Clinical trials

14

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

The purpose of this study is to evaluate the safety and efficacy of lisocabtagene maraleucel (Breyanzi/liso-cel/BMS-986387) in adults as first-line treatment in transplant-ineligible Primary Central Nervous System Lymphoma (PCNSL).

Participants needed: 65
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Jul 2, 2026Locations: 40
Eligibility criteria

Participant must be 18 years or older at the time of signing the informed consen... [+7]

Participant has a diagnosis of secondary CNS lymphoma due to systemic disease. [+9]

Status: Recruiting

A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

The purpose of this study is to evaluate the safety, tolerability, efficacy, and drug levels of CC-97540 in participants with Relapsing Forms of Multiple Sclerosis (RMS), Progressive Forms of Multiple Sclerosis (PMS) or Refractory Myasthenia Gravis (MG).

Participants needed: 120
Trial details
Phase: Phase 1Age: 18-60Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Jul 1, 2026Locations: 35
Eligibility criteria

Cohorts 1 and 2: Participants that cannot complete the 9-Hole Peg Test (9-HPT) i... [+3]

Status: Recruiting

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma.

Participants needed: 440
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Jun 26, 2026Locations: 140
Eligibility criteria

Participants must have relapsed or refractory multiple myeloma (RRMM). [+5]

Participants must not have known active or history of central nervous system (CN... [+3]

Status: Recruiting

A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

The purpose of this study is to evaluate the efficacy, safety and drug levels of CC-97540 in participants with active systemic lupus erythematosus (SLE) including lupus nephritis with inadequate response to glucocorticoids and at least 2 immunosuppressants.

Participants needed: 89
Trial details
Phase: Phase 2Age: 16+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Jun 24, 2026Locations: 96
Eligibility criteria

Participants must meet EULAR/ACR 2019 criteria for SLE. [+2]

Participants must not have other diseases, conditions, or treatments that may co... [+6]

Status: Recruiting

A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis

The purpose of this study is to compare the efficacy and safety of BMS-986353 versus standard of care in participants with active Systemic Sclerosis

Participants needed: 92
Trial details
Phase: Phase 3Age: 16+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Jun 15, 2026Locations: 56
Eligibility criteria

Participants must not have a requirement for supplemental oxygen therapy and/or... [+5]

Status: Recruiting

A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refractory autoimmune diseases (Breakfree-1).

Participants needed: 270
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Jun 3, 2026Locations: 54
Eligibility criteria

Diagnosis of Idiopathic Inflammatory Myopathy (IIM) defined as follows:. [+2]

SLE overlap syndromes including, but not limited to, rheumatoid arthritis, scler... [+2]

Status: Recruiting

A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases

The purpose of this study is to determine the safety, tolerability, optimal dose, and preliminary efficacy of BMS-986515, a healthy donor (HD) allogeneic CD19-targeted CART cell product, in participants with severe, refractory autoimmune diseases.

Participants needed: 125
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: May 27, 2026Locations: 28
Eligibility criteria

SLE population:. [+4]

Status: Recruiting

Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

The purpose of this study is to evaluate the effectiveness and safety of Arlocabtagene Autoleucel (BMS-986393) in participants with relapsed or refractory multiple myeloma.

Participants needed: 230
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: May 28, 2026Locations: 52
Eligibility criteria

Documented diagnosis of multiple myeloma (MM) as per International Myeloma Worki... [+4]

Active or history of central nervous system involvement with MM. [+3]

Status: Not yet recruiting

Study of Zola-cel (BMS-986353), in Participants With Autoimmune Cytopenia (Breakfree-AiCE)

The purpose of this study is to evaluate the safety and efficacy of Zola-cel (BMS-986353), in participants with chronic immune thrombocytopenia (cITP) and autoimmune hemolytic anemia (AIHA).

Participants needed: 52
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: May 22, 2026Locations: 8
Eligibility criteria

Documented clinical diagnosis of chronic ITP (cITP) without other clinical manif... [+4]

ITP or AIHA associated with: Evans syndrome, other systemic autoimmune disease o... [+3]

Status: Recruiting

A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

The purpose of this study is to assess BMS-986453 in participants with relapsed and/or refractory multiple myeloma (RRMM).

Participants needed: 187
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Mar 18, 2026Locations: 19
Eligibility criteria

Participants must have a diagnosis of multiple myeloma with relapsed and/or refr... [+4]

Participants must not have any known active or history of central nervous system... [+3]

Status: Recruiting

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

The purpose of this study is to establish a safe and tolerable dose of arlocabtagene autoleucel (BMS-986393) in combinations with alnuctamab, mezigdomide, iberdomide, and elranatamab in participants with relapsed and/or refractory multiple myeloma (RRMM).

Participants needed: 147
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Feb 18, 2026Locations: 19
Eligibility criteria

History of relapsed and/or refractory multiple myeloma (RRMM) treated with at le... [+2]

Prior treatment with alnuctamab (Arm A), mezigdomide (Arm B), iberdomide (Arm C)... [+2]

Status: Recruiting

A Study of Patients With Relapsed/Refractory Mantle Cell Lymphoma Treated With Lisocabtagene Maraleucel in the Post-Marketing Setting

The purpose of this study is to understand the long-term safety and effectiveness of lisocabtagene maraleucel (liso-cel) for the treatment of Mantle Cell Lymphoma (MCL).

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Feb 24, 2025Locations: 1
Eligibility criteria

Participants known to be participating in investigational studies at the time of... [+1]

Status: Recruiting

A Study of Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Treated With Lisocabtagene Maraleucel in the Post-Marketing Setting

The purpose of this study is to characterize the long-term safety of lisocabtagene maraleucel (liso-cel), focusing on patients treated in the chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) indication, and will be part of post-marketing liso-cel pharmacovigilance activities

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Feb 24, 2025Locations: 1
Eligibility criteria

Participants known to be participating in investigational studies at the time of... [+1]

Status: Recruiting

A Study to Patients With Relapsed/Refractory Follicular Lymphoma Treated With Liso-cel (Lisocabtagene Maraleucel) in the Post Marketing Setting

The purpose of this study is to characterise the long-term safety of lisocabtagene maraleucel, focusing on patients treated in the approved follicular lymphoma (FL) indication, and will be part of post-marketing liso-cel pharmacovigilance activities

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyUpdated: Feb 24, 2025Locations: 1
Eligibility criteria

Participants known to be participating in investigational studies at the time of... [+2]