatments, the conservative treatments include analgesia, medications, physical therapy, occlusal adjustment, splint therapy, localized steam application, and external muscle massage. The occlusal splint therapy is considered a common treatment option for TMD management. Flat stabilization splint is the preferred splint for such cases. It is designed to promote occlusal stability and decrease muscles tension by altering occlusion and allowing complete seating of the condyle in centric relation.\n\nThe evolution of digital technology created new era of dentistry that successfully digitalized the traditional workflow of occlusal splints including designing and manufacturing. Furthermore, virtual facebow and dynamic jaw relation record using jaw tracking device are another digital reward. The digital workflow can offer more predictable approach for occlusal splint construction, It could eliminate the traditional technical errors and enhance the occlusal accuracy",[28],"2025-05-21",{"date":450,"type":33},"2025-05-22",{"date":452,"type":21},"2025-07-01",{"date":454,"type":21},"2026-01-01",{"name":190,"class":40},{"id":457,"slug":4,"hasResults":11,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":462,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":463,"conditions":464,"keywords":465,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":470,"completionDateStruct":472,"leadSponsor":474,"locationsCount":41},"100589189","NCT06951178","Long-term Safety and Performance of Materialise's Patient-specific TMJ System.","Unlocking TMJs Clinical Study: Safety and Performance of Materialise's Patient-specific TMJ System","Inclusion Criteria:\n\n* Patients prescribed with Materialise TMJ Total Arthroplasty System for TMJ reconstruction\n* Patient who has received and understood the study information leaflet and has agreed to participate in the study and signed the informed consent form (ICF) (adult or legal guardian(s) if minor).\n\nExclusion Criteria:\n\n* Known hypersensitivity to Titanium, Nickel, or Cobalt-Chrome alloys.\n* Patient conditions where there is not enough bone quality or quantity to support the components.\n* Active infection in the anatomical area or the vicinity of the site to be implanted, preventing the implantation of the device.\n* Patients with marked hyperfunctional habits (e.g., tooth clenching, bruxism).\n* Pregnant woman.\n* Patient is known to be or suspected of being unable to comply with the study protocol or proposed follow-up visits by the investigator.",{"count":73,"type":21},"This is a long-term (10 years), retrospective-prospective, observational, single-arm, monocenter study of patients to be treated with the Materialise TMJ Total Arthroplasty System for TMJ replacement. The study will evaluate the efficiency, safety, clinical performance, accuracy, benefits, and risks associated with long-term use and the impact on life quality and diet of the TMJ system, its fixation devices, TMJ Implant trial, and guides in the adolescent and adult populations.",[28],[28,466],"Implant","2025-04-22",{"date":469,"type":33},"2025-04-30",{"date":471,"type":21},"2025-06",{"date":473,"type":21},"2037-06",{"name":475,"class":99},"Materialise",{"id":477,"slug":4,"hasResults":11,"nctId":478,"briefTitle":479,"officialTitle":480,"acronym":4,"eligibilityCriteria":481,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":482,"enrollmentInfo":483,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":485,"conditions":486,"keywords":487,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":492,"startDateStruct":494,"completionDateStruct":496,"leadSponsor":498,"locationsCount":500},"100530442","NCT06186830","Cognitive Exercise Therapy Approach Biopsychosocial Questionnaire (BETY-BQ) in Patient with Temporomandibular Disorders","Validity, Reliability and Responsiveness of the Cognitive Exercise Therapy Approach Biopsychosocial Questionnaire in Individuals with Temporomandibular Disorder","Inclusion Criteria:\n\n* Having received a diagnosis of temporomandibular disorder\n\nExclusion Criteria:\n\n* Experiencing difficulty in cooperating to fill out the questionnaires\n* Being unwilling to participate in the study","64 Years",{"count":484,"type":21},150,"The aim of this study is to investigate the validity, reliability, and responsiveness of the Cognitive Exercise Therapy Approach-Biopsychosocial Questionnaire (BETY-BQ) in individuals with temporomandibular disorder. The following are alternative hypotheses of the study:\n\n* BETY-BQ has significant convergence with the Patient Health Questionnaire-9 measuring depression.\n* BETY-BQ has significant convergence with the Patient Health Questionnaire-15 measuring physical symptoms.\n* BETY-BQ has significant convergence with the Generalized Anxiety Disorder-7 measuring anxiety.\n* BETY-BQ has significant convergence with the Short Form-36 measuring quality of life.\n* BETY-BQ has significant convergence with the Craniomandibular Pain and Disability Inventory measuring disability.