Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans
ConditionHealthy Adults
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age23-90
SponsorMinicircle
About this trial
The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.
Eligibility criteria
Qualifiers
Participant is open to morphological change
If female, participant agrees to maintain contraception
If female, participant agrees to take a pregnancy test
If female, participant agrees to a pregnancy waiver
Disqualifiers
Women of childbearing potential who are unwilling or unable to use effective contraception for the duration of the study
History of cancer diagnosis
Preexisting medical issues that may be exacerbated by the treatment
Has received any gene therapy within the past 12 months
Trial design
Treatments tested in this trial
- Injectable Plasmid Klotho Gene Therapy
Treatment groups
24 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov