[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"the-focus-is-to-develop-a-closed-loop-control-system-for-anaesthesia-in-vitroretinal-surgery-surgery-due-to-expansive-processes-in-head-and-long-term-sedation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:the-focus-is-to-develop-a-closed-loop-control-system-for-anaesthesia-in-vitroretinal-surgery-surgery-due-to-expansive-processes-in-head-and-long-term-sedation":37},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":14,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":5},"100329485",false,"NCT03569839","Modeling and Closed-loop Control of Depth of Anaesthesia","Inclusion Criteria:\n\n* patients having vitroretinal surgery in general anaesthesia\n* patients having brain surgery in general anaesthesia\n* patients needing sedation in ICU\n* ASA 1-3\n\nExclusion Criteria:\n\n* ASA \\> 3\n* BMI \\> 35\n* drug addicts\n* patients taking psychotropic medicines\n* patients taking opioid analgesics (including tramadol)\n* severe psychiatric disease\n* central nervous system disease (except the reason for surgery)\n* arrhythmia affecting or preventing the measurements (e.g. chronic atrial fibrillation)\n* patients that received benzodiazepines",true,"ALL","20 Years","70 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","The study evaluates the effect of anaesthetic agents to depth of anaesthesia. An improved PK-PD model wil be developed that will provide the basis for understanding the mechanisms, simulating various scenarios and developing algorithms for better and safer administration of anaesthetic agents.",[24],"The Focus is to Develop a Closed-loop Control System for Anaesthesia in Vitroretinal Surgery, Surgery Due to Expansive Processes in Head, and Long-term Sedation","RECRUITING","2026-05-05",{"date":28,"type":29},"2026-05-11","ACTUAL",{"date":31,"type":29},"2017-09-14",{"date":33,"type":20},"2028-12",{"name":35,"class":36},"University of Ljubljana","OTHER",""]