\n* BETY-BQ has significant convergence with the Mandibular Function Impairment Questionnaire measuring function.\n* BETY-BQ has significant stability.\n* BETY-BQ has significant internal consistency.",[306,28,137],[488,489,490],"validity","reliability","responsiveness","2025-03-11",{"date":493,"type":33},"2025-03-13",{"date":495,"type":33},"2023-12-17",{"date":497,"type":21},"2025-08",{"name":499,"class":40},"Hacettepe University",2,{"id":502,"slug":4,"hasResults":11,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":4,"eligibilityCriteria":506,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":71,"enrollmentInfo":507,"targetDuration":4,"studyType":22,"phases":508,"briefSummary":509,"conditions":510,"keywords":511,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":41},"100439797","NCT05006963","Tele-Rehabilitation in Patients With Temporomandibular Dysfunction","Tele-Rehabilitation in Patients With Temporomandibular Dysfunction: Randomized, Controlled and Blind","1. Age between 18 and 60 years;\n2. presence of pain in the facial region in the last 6 months;\n3. diagnosis of myalgia, arthralgia, headache attributed to temporomandibular disfunction and\u002For subluxation temporomandibular joint.",{"count":156,"type":21},[24],"Temporomandibular disorder or TMD is characterized by a set of symptoms such as: pain, decreased range of motion and joint noise. It's origin is multifactorial, which may be related to biological aspects, environmental and psychosocial. The multimodal approach has been widely used in physiotherapy for the treatment of TMDs. Physiotherapy has been walking together with technology so that telerehabilitation can be a reality, contributing so that quality care reaches the patient, in the impossibility office-to-face service. The objective of this study is to verify the effect of telerehabilitation on pain outcomes, range of motion, functionality and biopsychosocial aspects in individuals with temporomandibular disorders. Will be a randomized, controlled and blinded clinical trial was carried out. The study will be divided into two moments: evaluation and intervention. Evaluations will be carried out using the Diagnostic Criteria for Temporomandibular Disorders: Clinical Protocol and Assessment Instruments (DC\u002FTMD), the Fonseca Anamnesis Index (IAF), the Numerical Pain Scale (END) and the Functional Limitation Questionnaire (MFIQ). Individuals will be randomized into 2 groups: Group A (in person) Group B (telerehabilitation). Both groups will receive treatment physical therapy for 12 weeks. After collecting the data, they will be tabulated and analyzed using a 5% significance level.",[306,28,137],[512,513,514,515,516,517,518,519,520],"temporomandibular joint disorders","clinical protocols","physiotherapy","remote consultation","telemedicine","telehealth","telerehabilitation","teletherapy","telepractice","2025-02-27",{"date":523,"type":33},"2025-03-04",{"date":525,"type":33},"2021-09-30",{"date":527,"type":21},"2027-03-30",{"name":529,"class":40},"University of Nove de Julho",{"id":531,"slug":4,"hasResults":11,"nctId":532,"briefTitle":533,"officialTitle":534,"acronym":4,"eligibilityCriteria":535,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":22,"phases":537,"briefSummary":538,"conditions":539,"keywords":540,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":545,"completionDateStruct":547,"leadSponsor":549,"locationsCount":41},"100578572","NCT06813040","Efficacy of Repetitive Transcranial Magnetic Stimulation in Temporomandibular Disorders.","Efficacy of Repetitive Transcranial Magnetic Stimulation in Chronic Pain in Patients with Temporomandibular Disorders.","Inclusion Criteria:\n\n* Individuals of both sexes, literate, aged over 18 years with the diagnosis of muscular and\u002For joint TMD by the Diagnostic Criteria for Temporomandibular Disorders (DC-TMD).\n* Pain duration longer than 6 months.\n* Intensity of orofacial pain greater than 5 on the visual analogue scale (VAS).\n\nExclusion Criteria:\n\n* Volunteers who present verbal communication impairment due to a neurological disorder, a sequel to a previous illness, or a psychiatric condition.\n* Pregnant women\n* Individuals with any impediment to MRI: having a pacemaker or implantable defibrillator, cochlear implant, ferromagnetic aneurysm clips, electrodes used for deep brain stimulation, ocular implants, Swan-Ganz catheter, orthopedic prostheses or metallic bodies close to the area of interest.