Health Trials

Clinical trials

2

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Condition / disease
Location
Status: Recruiting

A Phase I, First in Human Study of CBA-1205, Anti-DLK1 Monoclonal Antibody in Patients With Advanced Solid Tumors, Hepatocellular Carcinoma (HCC), Melanoma, and Pediatric Cancer

In this first-in-human, muticenter, non-randomized, open-label, standard 3+3 dose escalation Phase I study encompasses 5 parts (Part 1-5). The purpose of this FIH study is to evaluate the safety and tolerability profile of CBA-1205.

Participants needed: 66
Trial details
Phase: Phase 1Age: 2+Biological sex: AllType: InterventionalSponsor: Chiome Bioscience Inc.Updated: Jun 17, 2026Locations: 5
Eligibility criteria

Patients who provide voluntary written informed consent to participate in the st... [+11]

Patients who have undergone major surgery within 28 days before enrollment [+6]

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Status: Recruiting

A Phase I, First in Human Study of CBA-1535, T Cell Engager(5T4/CD3/5T4) in Patients With Advanced Solid Tumors.

This is a First in Human muticenter, non-randomized, open-label Phase I dose-escalation study of CBA-1535. The study will have 2 parts (Part 1 and Part 2). Part 1 is the dose-escalation cohorts of CBA-1535 single agent theapy. Part 2 is the dose-escalation cohorts of CBA-1535 in combination with Pembrlizumab. This study will evaluate the safety, tolerability, PK, biomarker profiles and preliminary efficacy of CBA-1535.

Participants needed: 70
Trial details
Phase: Phase 1Age: 20+Biological sex: AllType: InterventionalSponsor: Chiome Bioscience Inc.Updated: Jun 12, 2025Locations: 2
Eligibility criteria

Patients who provide voluntary written informed consent to participate in the st... [+3]

Patients who received other investigational drug or antibody drugs, including im... [+2]

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