[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vasodilatory-hypotension-during-or-after-cardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vasodilatory-hypotension-during-or-after-cardiac-surgery":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100553553",false,"NCT06487585","ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)","Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery (ANG-First Trial)","Inclusion Criteria:\n\n* Adult patients ≥ 18 years of age undergoing cardiac surgery requiring CPB\n* Patients must have clinical features of vasodilation as determined by a MAP \\\u003C 65 mmHg that is non-transient in the opinion of the treating physician\n* Patients must be adequately volume resuscitated in the opinion of the treating physician\n* Systemic Vascular Resistance index (SVRi) \\\u003C 1970 dynes·sec\u002Fcm⁵\u002Fm² to support the clinical diagnosis of vasodilation; if no pulmonary artery catheter is in place, vasodilatory hypotension diagnosis according to the judgement of the critical care team\n* Biventricular systolic function is at or greater than pre-cardiopulmonary bypass baseline as demonstrated by echocardiographic evaluation, or the patient is concomitantly treated with\n\nExclusion Criteria:\n\n* Bleeding as primary etiology of hypotension, as determined by \\> 4 units RBC transfusion in 24 hours.\n* Patients on ECMO\n* Patients with active endocarditis\n* Patients already on renal replacement therapy or creatinine of \\> 4 mg\u002Fdl within 2 weeks of surgery\n* Patients with contraindications to Angiotensin II including women who are pregnant or breastfeeding or have active coronary ischemia, mesenteric ischemia, limb ischemia, or high potassium (\\> 5.5 meq\u002FL) while receiving Angiotensin II",true,"ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The purpose of this research is to evaluate the use of Angiotensin II in patients with low blood pressure post-surgery. Your information will be collected for 28 days post the procedure and initiation of the study drug to assess for safety events and complications.",[26],"Vasodilatory Hypotension During or After Cardiac Surgery",[28,29,30,31],"Vasodilation","Hypotension","Cardiopulmonary Bypass","Cardiac Surgery","RECRUITING","2025-12-18",{"date":35,"type":36},"2025-12-22","ACTUAL",{"date":38,"type":36},"2025-05-06",{"date":40,"type":20},"2026-02",{"name":42,"class":43},"University of Maryland St. Joseph Medical Center","OTHER",""]