\n* Individuals with any contraindication for transcranial magnetic stimulation: have focal or generalized encephalopathies, increased intracranial pressure, and severe heart disease; history of head trauma, epilepsy, and individuals with first-degree relatives diagnosed with idiopathic epilepsy; use of drugs that lower the seizure threshold (tricyclic antidepressants and antipsychotics); chronic use of alcohol or epileptogenic drugs.",{"count":395,"type":21},[24],"Temporomandibular disorder (TMD) refers to a group of musculoskeletal conditions that affect the temporomandibular joint (TMJ), the masticatory muscles, and the associated structures. It is assumed that 30 to 40% of cases of acute painful TMD becomes chronic. Chronic pain is a significant public health problem, affecting professional and social activities, emotional state, and quality of life. The pathophysiological mechanisms involved in chronic orofacial pain are complex and multifaceted and not yet fully understood. The coexistence of psychological factors associated with vast peripheral and central mechanisms makes chronic orofacial pain treatment a complex challenge. Due to the complexity of chronic TMDs, some patients remain refractory to current therapeutic methods. Thus, several efforts have been made to develop therapies aimed at the treatment of neuroplastic changes induced by chronic pain. In this sense, transcranial stimulation methods appear to be a promising technique. Transcranial Magnetic Stimulation (TMS) is a non-invasive, safe, and approved treatment for clinical use in psychiatric disorders such as depression and chronic pain. Given the above, it is necessary to develop studies to investigate the TMS effectiveness in chronic TMD. This study aims to evaluate the effectiveness of transcranial magnetic stimulation in patients with chronic temporomandibular disorders. An additional objective is to determine possible predictors for treatment success based on the assessment of functional brain connectivity and psychosocial characteristics.",[28],[28,541],"TMJ disorders","2025-02-10",{"date":544,"type":33},"2025-02-13",{"date":546,"type":33},"2024-01-01",{"date":548,"type":21},"2027-05-30",{"name":550,"class":40},"University of Coimbra",{"id":552,"slug":4,"hasResults":11,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":11,"sex":17,"minAge":557,"maxAge":442,"enrollmentInfo":558,"targetDuration":4,"studyType":22,"phases":559,"briefSummary":560,"conditions":561,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":41},"100574756","NCT06763419","Internal Photobiomodulation For Management Of Temporomandibular Joint Internal Derangement","Internal Photobiomodulation For Management Of Temporomandibular Joint Internal Derangement: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Painful click at temporomandibular joint (TMJ) area.\n* Pain at the lateral pterygoid muscle.\n* Presence of full or nearly full complement of natural teeth with acceptable occlusion\n\nExclusion Criteria:\n\n* Patients who have radiographic evidence of degenerative conditions of TMJ.\n* Patients under current dental or physical therapy that could affect TMD.\n* History of recent trauma.\n* The presence of systemic diseases (i.e. rheumatoid arthritis, osteoarthritis).\n* Pregnant and lactating females.\n* Presence of open bite.","20 Years",{"count":156,"type":21},[24],"Aim of the study was to compare the efficacy of internal versus external photobiomodulation (PBM) in the management of patients with TMJ internal derangements (TMJ-ID).",[28],"2025-01-06",{"date":564,"type":33},"2025-01-08",{"date":566,"type":33},"2024-12-25",{"date":568,"type":21},"2025-02-28",{"name":570,"class":40},"Nourhan M.Aly",{"id":572,"slug":4,"hasResults":11,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":4,"eligibilityCriteria":576,"healthyVolunteers":16,"sex":17,"minAge":577,"maxAge":578,"enrollmentInfo":579,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":580,"conditions":581,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":41},"100571503","NCT06721104","Balance, TMJ, Social Adaptive Assessment in Individuals With Autism Spectrum Disorder","'Evaluation of Temporomandibular Joint Dysfunction, Balance, Cervical Posture, Dual Task, and Social Adjustment in Individuals With Autism Spectrum Disorder'","Inclusion Criteria:\n\n* Having a diagnosis of Autism Spectrum Disorder (ASD) confirmed by a physician.\n* Currently enrolled in a special education and rehabilitation center.\n* No vision problems.\n* Ability to understand and follow instructions.\n* No cognitive impairments.\n* No walking difficulties.\n\nExclusion Criteria:\n\n* Individuals with comorbid secondary health conditions.\n* Individuals who have undergone surgery in the past six months.","4 Years","21 Years",{"count":218,"type":21},"The aim of our study is to evaluate temporomandibular joint (TMJ), cervical posture, balance, dual-task performance, and social adaptation skills in individuals with autism. The study will be conducted at Bartın Lider Special Education and Rehabilitation Center following the approval of the ethics committee. Individuals determined by the sample size calculated through power analysis will be included in the study. First, the socio-demographic characteristics (age, height, body weight, body mass index, education level, exercise and smoking habits, etc.) of the participants who voluntarily join the study will be recorded. Participants will be divided into two groups: individuals with typical motor development and those with autism spectrum disorder (ASD), and the same assessment tools will be used for both groups. Individuals with typical motor development will serve as the control group.