[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"treatment-of-spontaneous-intracerebral-hemorrhage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:treatment-of-spontaneous-intracerebral-hemorrhage":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100415226",false,"NCT04686877","Safety and Efficacy of Stereotactic Aspiration Plus Urokinase in Deep Intracerebral Hemorrhage Evacuation","Safety and Efficacy of Stereotactic Aspiration Plus Urokinase in Deep Intracerebral Hemorrhage Evacuation: a Multicentral Randomized, Controlled, Open-label, Trial","STAPLE-dICH","Inclusion criteria:\n\n1. aged 40 years or older;\n2. the duration from onset to the baseline computed tomography angiography (CTA) scan was between 6 to 24 hours;\n3. patients with a spontaneous ICH in the deep brain parenchyma (≥1 cm from the cortical surface); with hematoma volume more than 25 ml (measured with the ABC\u002F2 method); without hydrocephalus caused by intraventricular hemorrhage; without cerebral herniation and the benefit of surgical treatment was unknown;\n4. The Glasgow Coma Scale (GCS) ranged from 9 to 15;\n5. patients with motor deficits;\n6. The modified Rankin Score (mRS) ranged from 0 to1 before onset.\n\nExclusion Criteria:\n\n1. ICH was caused by aneurysms, arteriovenous malformations, tumors, or trauma;\n2. patients had a history of intracerebral hemorrhage or ischemic cerebral infarction;\n3. patients had severe coagulation disorders with INR ≥ 1.5;\n4. patients had severe underlying diseases, which may affect the outcomes;\n5. pregnant and lactating patients;\n6. patients refused to sign the informed consent and receive follow-up.","ALL","40 Years",{"count":19,"type":20},400,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a nationwide, multicenter, open-label, randomized controlled trial of early minimally invasive treatment for deep-seated spontaneous cerebral hemorrhage (dICH). The study consists of 2 steps: the first step is to conduct a dose climbing test to determine the safety and optimal dose of urokinase intra-hematoma irrigation after stereotactic aspiration; the second step is to validate whether stereotactic aspiration plus urokinase irrigation (the optimal dose determined in step one) is superior to conservative treatment in improving long-term outcomes (1 year) in early (within 24h) dICH patients.",[26],"Treatment of Spontaneous Intracerebral Hemorrhage",[28,29,30,31,32],"Deep-Seated Spontaneous Intracerebral Hemorrhage","Stereotactic Aspiration","Urokinase Irrigation","Randomized Controlled Trial","Long-term outcome","RECRUITING","2025-02-08",{"date":36,"type":37},"2025-02-12","ACTUAL",{"date":39,"type":37},"2021-01-31",{"date":41,"type":20},"2025-09-30",{"name":43,"class":44},"First Affiliated Hospital of Fujian Medical University","OTHER",""]