Health Trials

Canadian Critical Care Comparative Effectiveness Platform

ConditionsIntensive Care Unit ICUVasopressorPlateletNutrition
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversité de Sherbrooke

About this trial

The Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC) is an international multi-centered randomized adaptive platform clinical trial. CEPEC will evaluate supportive care interventions that are used routinely in intensive care units throughout the world.

Eligibility criteria

Qualifiers

Ongoing vasopressor infusion to treat hypotension, or would be used to treat clinician-defined hypotension as part of usual care;

MAP <75 mmHg at any point;

Patient expected to be in the ICU for >24 hours.

Disqualifiers

Treating team does not have equipoise for at least two contiguous MAP target ranges in the CEPEC Vasopressor Domain;

Acute traumatic brain injury (within 7 days or ongoing active treatment for elevated intracranial pressure);

Acute subarachnoid hemorrhage (within 21 days);

Acute spinal cord injury (within 7 days of injury or ongoing vasopressor therapy for suspected spinal cord ischemia);

Trial design

Treatments tested in this trial

  • 1- Vasopressor - Mean arterial pressure 56-60
  • 2- Vasopressor - Mean arterial pressure 61-65
  • 3- Vasopressor - Mean arterial pressure 66-70
  • 4- Vasopressor - Mean arterial pressure 71-75
  • 1- Platelet less than 10 x 109/L
  • 2- Platelet less than 20 x 109/L
  • 3- Platelet less than 30 x 109/L
  • 4- Platelet less than 40 x 109/L
  • 5- Platelet less than 50 x 109/L
  • Enteral nutrition - Boluses
  • Enteral nutrition - Continuous

Treatment groups

5,500 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Université de Sherbrooke

Lead sponsor

Hamilton Health Sciences Corporation

Collaborator

Source ClinicalTrials.gov