\n\nThe assessment tools include the Timed Up and Go (TUG) test, the 10-Meter Walk Test, the Vineland Adaptive Behavior Scale, the PostureScreen Android-based posture assessment application, and the Helkimo Clinical Dysfunction Index for craniomandibular disorders. Based on the evaluation results, the relationships between TMJ, cervical posture, functional balance, dual-task performance, and social adaptation skills in individuals with autism will be analyzed and compared with those of individuals with typical motor development.",[582,28,583],"Autism Spectrum Disorder","Postural; Defect","2024-12-05",{"date":586,"type":33},"2024-12-06",{"date":588,"type":33},"2024-02-15",{"date":590,"type":21},"2025-05-25",{"name":592,"class":40},"Kırıkkale University",{"id":594,"slug":4,"hasResults":11,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":4,"eligibilityCriteria":598,"healthyVolunteers":11,"sex":372,"minAge":18,"maxAge":599,"enrollmentInfo":600,"targetDuration":4,"studyType":22,"phases":601,"briefSummary":602,"conditions":603,"keywords":605,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":610,"lastUpdatePostDateStruct":611,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":617,"locationsCount":41},"100554538","NCT06500390","Temporomandibular Disorder in Use of Levonorgestrel Intrauterine System","Is the Incidence of Temporomandibular Disorder Increased in the Use of Levonorgestrel Intrauterine System","Inclusion Criteria:\n\n* Being a woman\n* Having used an intrauterine device for at least 3 months\n* Being between the ages of 18-50\n* Being in American Society of Anesthesiologists-1 and American Society of Anesthesiologists-2 systemic status\n\nExclusion Criteria:\n\n* Patients with craniofacial syndrome\n* Patients with a history of head and neck trauma\n* Isolated muscle tenderness or previous surgery on TMJ\n* Patients with rheumatological disorders\n* Patients with an additional gynecological disease other than endometriosis\n* Lack of cooperation with the patient.","45 Years",{"count":131,"type":21},[24],"The goal of this clinical trial is to investigate the possible role of levonorgestrel intrauterine system use(LIU) in the pathogenesis of temporomandibular joint disorder (TMD). In this clinical trial, levonorgestrel intrauterine system patients (n=30) aged 25-50 and control group patients (n=30) with the same demographics and age range are used. The main questions it aims to answer are:\n\nTo compare the frequency of temporomandibular dysfunction in women using the levonorgestrel intrauterine system with the control group of the same demographic and age range.\n\nThe levonorgestrel intrauterine system use group consisted of 50 women who had previously a mirena implanted by a gynecologist at least 3 months ago due to menstrual bleeding and pelvic pain.\n\nThe control group included 50 randomised healthy women who had regular menstrual cycles and were not taking any medication.",[604,28,306],"Levonorgestrel Adverse Reaction",[606,607,608,609],"Mirena","Levonorgestrel","Intrauterine system","Temporomandibular disorder","2024-11-21",{"date":612,"type":33},"2024-11-25",{"date":614,"type":33},"2024-01-15",{"date":616,"type":21},"2024-12-15",{"name":618,"class":40},"Marmara University",{"id":620,"slug":4,"hasResults":11,"nctId":621,"briefTitle":622,"officialTitle":623,"acronym":4,"eligibilityCriteria":624,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":625,"enrollmentInfo":626,"targetDuration":4,"studyType":22,"phases":627,"briefSummary":630,"conditions":631,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":633,"lastUpdatePostDateStruct":634,"startDateStruct":636,"completionDateStruct":638,"leadSponsor":640,"locationsCount":41},"100569460","NCT06694532","EffIcacy Between Arthrocentesis With High Versus Low Molecular Weight Hyaluronic Acid in Treatment of TMJ Disorders","Comparative Study Between the Effectiveness of High Versus Low Molecular Weight Hyaluronic Acid in TMJ Arthrocentesis","Inclusion Criteria:\n\n* Pain or tenderness of the jaw\n* Pain in one or both of the temporomandibular joints\n* Aching pain in and around your ear\n* Difficulty chewing or pain while chewing\n* Aching facial pain\n* Locking of the joint,\n\nExclusion Criteria:\n\n* Muscular TMJ disorders\n* Bleeding tendency","100 Years",{"count":73,"type":21},[628,629],"PHASE1","PHASE2","The study will be carried out in Patients in two Groups aged between 17 to 70 years , of both sexes, who had painful symptoms, with or without presence of joint noise, and had unilateral or bilateral internal derangement of the TMJ proven by clinical examination, with no improvement after conservative treatment.",[28,632],"Arthrocentesis","2024-11-15",{"date":635,"type":33},"2024-11-19",{"date":637,"type":33},"2023-10-31",{"date":639,"type":21},"2026-02-28",{"name":641,"class":40},"Basel khaled mohamed",""]