[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ush2a-variant-retinitis-pigmentosa\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ush2a-variant-retinitis-pigmentosa":36},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":14,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":25,"lastUpdatePostDateStruct":26,"startDateStruct":29,"completionDateStruct":31,"leadSponsor":33,"locationsCount":4},"100557987",false,"NCT06545253","A New Diagnostic Paradigm for Retinitis Pigmentosa Secondary to USH2A Pathogenic Variants","Inclusion Criteria:\n\n* age \\>18 years\n* genetically confirmed diagnosis of USH2A-RP\n* availability of genetic tests to assess the pathogenic variants\n\nExclusion Criteria:\n\n* inability to understand and sign the written informed consent form\n* any inflammatory, infectious or degenerative eye disease\n* media opacities resulting incompatible with good imaging quality\n* uncontrolled systemic, metabolic, autoimmune neuroinflammatory and neurodegenerative disease\n* ophthalmologic surgery within the previous six months",true,"ALL","18 Years",{"count":18,"type":19},60,"ESTIMATED","OBSERVATIONAL","Aim of the study is to perform a non-invasive multimodal retinal imaging investigation in a cohort of patients affected by USH2A retinitis pigmentosa (USH2A-RP), in order to develop a new diagnostic paradigm to categorize clinically relevant subgroups. All the procedures will be performed according to normal clinical practice. In addition, a novel quantitative profiling of serum microRNAs will be carried out in order to analyze the clinical importance of microRNA biomarkers in the clinical setting of the disease.",[23],"USH2A Variant Retinitis Pigmentosa","NOT_YET_RECRUITING","2024-08-06",{"date":27,"type":28},"2024-08-09","ACTUAL",{"date":30,"type":19},"2024-08",{"date":32,"type":19},"2027-02",{"name":34,"class":35},"IRCCS Ospedale San Raffaele","OTHER",""]