[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thin-peri-implant-mucosal-phenotype\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thin-peri-implant-mucosal-phenotype":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100643946",false,"NCT07667855","Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft","Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Systemically healthy adults (Between 18 and 65) with one or more dental implants requiring second-stage surgery in the esthetic zone (Anteriors and Premolars).\n* Thin soft tissue phenotype: mucosal thickness or KTW \\\u003C2 mm buccally.\n* Stable osseointegrated implant, adequate restorative space, and healthy adjacent teeth.\n* Good oral hygiene (PI ≤10%), with peri-implant maintenance.\n* Signed consent + willingness for 1-year follow-up.\n\nExclusion Criteria:\n\n* Heavy smokers (≥10 cig\u002Fday); light smokers only if reduced.\n* Systemic\u002Fhealing issues: uncontrolled diabetes, immunocompromise, bleeding disorders, anticoagulants, steroids.\n* Pregnancy or breastfeeding.\n* Active infection (periodontal or peri-implant).\n* No residual keratinized mucosa on buccal side.\n* Previous graft\u002Faugmentation at the site or recent surgery (\\\u003C6 months).\n* Allergies to anesthetics\u002Fmaterials.\n* Non-compliance with instructions or follow-up.","ALL","18 Years","65 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","This randomized controlled clinical trial aims to evaluate a minimally invasive technique for peri-implant soft tissue augmentation using microneedling combined with injectable platelet-rich fibrin (i-PRF) compared with the current gold-standard connective tissue graft (CTG). Patients with thin peri-implant soft tissue requiring implant second-stage surgery in the esthetic zone will be randomly assigned to receive either CTG harvested from the palate or a series of microneedling and i-PRF treatments. Clinical outcomes including mucosal thickness, keratinized tissue width, peri-implant health parameters, volumetric soft tissue changes, esthetic outcomes, and patient-reported measures of pain and satisfaction will be evaluated during follow-up. The study aims to determine whether microneedling with i-PRF can provide comparable soft tissue augmentation while reducing patient morbidity associated with connective tissue graft harvesting.",[26],"Thin Peri-implant Mucosal Phenotype",[28,29,30,31,32,33,34],"Microneedling","Injectable Platelet-Rich Fibrin","i-PRF","Peri-implant soft tissue augmentation","Implant Esthetics","Mucosal Thickness","Connective Tissue Graft","NOT_YET_RECRUITING","2026-06-19",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":20},"2026-06-26",{"date":43,"type":20},"2027-03-26",{"name":45,"class":46},"Beirut Arab University","OTHER",""]