[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"xlh\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:xlh":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":4,"eligibilityCriteria":13,"healthyVolunteers":10,"sex":14,"minAge":15,"maxAge":4,"enrollmentInfo":16,"targetDuration":4,"studyType":19,"phases":20,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100344931",false,"NCT03771105","The Impact of Phosphate Metabolism on Healthy Aging","Inclusion Criteria:\n\n* Children above the age of 13 years\n* Younger and older adults with XLH and HHRH with confirmed NPT2c mutations affecting both copies of the NPT2c gene (HHRH) or one copy of the PHEX gene (XLH)\n* Be willing to provide access to prior medical records to determine eligibility including imaging, biochemical, medical, and surgical history data\n* Be willing and able to complete all aspects of the study\n* Be willing to adhere to the study visit schedule and comply with the assessments (in the opinion of the investigator).\n\nExclusion Criteria:\n\n* Subjects will be excluded, if they are children younger than age 13 years\n* Subjects that have other diseases likely to impact bone and mineral metabolism (e.g. renal, hepatic, gastrointestinal disorders, and malignancy),\n* Subjects that are currently pregnant,\n* Subjects that received medical therapy or developed any condition, which in the opinion of the investigator, could present a concern for either subject safety or difficulty with data interpretation.\n* Subjects will be excluded from Aim 2, if they are unable to tolerate supplemental phosphate.","ALL","13 Years",{"count":17,"type":18},30,"ESTIMATED","INTERVENTIONAL",[21],"EARLY_PHASE1","Determine the association between duration and dose of chronic conventional therapy with Pi and renal (nephrocalcinosis\u002Fnephrolithiasis), vascular (endothelial function), and cardiovascular function (echo- cardiography) in patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH) and patients with X-linked hypophosphatemia (XLH).",[24,25,26,27,28],"Hypophosphatemia","Rickets","Hypercalciuria","XLH","HHRH","RECRUITING","2026-05-21",{"date":32,"type":33},"2026-05-27","ACTUAL",{"date":35,"type":33},"2019-01-01",{"date":37,"type":18},"2028-04",{"name":39,"class":40},"Yale University","OTHER",""]